A5087295137- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Catalytic Alkyne Reactions
- Mycobacterium research and diagnosis
- Organometallic Complex Synthesis and Catalysis
- Tuberculosis Research and Epidemiology
- Fluorine in Organic Chemistry
- Coordination Chemistry and Organometallics
- Carbohydrate Chemistry and Synthesis
- Ferrocene Chemistry and Applications
- Catalytic Cross-Coupling Reactions
- Chemical Reactions and Mechanisms
- Lignin and Wood Chemistry
- Biochemical and Molecular Research
- Synthesis and Reactivity of Heterocycles
- Biofuel production and bioconversion
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Inorganic and Organometallic Chemistry
- Organic Chemistry Cycloaddition Reactions
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Molecular spectroscopy and chirality
- Cancer Treatment and Pharmacology
Bangor University
2015-2025
Oak Ridge National Laboratory
2021-2023
Natural Resources Wales
2022-2023
National Technical Information Service
2021-2022
Office of Scientific and Technical Information
2021-2022
Oral Roberts University
2020
New York University
2017
University of Southampton
2017
American Neurogastroenterology and Motility Society
2012
University of Wales
2004-2009
Original lignin and hemicelluloses were sequentially extracted with high yield/purity, using acidic dioxane/water solution dimethyl sulfoxide, from ball-milled wheat straw. The dioxane fraction is distinguished by β-O-4' structures low amounts of condensed units (β-5', 5-5', β-1'). Hemicelluloses contain arabinoxylans as the major polysaccharides, which are substituted α-l-arabinofuranose, 4-O-methylglucuronic acid, acetyl group (DS = 0.1), xylose at O-3 and/or O-2 xylans. It was found that...
Abstract: The variety of biological systems which are modulated by naturally occurring cyclopropanes has only been realized recently. They range from antibiotic, antiviral, antifungal and insecticidal activities, control plant growth fruit ripening, antimycotic, thyromimetic, hormonal, carcinogenic or antitumoral enzyme gluconeogenesis inhibitions, to neuro chemical activity. Cyclopropanes also major components membranes, for instance in tuberculosis cells, key intermediates many...
Sequential treatments of dewaxed bagasse with distilled water, 0.5 M NaOH, 0.5, 1.0, 1.5, 2.0, and 3.0% H(2)O(2) at pH 11.5, 2 NaOH 55 degrees C for h solubilized 2.8, 52.5, 14.9, 3.3, 5.5, 5.0, 2.2% the original lignin, respectively. The eight isolated lignin fractions were subjected to a comprehensive structural characterization by UV, FT-IR, (1)H (13)C NMR spectroscopies thermal analysis. nitrobenzene oxidation method was also applied in situ lignins. seven fractions, successively alkali...
The thiourea isoxyl (thiocarlide; 4,4′-diisoamyloxydiphenylthiourea) is known to be an effective anti-tuberculosis drug, active against a range of multidrug-resistant strains Mycobacterium tuberculosis and has been used clinically. Little was its mode action. We now demonstrate that results in dose-dependent decrease the synthesis oleic and, consequently, tuberculostearic acid M. with complete inhibition at 3 μg/ml. Synthesis mycolic also affected. anti-bacterial effect partially reversed by...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclopropanone reactions. Cyclobutanone derivatives from vinylic and acetylenic cyclopropanolsHarry H. Wasserman, Robert E. Cochoy, Mark S. BairdCite this: J. Am. Chem. Soc. 1969, 91, 9, 2375–2376Publication Date (Print):April 1, 1969Publication History Published online1 May 2002Published inissue 1 April 1969https://doi.org/10.1021/ja01037a034Request reuse permissionsArticle Views748Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are...
ABSTRACT The genes from the oxygenase cluster nagAaGHAbAcAd of naphthalene-degrading Ralstonia sp. strain U2 were cloned and overexpressed. Salicylate 5-hydroxylase (S5H) activity, converting salicylate to gentisate, was present in vitro only single extract cells with overexpressed nagAaGHAb or a mixture three cell extracts containing, respectively, NagGH (the components), NagAa (ferredoxin reductase), NagAb (ferredoxin). Each required for S5H activity rate limiting presence excess others...
Mycolic acids (MAs) occur in the cell wall of Mycobacterium tuberculosis as variable mixtures different classes and chain lengths. Here, we address relationship between structure its inflammatory function this virulence factor using single synthetic MA isomers, differing oxygenation class cis- versus α-methyl-trans proximal cyclopropane orientation. Analysis bronchoalveolar inflammation, lung histopathology alveolar macrophage transcription revealed a strong dependence on these meromycolic...
Significance Tuberculosis is a major global pandemic responsible for more deaths than any other infectious disease, yet no effective vaccine exists. Here, we demonstrate CD1b expression within human tuberculous granulomas, supporting role lipid antigen presentation in host immunity to infection. presents mycolates, the dominant Mycobacterium tuberculosis (Mtb) cell wall class and key virulence factors, αβ T cells. We reveal that mycolate tail moieties, distal head group, are antigenic...
Reaction of a range 1,1,2-trihalogenocyclopropanes (halogen = bromine, chlorine) with methyl-lithium in ether at –90–20 °C leads to 1,2-dehalogenation the corresponding 1-halogenocyclopropene. The halogenocyclopropenes are readily lithiated by lithium–halogen exchange second equivalent give 1-lithiocyclopropenes, which turn trapped electrophiles; an exception this is compound (21; X Cl), 3-methylbuta-1,2-dienylidene (31) initial lithium–hydrogen and loss lithium chloride. cyclopropenes (5; R...
Diazocyclopentadiene (1) was photolyzed in N(2), CO, and other low-temperature matrices. The resulting carbene, cyclopentadienylidene (2), characterized by its UV IR spectra, thermal dimerization reaction with CO were observed. Photolysis of 1 plane-polarized light gave matrices exhibiting linear dichroism. Comparison dichroic spectra revealed that the photolysis proceeds via an excited A(l) state diazo compound. Plane-polarized irradiation corresponding ketene (4) resulted...
Significance T cells autoreactive to cluster of differentiation 1c (CD1c) are abundant in human blood but lipid antigens recognized by these remained poorly understood. A new 2.4-Å structure CD1c and computational simulations thereof indicated substantial conformational plasticity with ligand-induced formation an F′ roof G′ portal, as well the potential present acylated sterols. Confirming predictions we demonstrated loading biophysical interaction CD1c–lipid complexes self-reactive T-cell...
The problem: Ante-mortem diagnosis of Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is normally achieved through faecal culture, PCR, or serological tests, but agreement as to which samples are positive for disease often poor and sensitivities low, particularly in early-stage infections. potential solution: Mycobacterial cells contain very complex characteristic mixtures mycolic acid derivatives that elicit antibodies during infection; this has been used...