Development of biocompatible and bioactive drug-loaded sutures is considered as an effective but challenging strategy for the wound healing process by delivering biological drugs (e.g., antibiotics) or growth factors bFGF) at surgical sites. Conventional offline suture strategies often lead to fast uncontrollable release sites, rendering become a longer painful patients. Herein, we propose online fabricate electrospun polycaprolactone (PCL) fibrous yarns, incorporated with both collagen...

The formation of inclusion complexes between the cucurbit[7]uril host and a cationic guest containing ferrocenylmethyl adamantyl residues connected to an ammonium nitrogen initially leads ~1:1 mixture two isomeric microscopic complexes, which evolves as function time toward thermodynamically stable mixture, dominated by adamantyl-included complex.

Abstract Research on the chemistry of cucurbit[ n ]uril (CBn) hosts has picked up and maintained an impressive pace in last decade, primarily due to isolation with relatively larger cavity sizes, such as CB7 CB8. This review article summarizes our involvement this research effort, particular emphasis binding redox active guests by CB8 hosts. The 4,4′‐bipyridinium (viologen) derivatives was starting point CB research. While methylviologen is encapsulated CB7, forming a highly symmetric...

The binding interactions between two paramagnetic cobaltocenium guests and the hosts cucurbit[7]uril (CB7) cucurbit[8]uril (CB8) were investigated using a combination of electronic absorption, NMR, electron resonance (EPR) spectroscopies, mass spectrometry, X-ray crystallography. Guest 1, (4-amido-2,2,6,6-tetramethylpiperidine-1-oxyl)cobaltocenium, forms very stable inclusion complexes with CB7 CB8. However, interacts 1 by including organometallic unit, while CB8 engulfs TEMPO residue....

The objective of this study is to evaluate the psychosocial impact dental aesthetics in undergraduate students People's Republic China and investigate association between normal orthodontic treatment needs, aesthetics, desire for treatment.A cross-sectional was carried out two universities a city with 374 young adults aged 19 years 24 years. answered Chinese version Psychosocial Impact Dental Aesthetics Questionnaire (PIDAQ) addressed their treatment. Objective malocclusion severity assessed...

Polyelectrolyte multilayers derived from poly(diallyldimethylamonium chloride) and poly(sodium 4-styrenesulfonate) have been deposited onto poly[1-(trimethylsilyl)-1-propyne] (PTMSP) with anchoring layers formed by Langmuir-Blodgett self-assembly methods. Using gas permeation selectivity as a basis for judging the efficacy of each method, we found that similar CO2/N2 selectivities (ranging 110 to 140) could be achieved both methods their permeances were also similar. Although LB anchors...

Zwitterionic hydrogels are promising biomaterials because of their high water content, three-dimensional network structure, and antifouling property. However, it still remains unclear about how mechanical properties zwitterionic affect In this work, we propose a simple, thermal-pretreatment method to fabricate poly(sulfobetaine methacrylate) (pSBMA) with varied that can be readily tuned by thermal pretreatment time cross-linker density, as well correlate property The resulting...

In quarantine: Nitroxide spin probes are encapsulated by hexameric resorcinarene molecular capsules in dichloromethane solutions (see picture). A substantial reduction the tumbling rates occurs upon encapsulation of two cationic and one neutral probe. As volume probe increases, rate reflects overall entire supramolecular assembly.

The binding properties of the cucurbit[7]uril host with three structurally related ferrocene-containing guests, ferrocenyltrimethylammonium, ferrocenylmethyltrimethylammonium and ferrocenylethyltrimethylammonium, have been investigated using (1)H NMR spectroscopy, mass spectrometry, voltammetry computational methods. experimental data indicate that stability inclusion complexes is relatively insensitive to number methylenes connecting trimethylammonium ferrocenyl groups, although some their...

The extent of methylation the central nitrogen in (ferrocenylmethyl)tempammonium guests determines main binding site for complexation by cucurbit[8]uril host.

Biodegradable hydrogel as a wound dressing and therapeutic prodrug promoting regeneration through enhanced angiogenesis epithelialization.

Tetrathiafulvalene (TTF) is trapped inside a dimeric capsule formed by two octaacid, deep-cavity cavitands in aqueous solution. While the first one-electron oxidation of TTF strongly hindered encapsulation, capsular assembly eventually destabilized upon guest.

