A5003749444- Retinoids in leukemia and cellular processes
- Arsenic contamination and mitigation
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Thermal Expansion and Ionic Conductivity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Acne and Rosacea Treatments and Effects
- DNA Repair Mechanisms
- Catalytic Alkyne Reactions
- Fluorine in Organic Chemistry
- Synthesis and properties of polymers
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Silicone and Siloxane Chemistry
- Epoxy Resin Curing Processes
- Acute Lymphoblastic Leukemia research
- Advanced Battery Technologies Research
- Conducting polymers and applications
- Supercapacitor Materials and Fabrication
- Genetically Modified Organisms Research
- Hematopoietic Stem Cell Transplantation
- 3D Printing in Biomedical Research
Northeast Normal University
2023-2025
Xiangtan University
2023-2024
Chinese Academy of Agricultural Sciences
2021-2023
Ministry of Agriculture and Rural Affairs
2021-2023
Institute of Food Science and Technology
2021-2023
Guangdong Ocean University
2023
Harbin Medical University
2021-2022
First Affiliated Hospital of Harbin Medical University
2021-2022
Central South University
2021-2022
Shanghai Jiao Tong University
2022
Abstract The skeletal ring expansion of heteroarenes through carbene insertion is gaining popularity in synthetic chemistry. Efficient strategies for heterocyclic to access heterocycles containing a fluoroalkyl quaternary carbon center are highly desirable because their broad applications medicinal Herein, we report general strategy the dearomative one‐carbon azoles using N ‐triftosylhydrazones as precursors, resulting ring‐expanded excellent yields with good functional‐group compatibility....
Abstract Given the prevalence of heterocyclic scaffolds in drug‐related molecules, converting these highly modular into structural diversified and dearomatized analogs is an ideal strategy for improving their physicochemical pharmacokinetic properties. Here, we described efficient method silver carbene‐mediated dearomative N−N bond cleavage leading to skeletal hopping between indazole 1,2‐dihydroquinazoline via a selective single‐carbon insertion procedure. Using this methodology, series...
Herein, we developed the new, powerful, and easy-to-handle chemical reagent, dimethoxyacetaldehyde-N-triftosylhydrazone (DMHz-Tfs), as a convenient in situ source of dimethoxydiazoethane under mild conditions. We demonstrate carbene reactivity DMHz-Tfs iron-catalyzed cyclopropanation Doyle-Kirmse reactions, providing access to diverse acetal functionalized cyclopropanes homoallylic- allenyl-sulfides at gram-scale with high stereoselectivity. DFT calculations elucidated involvement most...
Here, we report a silver carbene-enabled single-carbon insertion reaction of indoles via one-pot, two-step sequence to deliver dearomative quaternary center quinoline scaffold in modular fashion. Specifically, used N-triftosylhydrazones as masked donor–donor carbene precursors that facilitate the carbon atoms bearing various functional groups library functionalized quinoline. Experimental and DFT evidence support transient presence cyclopropane species removal protecting groups.
Soluble polyimides with –OCFCF 2 side groups were successfully prepared from a vanillin-derived aromatic diamine. After crosslinking, fluorinated polyimide networks obtained high thermal resistance, transparency and mechanical strength.
A facile strategy has been developed to produce semi-aromatic polyimides through direct in situ thermo-polymerization. The obtained exhibit favorable performances and are presented as potential candidates applied microelectronics.
Abstract The cardiotoxicity induced by arsenic trioxide (ATO) limits its clinical application in acute promyelocytic leukemia treatment. Sacubitril/valsartan (LCZ696) is an effective drug for the treatment of heart failure. In this study, we aimed to investigate protective effect and mechanisms LCZ696 against ATO-induced mice H9c2 cells. We found that could alleviate decrease ejection fraction fractional shortening ATO, thereby improving mouse cardiac contractile function. also reduce...
Oral arsenic trioxide (ATO) has demonstrated a favorable clinical efficiency in the treatment of acute promyelocytic leukemia (APL). However, pharmacokinetic characteristics, tissue bioaccumulation, and toxicity profiles metabolites vivo following oral administration ATO have not yet been characterized. The present study uses high performance liquid chromatography-hydride generation-atomic fluorescence spectrometry (HPLC-HG-AFS) to assess pharmacokinetics rat plasma after intravenous 1 mg kg...
Arsenic speciation in cerebrospinal fluid (CSF) is critical for treatment/prevention of central nervous system (CNS) relapse acute promyelocytic leukaemia (APL) patients treated with arsenic trioxide (ATO). Previous study showed low total level CSF APL patients. Mannitol infusion was applied to improve blood-brain barrier (BBB) permeability arsenic. Arsenite (AsIII ), monomethylarsonic acid (MMAV dimethylarsinic (DMAV and arsenate (AsV ) plasma were analysed by high performance liquid...
Background: Arsenic trioxide (ATO) is successfully applied to treat acute promyelocytic leukemia (APL). species levels in blood are critical reveal metabolic mechanism and relationship between arsenic clinical response. Characteristics influence factors of APL patients have not been studied.Methods: 305 plasma samples from treated with ATO were analyzed using HPLC-HG-AFS. Trough concentration (Ctrough), distribution, methylation evaluated. The on association concentrations efficacy...
Interstrand crosslinks (ICLs) repair by the canonical Fanconi anemia (FA) pathway generates double-strand breaks (DSBs), which are subsequently repaired homologous recombination (HR) pathway. Recent studies show that NEIL3 DNA glycosylase repairs psoralen-ICLs direct unhooking. However, whether and how regulates MMC cisplatin-ICL remains unclear. Here we participates in DSB step of ICL promoting HR Mechanistically, is recruited to sites through its GRF zinc finger motifs. interacts with...
Background: Arsenic trioxide (ATO) was successfully applied to treat acute promyelocytic leukemia (APL).Methods: Inorganic arsenic (iAs), monomethylarsonic acid (MMAV) and dimethyarsinic (DMAV) in plasma of 143 APL patients with different renal function were determined. methylation capacity evaluated by iAs%, MMAV%, DMAV%, primary index (PMI, MMAV/iAs), secondary methylated (SMI, DMAV/MMAV). accumulation administration frequency explored. Moreover, safety assessments performed.Results:...
Balanced photoinduced electron transfer (PET) and hole (PHT) processes is achieved in ternary OSCs as a result of the improved phase morphology crystallization active layer formation “acceptor alloys”.
Background. Previous studies have shown that ferroptosis plays an integral role in the development of cancer and copy number variations (CNVs) been reported to associated with ferroptosis. However, CNVs-driven ferroptosis-related genes (FRGs) lung adenocarcinoma (LUAD) continues be poorly understood. Therefore, we aimed establish a novel gene signature LUAD based on genes. Methods. The transcriptome data clinical features patients were downloaded from Gene Expression Omnibus (GEO) database...
Abstract The skeletal ring expansion of heteroarenes through carbene insertion is gaining popularity in synthetic chemistry. Efficient strategies for heterocyclic to access heterocycles containing a fluoroalkyl quaternary carbon center are highly desirable because their broad applications medicinal Herein, we report general strategy the dearomative one‐carbon azoles using N ‐triftosylhydrazones as precursors, resulting ring‐expanded excellent yields with good functional‐group compatibility....