A5023783093- Radioactive element chemistry and processing
- Photosynthetic Processes and Mechanisms
- Lanthanide and Transition Metal Complexes
- Immune Cell Function and Interaction
- Marine and coastal ecosystems
- Monoclonal and Polyclonal Antibodies Research
- Microbial Community Ecology and Physiology
- T-cell and B-cell Immunology
- Brucella: diagnosis, epidemiology, treatment
- Chemical Synthesis and Characterization
- Metal complexes synthesis and properties
- Reproductive tract infections research
- Bipolar Disorder and Treatment
- Bacterial Infections and Vaccines
- Immune Response and Inflammation
- Metalloenzymes and iron-sulfur proteins
- Methane Hydrates and Related Phenomena
- Adenosine and Purinergic Signaling
- Microbial Fuel Cells and Bioremediation
- Iron oxide chemistry and applications
National Oceanography Centre
2018-2024
University of Southampton
2016-2024
The marine cyanobacterium Prochlorococcus is a main contributor to global photosynthesis, whilst being limited by iron availability. Cyanobacterial genomes generally encode two different types of FutA iron-binding proteins: periplasmic FutA2 ABC transporter subunits bind Fe(III), while cytosolic FutA1 binds Fe(II). Owing their small size and economized genome ecotypes typically possess single futA gene. How the encoded protein might Fe oxidation states was previously unknown. Here, we use...
Significance T cells autoreactive to cluster of differentiation 1c (CD1c) are abundant in human blood but lipid antigens recognized by these remained poorly understood. A new 2.4-Å structure CD1c and computational simulations thereof indicated substantial conformational plasticity with ligand-induced formation an F′ roof G′ portal, as well the potential present acylated sterols. Confirming predictions we demonstrated loading biophysical interaction CD1c–lipid complexes self-reactive T-cell...
Neisseria gonorrhoeae (gonococcus [Ng]) is the causative organism of sexually transmitted disease gonorrhoea, and no effective vaccine exists currently. In this study, structure, biological properties, potential Ng-adhesin complex protein (Ng-ACP) are presented. The crystal structure recombinant Ng-ACP (rNg-ACP) was solved at 1.65 Å. Diversity conservation were examined in different species gonococcal isolates (https://pubmlst.org/neisseria/ database) silico, expression among 50 strains...
Atmospheric nitrogen fixation by photosynthetic cyanobacteria (diazotrophs) strongly influences oceanic primary production and in turn affects global biogeochemical cycles. Species of the genus Trichodesmium are major contributors to marine diazotrophy, accounting for a significant proportion fixed tropical subtropical oceans. However, spp. metabolically constrained availability iron, an essential element both apparatus nitrogenase enzyme. Survival strategies low-iron environments typically...
Presentation of lipid antigens to T cells is negotiated by CD1 proteins (Cluster differentiation 1).CD1 are a family MHC class I-like glycoproteins, distinguished into five different classes that differ in substrate specificity and intracellular trafficking.Determining their individual unique features instrumental understanding roles host defense immune regulation.We have studied the CD1c isoform determined 2.4 Å structure presence ligands, differentiating this from other CD1proteins.The...
Abstract The marine cyanobacterium Prochlorococcus is a main contributor to global photosynthesis, whilst being limited by iron availability. Cyanobacterial genomes typically encode two different types of FutA binding proteins: periplasmic FutA2 ABC transporter subunits bind Fe(III), while cytosolic FutA1 binds Fe(II). Owing their small size and economized genome ecotypes possess single futA gene. How the encoded protein might Fe oxidation states was previously unknown. Here we use...