A5100450126- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Knowledge Management and Technology
- Spectroscopy and Chemometric Analyses
- RNA regulation and disease
- Regulation of Appetite and Obesity
- Electrochemical sensors and biosensors
- Alcohol Consumption and Health Effects
- Pediatric health and respiratory diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Oral microbiology and periodontitis research
- Anesthesia and Neurotoxicity Research
- Intracranial Aneurysms: Treatment and Complications
- Quality and Safety in Healthcare
- Spectroscopy Techniques in Biomedical and Chemical Research
- Physiological and biochemical adaptations
- Pancreatic and Hepatic Oncology Research
- Cerebrovascular and Carotid Artery Diseases
- Cancer, Hypoxia, and Metabolism
- Dental Health and Care Utilization
- Folate and B Vitamins Research
Southern Medical University
2018-2025
Nanfang Hospital
2025
Guangxi University of Science and Technology
2023
Hubei University of Medicine
2017-2022
Taihe Hospital
2010-2021
Second Affiliated Hospital of Nanjing Medical University
2020
Zhujiang Hospital
2018
Abstract Parkinson's disease (PD) is neurodegenerative dyskinesia characterized by loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Although neuroinflammation one pathological features PD, its mechanism promoting PD still not fully understood. Recently, microRNA (miR) considered to play a critical regulatory role inflammatory responses. In this study, we examined anti‐inflammatory activity, antineuronal injury, and underlying target miR‐190 with MPTP‐induced mouse...
Previous studies have reported that low-intensity pulsed ultrasound (LIPUS) can alleviate cartilage degradation in osteoarthritis (OA). However, the functions and mechanisms of LIPUS synovial fibrosis with OA require further study. To investigate role PI3K/AKT signaling pathway treatment fibrosis, a TGF-β stimulated rat FLS cell model animal based on anterior cruciate ligament transection (ACLT) partial medial meniscectomy (MMx) were used. The results revealed delayed progression OA. Masson...
Radioresistance is a major challenge during the treatment of NK/T cell lymphoma. This study aimed to investigate potential role MicroRNA-150 (miR-150) in increase sensitivities lymphoma ionizing radiation. In this study, we found that miR-150 was significantly decreased tissues and lines. Low expression positively associated with therapeutic resistance 36 cases. Our further vitro vivo studies illustrated overexpression substantially enhanced sensitivity cells radiation treatment....
Objective: Both tooth loss and dementia are age-related frequently-occurring diseases. Increasing attention has been given to explore the pathogenesis related oral-brain function disorders. The present study was performed evaluate association between through a dose-response meta-analysis. Methods: Relevant cohort studies were searched from online databases up until June 20, 2018, which examined risk of dementia. Literature selection according inclusion exclusion criteria, as well data...
Hypoxic-ischemic brain damage (HIBD) is a relatively common malignant complication that occurs in newborn infants, but promising therapies remain limited. In this study, we focused on the role of miR-326 and its target gene δ-opioid receptor (DOR) pathogenesis neonatal HIBD. The expression levels DOR after hypoxic-ischemic injury were examined both vivo vitro. direct relationship between was confirmed by dual-luciferase reporter assay. Further, effects cell viability apoptosis under oxygen...
Chinese giant salamander (Andrias davidianus) undergoes a metamorphosis from aquatic larvae to terrestrial adults, with concomitant transfer of respiration gills lungs prior metamorphosis. These two tissues, as well skin, were sampled identify the differentially expressed miRNAs. High-coverage reference transcriptome was generated combined gill, lung and skin tissues metamorphosing juveniles, tissue adults: 86,282 unigenes total length approximately 77,275,634 bp N50 1732 obtained. Among...
Background and Aim Cerebral vasospasm (CVS) is one of the main causes adverse outcomes due to delayed ischemic cerebral infarction in patients with subarachnoid hemorrhage (SAH). The purpose this study was explore CVS-related risk factors elderly SAH, providing a basis for early clinical prediction therapeutic strategy. Methods Data including demographic factors, healthy habits, history, stress complications Hunt-Hess grade acute phase, treatment time, bleeding-involved encephalic region...
Background: To observe and explore the clinical effect of motor imagery therapy (MIT) combined with low-frequency pulsed electrical stimulation (LFPEST) on improving upper limb function in young stroke patients. Methods: Eighty-one patients hemiplegia were divided into MIT group, LFPEST group treatment group. Fugl-Meyer assessment (FMA), functional test hemiplegic extremity (FTHUE) modified Barthel Index (MBI) used to evaluate activities daily living before 6 weeks after treatment. Results:...
The determination of antiepileptic drugs and antipsychotics in human serum is great importance the field individualized drug administration therapeutic monitoring (TDM). Here, we developed a rapid label-free TDM method for carbamazepine (CBZ) antipsychotic clozapine (CLO) serum. detection strategy based on combination Surface Enhanced Raman Scattering (SERS) Magnetic Solid Phase Extraction (MSPE). First, synthesized Fe3O4@SiO2@MIL-101(Fe) nanocomposites by layer- by-layer self-assembly...