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA 7 nm Thick Polymeric Membrane With a H2/CO2 Selectivity of 200 That Reaches the Upper BoundMinghui Wang, Song Yi, Vaclav Janout, and Steven L. Regen*View Author Information Department Chemistry, Lehigh University, Bethlehem, Pennyslvania 18015, United States*E-mail: [email protected]Cite this: Chem. Mater. 2013, 25, 19, 3785–3787Publication Date (Web):September 18, 2013Publication History Received21 August 2013Revised16 September...

To expound the roles of mTOR and NF-kB signaling pathway in intermittent hypoxia (IH)-induced damage hippocampal neurons.For rat experiments, inhibitor (Rapamycin, Rapa) NF-κB (ammonium pyrrolidine dithiocarbamate, PDTC) were applied to inhibit signaling, respectively. For neuron neurons from successfully cultured. Different concentrations Rapa PDTC added cultured neurons. Rat or primary exposed normoxic IH conditions after administration PDTC. The effects on learning memory ability rats...

Until now, Z-form RNAs were believed to only adopt a left-handed double-helix structure. In this study, we describe the first observation of right-handed RNA in NMR solution formed by L-nucleic acid and present resolution structure complex between curaxin ligand. These results provide platform for design topology specific Z-form-targeting compounds are valuable development new potent anticancer drugs.

A chimeric PCV1-2 clone containing the PCV2 capsid gene cloned into backbone of nonpathogenic PCV1 genome was recently generated based on and strains isolated in China. The efficacy this available candidate inactivated vaccine evaluated by subjecting conventional pigs to intramuscular immunization with virus, followed challenge wild-type strain. By 35 days post-vaccination (DPV), all vaccinated had developed seroconversion, having high indirect immunofluorescence assay (IFA) titers antibody...

This work focuses on the effect of cucurbit[n]uril (CBn) hosts microenvironment molecular subunits that are located adjacent to CBn binding site in inclusion complexes. The set data presented here includes previously reported electrochemical and electron paramagnetic resonance spectroscopic data, primarily obtained with ferrocene-containing guests, as well new recorded 4,4′-bipyridinium (viologen) derivatives. Most were cucurbit[7]uril (CB7) complexes, rest collected cucurbit[8]uril (CB8)...

EPR experiments in water-saturated CH2Cl2 solution clearly indicate that oxotempo is not included inside hexameric molecular capsules of resorcin[4]arene. In fact, the tumbling rate only experiences minor changes when resorcinarene present solution. However, NMR spectroscopic data suggest engages labile hydrogen-bonding interactions with water molecules interacting capsules.

A series of polycations bearing one, two, and three pendant quaternary ammonium groups per repeat unit has been synthesized combined with poly(sodium 4-styrenesulfonate) to produce hyperthin polyelectrolyte multilayers. Incremental addition leads decreased permeances for H2, CO2, N2 increased H2/CO2 CO2/N2 permeation selectivities. These results, together analysis the composition from X-ray photoelectron spectra values Young's modulus nanoindentation analysis, show that oligo ions provide a...

A series of polyanions and polycations have been synthesized from atactic, syndiotactic, isotactic forms poly(methyl methacrylate) used to construct polyelectrolyte multilayers (PEMs). Polymer tacticity has found a large influence on film growth but only slight effect H2/N2 permeation selectivities no significant CO2/N2 selectivities. The permeances H2, CO2, N2 across those PEMs exhibiting the highest were vary by as much factors 3, 6, 5, respectively, depending tacticities employed. simple...

The concept of splayed, hyperthin polyelectrolyte multilayers (PEMs) is introduced in which a bulky, hydrophilic and charged pendant group used to increase the gas permeability PEM without reducing its permeation selectivity.

A series of polyelectrolyte multilayers (PEMs) has been fabricated using polyanions and polycations that have repeat units (i) similar in structure composition (matched), (ii) partially (semimatched), (iii) very different (mismatched). The primary aim this investigation was to determine whether the matching polyelectrolytes can significantly influence permeability properties hyperthin PEMs. While matching, per se, not found be a key factor defining membrane permeability, large differences...

The inclusion of three bulky guests, adamantyl(ferrocenylmethyl)amine (2), adamantylferrocenecarboxylamide (3), and 1,1'-bis(adamantylaminomethyl)ferrocene (4), inside dimeric molecular capsules formed by an octaacid deep-cavity cavitand (1) was investigated using (1)H NMR spectroscopy voltammetric techniques. Guests 2 3 were encapsulated 1(2) assemblies, as evidenced spectroscopic data. Although both guests are electroactive, the supramolecular complexes 2@1(2) 3@1(2) showed no current...