A5101571685- Catalytic C–H Functionalization Methods
- Dementia and Cognitive Impairment Research
- Cyclopropane Reaction Mechanisms
- Alzheimer's disease research and treatments
- Catalytic Cross-Coupling Reactions
- Catalytic Alkyne Reactions
- Intracranial Aneurysms: Treatment and Complications
- Fluorine in Organic Chemistry
- Spinal Fractures and Fixation Techniques
- Sulfur-Based Synthesis Techniques
- Pelvic and Acetabular Injuries
- Parkinson's Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Optimization and Variational Analysis
- Oxidative Organic Chemistry Reactions
- Cyclization and Aryne Chemistry
- Ginkgo biloba and Cashew Applications
- Folate and B Vitamins Research
- Scoliosis diagnosis and treatment
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Blood disorders and treatments
- Esophageal and GI Pathology
Northeast Normal University
2023-2025
Tianjin Medical University
2015-2023
Tianjin Huanhu Hospital
2015-2023
Chengdu Medical College
2018
PLA 306 Hospital
2015
UNSW Sydney
2015
Anhui Agricultural University
2012-2013
Second Hospital of Shandong University
2008-2013
Huaibei Normal University
2012-2013
Shanghai Institute of Organic Chemistry
2011
Total homocysteine (tHcy) levels are associated with secondary vascular events and mortality after stroke. The aim of this study was to investigate whether tHcy in the acute phase a stroke contribute recurrence cerebro-cardiovascular mortality.A total 3799 patients were recruited hospital admission for ischemic Levels measured within 24 hours primary admission. Patients followed median 48 months.During follow-up period, 233 (6.1%) died. After adjustment age, smoking status, diabetes...
Abstract The skeletal ring expansion of heteroarenes through carbene insertion is gaining popularity in synthetic chemistry. Efficient strategies for heterocyclic to access heterocycles containing a fluoroalkyl quaternary carbon center are highly desirable because their broad applications medicinal Herein, we report general strategy the dearomative one‐carbon azoles using N ‐triftosylhydrazones as precursors, resulting ring‐expanded excellent yields with good functional‐group compatibility....
Comprehensive Summary The [2+1] cycloaddition of alkynes with fluoroalkyl carbenes represents the most straightforward approach for constructing fluoroalkylated cyclopropenes. However, until now, this strategy has not been applicable to difluoromethyl carbene, as its precursor, diazomethane, tends undergo [3+2] form pyrazoles. This study presents first example copper‐catalyzed cyclopropenation employing difluoroacetaldehyde triftosylhydrazone carbene precursor. A wide range internal and...
An intramolecular cyclization of 2-(gem-dibromovinyl)phenols(thiophenols) to give 2-bromobenzofurans(thiophenes) in the presence a trace amount Cu (0.0064 mol%, 25 ppm) has been developed. The reaction provides desired products excellent yields under fluoride-free and mild conditions with TON (turnover number) up 1.5 × 104.
Abstract 2‐Arylbenzofurans(thiophenes) were prepared through an efficient tandem elimination–intramolecular addition–Hiyama cross‐coupling reaction. In the presence of tetra‐( n ‐butyl)ammonium fluoride (TBAF), palladium(II) acetate [Pd(OAc) 2 ] and triphenylphosphine (PPh 3 ), reaction 2‐( gem ‐dibromovinyl)phenols(thiophenols) with phenyl(trialkoxy)silanes proceeded smoothly generated corresponding products good yields in one‐pot. It should be noted that TBAF plays important role
The aim of this study was to investigate the dynamic changes in coagulation and fibrinolytic system with subarachnoid hemorrhage. blood enzyme-AT complex (TAT), anticoagulant enzyme (AT), tissue plasminogen activator (tPA), activin inhibitor (PAI-1), mean flow velocity were measured. TAT level significantly higher 6 h after hemorrhage (SAH), whereas AT lower. These maintained at 12 1 d SAH, returned normal 3 d, changed again 7 14 d. tPA gradually increased SAH peaked then 21 PAI-1 levels...
Primary headache disorders are among the most common neurological complaints worldwide, and significant causes of disability. Data limited on prevalence primary headaches individuals aged 60 years older in China. The purpose our study was to investigate characteristics people a rural area northern A door-to-door survey conducted Ji County Tianjin Province. total 5248 residents were visited from 2014 2015, unannounced, basic sociodemographic diagnostic information collected via questionnaire....
