A5044788722- Veterinary Orthopedics and Neurology
- Lysosomal Storage Disorders Research
- Spinal Dysraphism and Malformations
- Cannabis and Cannabinoid Research
- Cerebrospinal fluid and hydrocephalus
- Assisted Reproductive Technology and Twin Pregnancy
- Clinical Laboratory Practices and Quality Control
- Trypanosoma species research and implications
- Toxoplasma gondii Research Studies
- Virus-based gene therapy research
- Head and Neck Surgical Oncology
- Neurological and metabolic disorders
- Adenosine and Purinergic Signaling
- Orthopedic Infections and Treatments
- Cardiovascular Conditions and Treatments
- Forensic Toxicology and Drug Analysis
- Hemoglobinopathies and Related Disorders
- Retinal Development and Disorders
- Herpesvirus Infections and Treatments
- Renal Transplantation Outcomes and Treatments
- Veterinary Equine Medical Research
- Hematopoietic Stem Cell Transplantation
- Tendon Structure and Treatment
- Infectious Diseases and Tuberculosis
- Cerebral Palsy and Movement Disorders
University of Missouri
2013-2021
Missouri College
2013-2021
Silicon Valley University
2021
New York State College of Veterinary Medicine
2019-2020
Cornell University
2019-2020
University of Tennessee at Knoxville
2011
AAV-mediated gene transfer to ependymal cells in a dog model of Batten disease provides sustained enzyme replacement and delays onset.
The CLN2 form of neuronal ceroid lipofuscinosis is a neurodegenerative disease that results from mutations in the TPP1 gene. Affected children exhibit progressive declines most neurological functions including vision. Functional are accompanied by brain and retinal atrophy. encodes soluble lysosomal enzyme tripeptidyl peptidase-1 (TPP1). Dachshunds with null mutation disorder very similar to human disease. Periodic infusion recombinant protein or single injection gene therapy vector into...
CLN2 neuronal ceroid lipofuscinosis is a hereditary lysosomal storage disease with primarily neurological signs that results from mutations in TPP1, which encodes the enzyme tripeptidyl peptidase-1 (TPP1). Studies using canine model for this disorder demonstrated delivery of TPP1 to cerebrospinal fluid (CSF) by intracerebroventricular administration an AAV-TPP1 vector resulted substantial delays onset and progression prolongation life span. We hypothesized treatment may not deliver...
Mycophenolate mofetil (MMF) is recommended as an alternative/complementary immunosuppressant. Pharmacokinetic and dynamic effects of MMF are unknown in young‐aged dogs. We investigated the pharmacokinetics pharmacodynamics single oral dose metabolite, mycophenolic acid (MPA), healthy juvenile dogs purpose‐bred for tripeptidyl peptidase 1 gene ( TPP1 ) mutation. The were heterozygous mutation (nonaffected carriers). Six received 13 mg/kg two placebo. parameters derived from plasma MPA...
Objectives of this study were to adapt a commercial human protein C (PC) colorimetric assay for use in dogs and investigate effects various storage conditions. The was modified by using pooled canine plasma calibration increasing the activation time. PC activity measured fresh stored under some samples significantly different from that plasma; however, differences small. No difference detected similar conditions but analyzed laboratories methodology. Results indicate is suitable if used...
Abstract Background Degenerative myelopathy (DM) in dogs shares similarities with superoxide dismutase 1‐associated human amyotrophic lateral sclerosis (ALS). Brain microstructural lesions are quantified using diffusion tensor imaging (DTI) ALS patients. Objective Characterize brain neurodegenerative changes DM‐affected DTI. Animals Sixteen and 8 control dogs. Methods Prospective observational study. DTI was performed at baseline every 3 months on compared to controls. Fractional anisotropy,...
Physiologic nystagmus was present bilaterally.
Abstract Syringobulbia is a pathologic condition characterized by one or more fluid‐filled cavities within the brainstem. This retrospective case series describes observations in eight dogs with syringobulbia diagnosed during MRI. All were adult, small‐breed concurrent syringomyelia and neurologic deficits localized to sites rostral spinal cord, which cannot be explained (eg, six had vestibular signs). On MRI, signal intensity characteristics like cerebrospinal fluid, medulla oblongata,...