A5058129212- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- COVID-19 and healthcare impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Trauma and Emergency Care Studies
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Inflammatory Biomarkers in Disease Prognosis
- Polyomavirus and related diseases
- Microbial Inactivation Methods
- Biomarkers in Disease Mechanisms
- Intestinal and Peritoneal Adhesions
- Respiratory Support and Mechanisms
- MicroRNA in disease regulation
- Surgical Simulation and Training
- Cardiac Health and Mental Health
- Pancreatic and Hepatic Oncology Research
- Surgical site infection prevention
- Minimally Invasive Surgical Techniques
- Healthcare cost, quality, practices
- Cancer Research and Treatments
- Ureteral procedures and complications
- Advances in Oncology and Radiotherapy
Gateshead Health NHS Foundation Trust
2019-2024
Queen Elizabeth Hospital
2020-2024
University of Birmingham
2020-2022
Institut de Virologie
2020-2021
AstraZeneca (Brazil)
2020
Stryker (United Kingdom)
2020
Pfizer (United Kingdom)
2020
Merck (Germany)
2020
Queen Elizabeth Hospital
2020
National and Kapodistrian University of Athens
2011-2014
Preoperative cardiopulmonary exercise testing (CPET) provides an objective measure of a patient’s functional capacity under stress. However, the association between CPET and long-term outcomes for women with ovarian cancer have not been assessed. The aim was to determine whether cardiorespiratory fitness, as measured by parameters—peak oxygen uptake (VO2 peak), ventilatory efficiency at anaerobic threshold (VE/VCO2 AT), (AT)—could predict overall survival (OS) recurrence -free (RFS) in...
Sarcoidosis is an inflammatory disease, which may affect vascular function. The study was designed to assess the impact of sarcoidosis on endothelial function and arterial stiffness.Eighty-seven patients eighty-seven matched healthy subjects (Cl) were included in study. divided into two groups. Group 1 never treated group 2 receiving cortisone treatment. Endothelial evaluated by flow-mediated dilatation (FMD). Carotid-femoral pulse wave velocity (PWV) measured as index aortic stiffness...
Leiomyomas growth involves cellular hypertrophy, modulation of mitotic activity and upregulation extracellular matrix (ECM). Vascular factors metalloproteinases (MMPs) play a coordinated role during neoplasia tissue remodeling. The present study investigates the angiogenic factor vascular endothelial (VEGF)-A with main gelatinases, MMP-2/MMP-9 their inhibitor TIMP-1 in patients leiomyomas.Peripheral blood 46 women uterine leiomyomas was obtained prior hysterectomy to assess VEGF-A, MMP-2,...
<h3>Objective</h3> Splenectomy with or without distal pancreatectomy may be necessary at time of cytoreductive surgery to achieve complete cytoreduction in advanced ovarian cancer. However, these procedures have been associated peri-operative morbidity. The aims this study were determine the incidence among patients undergoing splenectomy during for cancer and incidence, management, treatment, prognosis post-operative pancreatic fistula. <h3>Methods</h3> Retrospective cohort all consecutive...
<h3>Introduction/Background</h3> Blood inflammatory composite markers play significant role in the prognostication of various malignancies. Our study aims to assess neutrophil-to-lymphocyte(NLR),platelet-to-lymphocyte(PLR), monocyte-to-lymphocyte(MLR)ratios and systemic inflammation index(SII) determining progression free survival(PFS) patients with advanced stage high grade serous ovarian cancer(HGSOC). Secondary outcomes include assessing their reliability predicting extension disease,...
<h3>Introduction/Background</h3> Historically, patients treated for epithelial ovarian cancer (EOC) undergo long-term hospital-based follow-up with serial serum CA125 (sCA125) measurement. It is however unclear whether earlier detection of recurrence through sCA125 monitoring alters survival. This uncertainty reflected in the variances practices. The aim this study was to investigate predictive value at stratified by tumour (tCA125) status diagnosis, determined immunohistochemistry....
<h3></h3> <sup>3</sup>Department of Gynecologic Oncology, ARNAS Ospedali Civico Di Cristina Benfratelli, University Palermo, Italy <h3>Introduction</h3> The aim this study was to assess the prognostic role and peri-operative outcomes conization performed before radical hysterectomy in early-stage cervical carcinoma. <h3>Methods</h3> Multi-center retrospective observational cohort including patients with FIGO 2009 IB1 carcinoma treated between 06/2004 06/2019. Patients were divided into two...
<h3>Introduction/Background</h3> The transition from an established laparoscopic practice to the new robotic era is challenging for surgeons and service. Our aim evaluate learning curve of a pioneer surgeon through development service using Da Vinci-XI-system (DaVinci-XI; Intuitive Surgical Ltd) in Gynaecological Oncology, focused on patients' safety outcomes. <h3>Methodology</h3> All cases (n=27) performed Northern Oncology Centre (NGOC), QE Hospital, Gateshead have been identified...
<h3>Introduction/Background</h3> Standard surgical management for borderline ovarian tumours (BOT) is the complete tumour resection with adequate staging including peritoneal biopsies, cytology and, at least, infracolic omentectomy but there increasing evidence that completion of procedures (COS) do not reduce risk recurrence or increases overall survival. Our aim to explore role in BOT focused on oncological outcomes and peri-operative safety. <h3>Methodology</h3> All patients...
<h3>Introduction/Background</h3> Bowel obstruction (BO) is an infrequent but challenging complication of gynaecological cancer. Management may be surgical, medical or conservative, there a lack evidence-based guidance to inform best practice. This study aimed review BO management in patients with malignancy. <h3>Methodology</h3> In this retrospective all admitted the NGOC radiological evidence (2012–2017) were identified. Patient demographics, clinicopathological data and details collated....
<h3>Introduction/Background</h3> In the phase III LACC cervical cancer trial, shorter disease-free survival and overall was observed in patients treated with minimally invasive radical hysterectomy comparison to traditional open surgery. One hypothesis for this difference is an adverse effect of prolonged exposure hypoxic, CO<sub>2</sub>-rich, acidotic environment created during Greater tumour hypoxia-inducible factor 1α (HIF-1α) indicating tissue hypoxia has previously been shown be a...
<h3>Introduction/Background</h3> Controversies in stage IA cervical cancer include 1) need for radical treatment IA2 disease, 2) lymphadenectomy LVSI positive cases, 3) reflex hysterectomy as 1ry or delayed after fertility completion. These controversies are highlighted by a trend towards conservative consisting solely of loop excision. We present the largest series policy cancer. <h3>Methodology</h3> A cross-referenced analysis utilising national and organisational databases was performed...
<h3>Introduction</h3> ECT utilises pulsed electrical current to transiently increase cell membrane permeability the cytotoxic agent, bleomycin. We present use of in patients with recurrent gynaecological malignancy previously treated a combination surgery or radiotherapy, experiencing symptoms from cutaneous lesions. This report presents evidence role for second and third line treatment. <h3>Methods</h3> Between July 2017 August 2019, 6 recurrence (5 vulvar SCC 1 high grade serous ovarian...
<h3>Introduction/Background</h3> ECT utilises pulsed electrical current to transiently increase cell membrane permeability the cytotoxic agent, bleomycin. We present use of in patients with recurrent gynaecological malignancy previously treated a combination surgery or radiotherapy, experiencing symptoms from cutaneous lesions. This report presents evidence role for second and third line treatment. <h3>Methodology</h3> Between July 2017 August 2019, 6 recurrence (5 vulvar SCC 1 high grade...