Abstract Introduction Rapid cognitive decline (RCD) occurs in dementia due to Alzheimer's disease (AD). Methods Literature review, consensus meetings, and a retrospective chart review of patients with probable AD were conducted. Results showed that RCD definitions varied. Mini‐Mental State Examination scores <20 at treatment onset, vascular risk factors, age <70 years symptom higher education levels, early appearance hallucinations, psychosis, or extrapyramidal symptoms are recognized...
Posterior cortical atrophy (PCA) is a clinicoradiologic neurodegenerative syndrome characterized by predominant impairment of higher visual functions. Neuroimaging and neuropathological studies show that PCA probably an atypical presentation Alzheimer’s disease. However, in China has rarely been studied remains largely unknown. Our study therefore aimed to analyze the clinical manifestations patterns cerebral atrophy, amyloid beta deposition regional glucose metabolism Chinese patients,...
2-Bromoindoles were readily prepared through a facile Cs2CO3-promoted intramolecular cyclization of 2-(gem-bromovinyl)-N-methylsulfonylanilines in excellent yields under transition-metal-free conditions. This methodology could be extended to the synthesis corresponding 2-chloroindoles. The reaction mechanism suggested that occurs key intermediate, phenylethynyl bromide, followed by one-pot.
Dementia with Lewy bodies (DLB) is the second most common subtype of degenerative dementia. To our knowledge, available information about clinical features DLB in China remains limited. Our study therefore aimed to address this issue. Thirty-seven Chinese patients probable were recruited for study. All subjects underwent neuropsychological assessment by trained neurologists, as well undergoing MRI, 11C-PIB PET scans Aβ deposition and 18F-FDG regional cerebral glucose metabolism. results...
Objective This study explored the clinical features of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) analyzed differences in neurologic syndromes, including mirror TV signs, between different groups. Methods Patients AD DLB (325 115, respectively) hospitalized our institution were enrolled. We compared psychiatric symptoms syndromes groups within each subgroup, mild-moderate severe subgroups. Results The prevalence rates visual hallucination, parkinsonism, rapid eye movement...
A silver-catalyzed regioselective defluorinative 1,3-dienylation of trifluoromethyl phenyl N-triftosylhydrazones using homoallenols as 1,3-dienyl sources provides a variety α-(di)fluoro-β-vinyl allyl ketones with excellent functional group tolerance in moderate to good yields. The reaction proceeds through silver carbene-initiated sequential etherification and Claisen type [3,3]-sigmatropic rearrangement cascade. synthetic utility this protocol was demonstrated the downstream elaboration...
A highly active, air- and moisture-stable easily recoverable magnetic-nanoparticle-supported palladium catalyst has been developed for the Suzuki cross-coupling reaction of organoboron derivatives with alkynyl bromides. In presence (0.5 mol%), including aromatic aliphatic boronic acids, potassium aryltrifluoroborates, sodium tetraphenylborate reacted smoothly 1-bromo-2-substituted acetylenes to generate corresponding products in good excellent yields ethanol. addition, it is possible recover...
Autonomic dysfunction is supportive clinical feature for diagnosis of prodromal dementia with Lewy bodies (DLB).To compare the features autonomic symptoms in patients mild cognitive impairment (MCI) due to (MCI-LB) and Alzheimer's disease (MCI-AD).Autonomic were evaluated MCI-LB MCI-AD using Scales Outcomes Parkinson's (SCOPA-AUT).Thirty 90 recruited. The frequency was higher compared (80% versus 54.4%, p = 0.013) gastrointestinal predominant (73.3% 35.6%, < 0.001). Salivation,...
Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is a common type of autoimmune characterized by complex clinical signs and variable imaging manifestations. The pathogenesis the disease unclear. Syphilis an infectious caused Treponema pallidum that can invade nervous immune systems cause systemic symptoms. There are few reports anti-NMDAR with syphilis, association between them unknown; both diseases related to system damage. We report case syphilis.A 32-year-old man was admitted our...
Saturated sets and its reduced case the set of generic points are two types important fractal-like in Multifractal analysis dynamical systems. In context infinite entropy systems, this paper aims to give some qualitative aspects saturated both topological measure-theoretic situations. For systems with specification property, we establish certain variational principles for terms Bowen packing metric mean dimensions, show upper capacity dimension have full dimension. All results useful...
Motivation: The choroid plexus has been demonstrated to play a significant role in the pathophysiology of dementia with Lewy bodies (DLB), however imaging characteristics are not yet explored. Goal(s): Our goal was assess area and permeability based on MRI DLB patients. Approach: patients were imaged acquire compared Alzheimer&rsquo;s disease healthy controls. Results: exhibited larger lower fractional plasma volume than Additionally, they found be significantly associated mini-mental...