A5009027186- Veterinary Orthopedics and Neurology
- Neurological diseases and metabolism
- Lysosomal Storage Disorders Research
- Veterinary Oncology Research
- Spinal Dysraphism and Malformations
- Veterinary Medicine and Surgery
- Head and Neck Surgical Oncology
- Spine and Intervertebral Disc Pathology
- Photoreceptor and optogenetics research
- Tumors and Oncological Cases
- Cellular transport and secretion
- Hedgehog Signaling Pathway Studies
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Teratomas and Epidermoid Cysts
- Amyotrophic Lateral Sclerosis Research
- Veterinary Pharmacology and Anesthesia
- Toxoplasma gondii Research Studies
- Glycogen Storage Diseases and Myoclonus
- Veterinary Equine Medical Research
- Cervical and Thoracic Myelopathy
- Advanced MRI Techniques and Applications
- Neurogenetic and Muscular Disorders Research
- 3D Printing in Biomedical Research
- Neurological disorders and treatments
Veterinary Medical Teaching Hospital
2013-2016
University of Missouri
2010-2015
Missouri College
2010-2015
Washington State University
2008-2011
Texas A&M University
2009
University of Pennsylvania
2007-2008
AAV-mediated gene transfer to ependymal cells in a dog model of Batten disease provides sustained enzyme replacement and delays onset.
Using a canine model of classical late‐infantile neuronal ceroid lipofuscinosis (CLN2 disease), study was conducted to evaluate the potential pharmacological activity recombinant human tripeptidyl peptidase‐1 (rhTPP1) enzyme replacement therapy administered directly cerebrospinal fluid (CSF). CLN2 disease is hereditary neurodegenerative disorder resulting from mutations in , which encodes soluble lysosomal (TPP1). Infants with both alleles develop normally but late‐infantile/early‐childhood...
An 8-year-old female spayed Bernese Mountain Dog (BMD) presented to the Bush Veterinary Neurology Service (BVNS) for paraparesis. The dog had been seen at BVNS 13 months earlier evaluation of progressive pelvic limb weakness. At that time, a short-strided gait in limbs, mild postural reaction deficits right limb, normal segmental reflexes, and laxity coxofemoral joint. was treated with meloxicam (0.15 mg/kg PO q24 h) 3 days, amantidine (2 q24h) 1 month, doxycycline (6 q12h) 2 weeks no...
A stereotactic brain biopsy system that is magnetic resonance ( MR ) imaging‐guided has not been validated in dogs. Our purpose was to determine the mean needle placement error caudate nucleus, thalamus, and midbrain of a canine cadaver using modified B rainsight™ system. Relocatable reference markers (fiducial markers) were attached head dental bite block. T 1‐weighted gradient echo three‐dimensional (3 D sequence acquired set parameters. Fiducial used register images 3 position sensor....
Neuronal ceroid lipofuscinosis (NCL), a fatal neurodegenerative disease, has been diagnosed in young adult Australian Cattle Dogs.Characterize the Dog form of NCL and determine its molecular genetic cause.Tissues from 4 Dogs with NCL-like signs buccal swabs both parents fifth affected breed member. Archived DNA samples 712 individual dogs were genotyped.Tissues examined by fluorescence, electron, immunohistochemical microscopy. A whole-genome sequence was generated for 1 dog. TaqMan allelic...
The neuronal ceroid lipofuscinoses (NCLs) are autosomal recessive lysosomal storage diseases characterized by progressive neurodegeneration and accumulation of autofluorescent material in the central nervous system other tissues. One most prominent clinical signs NCL is decline cognitive function. We previously described a frame shift mutation TPP1 miniature long-haired Dachshunds which causes an early-onset form analogous to classical late-infantile onset (CLN2) children. Dogs homozygous...
To evaluate the relationship between Doppler blood pressure (DBP) and survival or response to treatment in critically ill cats.Retrospective case series.83 cats.Medical records from cats admitted intensive care unit with at least 2 recorded DBP measurements were included study. Hypotension was defined as 1 more d 90 mm Hg. Change pressure, hospital discharge, heart rate, rectal temperature, PCV, plasma pH, serum ionized calcium concentration, disease process, body weight, age, duration of...
Abstract Objective —To determine the change in stiffness as evaluated by dorsal bending moment of cervical vertebral specimens obtained from canine cadavers after internally stabilizing motion unit (VMU) C4 and C5 with a traditional pin-polymethylmethacrylate (PMMA) fixation implant or novel screw-bar–PMMA implant. Sample Population —12 column (C3 through C6) cadavers. Procedures —A was applied to before VMU use pin-PMMA Biomechanical data were collected compared within specimen (unaltered...
Direct optical methods to stimulate and record neural activity provide artifact-free, noninvasive, noncontact neurophysiological procedures. For stimulation, focused mid-infrared light alters membrane potential activates individual processes. Simultaneous intrinsic scattered parameters, including birefringence changes, can with signals similar potentiometric dyes. The simultaneous combination of stimulation recording techniques the for powerful tools that may someday remove need invasive...
To compare failure mode and bending moment of a canine pancarpal arthrodesis construct using either 2.7 mm/3.5 mm hybrid dynamic compression plate (HDCP) or 3.5 (DCP).Paired in vitro biomechanical testing constructs stabilized with 2.7/3.5 HDCP DCP.Paired cadaveric antebrachii (n=5).Pancarpal were loaded to (point maximum load) 4-point materials-testing machine. Using this point failure, moments calculated from system variables for each the 2 plating systems compared paired t-test. examine...
Abstract Background Optical neuronavigation‐guided intracranial surgery has become increasingly common in veterinary medicine, but its use not yet been described horses. Objectives To determine the feasibility of optical biopsy procedures horse, compare standard fiducial array and anatomic landmarks for patient registration, evaluate surgeon experience. Animals Six equine cadaver heads. Methods Computed tomography images each specimen were acquired, with rigidly secured to frontal bone....
A 14-year-old domestic shorthair cat was evaluated for a 3-month history of head pressing and circling. Neurological examination suggested supratentorial problem, predominantly on the left side. An extradural mass extending from rostral frontal lobes caudally to level caudal aspect corpus callosum found with magnetic resonance imaging. bilateral rostrotentorial craniectomy combined sinus performed removal. gamma-irradiated calvarial allograft used repair defect. At 14 months following...
Abstract This report describes surgical decompression and stabilization of 2 hemivertebrae in a German shepherd dog. Long‐term clinical imaging outcomes are documented. Spinal cord via corpectomy improved neurological function intrinsic spinal changes on MRI. The dog to have minimal paraparesis an active lifestyle.
Optical methods to stimulate and record neural activity provide artifact free noncontact neurophysiological procedures. Focused mid-infrared light alters membrane potential activates individual processes; simultaneous intrinsic scattered changes report patterns.