A5082499697- Alzheimer's disease research and treatments
- Gut microbiota and health
- Probiotics and Fermented Foods
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Lymphoma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Dementia and Cognitive Impairment Research
- Chronic Myeloid Leukemia Treatments
- Epigenetics and DNA Methylation
- Microbial Metabolites in Food Biotechnology
- Immunodeficiency and Autoimmune Disorders
- Pharmacology and Obesity Treatment
- Gastrointestinal motility and disorders
- HIV/AIDS oral health manifestations
- Cholinesterase and Neurodegenerative Diseases
- Prion Diseases and Protein Misfolding
- Child Nutrition and Feeding Issues
- Infant Nutrition and Health
- Ecology and Vegetation Dynamics Studies
- Muscle metabolism and nutrition
- Parkinson's Disease Mechanisms and Treatments
AB-Biotics (Spain)
2020-2024
Universitat de Barcelona
2018-2022
University of Graz
2016-2019
QPS (Austria)
2016-2019
Universitat Autònoma de Barcelona
2016
Harvard University
2002
Dana-Farber Cancer Institute
2002
Hospital General De Segovia
1993
Aging-related tau astrogliopathy (ARTAG) is defined by the presence of two types tau-bearing astrocytes: thorn-shaped astrocytes (TSAs) and granular/fuzzy in brain old-aged individuals. The present study focused on TSAs rare forms ARTAG with no neuronal pathology or restricted to entorhinal transentorhinal cortices, avoid bias from associated tauopathies. show 4Rtau phosphorylation at several specific sites abnormal conformation, but they lack ubiquitin are not immunostained tau-C3...
Introduction: Human tau seeding and spreading occur following intracerebral inoculation into different gray matter regions of brain homogenates obtained from tauopathies in transgenic mice expressing wild or mutant tau, wild-type (WT) mice. However, little is known about propagation the white matter. Objectives: The present study geared to learning patterns cells involved unilateral corpus callosum sporadic Alzheimer's disease (AD), primary age-related tauopathy (PART: neuronal 4Rtau 3Rtau),...
Probiotics with high bile salt hydrolase (BSH) activity have shown to promote cardiovascular health. However, their mechanism(s) of action remain poorly understood. Here, we performed a pilot exploratory study investigate effects 4-week intervention escalating doses BSH-active formula containing Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 on acid (BA), lipid profile, lipoprotein function.
Background Some HIV-1 infected patients are unable to completely recover normal CD4+ T-cell (CD4+) counts after achieving suppression with combined Antiretroviral Therapy (cART), hence being classified as immuno-discordant. The human microbiome plays a crucial role in maintaining immune homeostasis and is potential target towards reconstitution. Setting RECOVER (NCT03542786) was double-blind placebo-controlled clinical trial designed evaluate if the novel probiotic i3.1 (AB-Biotics, Sant...
Human tau seeding and spreading occur following intracerebral inoculation of brain homogenates obtained from tauopathies in transgenic mice expressing natural or mutant tau, wild-type (WT) mice. The present study was geared to learning about the patterns seeding, cells involved characteristics primary age-related tauopathy (PART: neuronal 4Rtau 3Rtau), aging-related astrogliopathy (ARTAG: astrocytic 4Rtau) globular glial (GGT: with deposits specific inclusions astrocytes oligodendrocytes)....
Abstract Ecotones linking open and forested habitats contain multiple microhabitats with varying vegetal structures microclimatic regimes. host many insect species whose development is intimately linked to the conditions where they grow (e.g., leaves of their plants surrounding air). Yet heterogeneity at these fine scales its effects on insects remain poorly quantified for most species. Here we studied how interspecific differences in use across ecotones lead contrasting thermal exposure...
Functional gastrointestinal disorders (FGIDs) are a common concern during the first year of life. Recognized as gut-brain axis by Rome IV criteria, FGIDs etiology is linked to altered interaction, intestinal physiology, and microbiota. In this regard, probiotics have emerged promising therapy for infant FGIDs. study, we investigated probiotic potential strains Bifidobacterium longum KABP042 Pediococcus pentosaceus KABP041—isolated from healthy children’s feces—in treatment To scope, genome...
// Noelia Purroy 1, * , Júlia Carabia Pau Abrisqueta 1 Leire Egia Meritxell Aguiló Cecilia Carpio Carles Palacio Marta Crespo Francesc Bosch Laboratory of Experimental Hematology, Department Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Spain These authors contributed equally to this work Correspondence to: Crespo, email: macrespo@vhebron.net Keywords: CLL, Syk, microenvironment, TAK-659, BCR inhibitor Received: May 18, 2016 Accepted: November Published: 24, ABSTRACT...
Declines in estrogen levels occur women transitioning to menopause. Estrogen hormones play important roles multiple systems of the body, and loss is associated with a variety symptoms that can decrease quality life. The gut microbiota involved regulating endogenous levels. A portion glucuronides be reactivated by microbial enzyme β-glucuronidase, resulting free estrogens return bloodstream. Here, we carried out
In this study, we have compared the cellular pathology associated with β‐amyloid (βA) deposits which characterize Alzheimer's disease (AD) in demented patients pathologically confirmed AD, that non‐demented aged individuals. Brain sections from two severely AD cases, six individuals βA deposits, and age‐matched controls devoid of were double‐immunostained antibodies against βA, antibody markers for neurofibrillary tangles (NFT), astrocytes microglial cells. We found displayed numerous...
Obesity is a global public health problem. To evaluate the effect of regular consumption product Lipigo® on body weight and rebound overweight/obese subjects undergoing comprehensive loss program. A randomized, parallel, double-blind, placebo-controlled clinical trial was conducted with male female presenting BMI 25-39.9 kg/m2. All underwent program (WLP) for 12 weeks, which included an individualized hypocaloric diet, physical activity recommendations, nutritional education seminars, three...
Objectives: Gastrointestinal (GI) issues, including constipation, are common among older adults and may be associated with changes in gut microbiota activity or composition. It has been previously shown that Lactiplantibacillus plantarum KABP-31 KABP-32 have a beneficial effect on digestive health adults. The objective of this study was to examine the efficacy probiotic blend containing these two strains (FloradaptTM Mature Immune Defense) GI symptoms, bowel movement (BM) frequency, stool...
Alzheimer's disease (AD) is an irreversible neurodegenerative process in which memory functions, intellectual abilities and reasoning skills are progressively lost. AD brains diagnosed under the co-existence of two main pathological hallmarks: (1) Neurofibrillary tangles (NFT) composed hyperphosphorylated Tau aggregates, (2) senile plaques comprising insoluble β-amyloid (Aβ). Mentioned events do not develop same brain region; while NFT production starts entorhinal transentorhinal cortex, Aβ...
Alzheimer’s Disease (AD) is the most common neurodegenerative disorder worldwide causing dementia in aged people. Brains from AD patients are characterized by two main pathological hallmarks: (1) Neurofibrillary tangles (NFT) consisting of hyperphosphorylated Tau aggregates, and (2) senile plaques comprising insoluble β-amyloid (Aβ). Thus a mouse model co-producing both Aβ would be well suitable to mimic AD. To generate such we for first time virally induced expression with prevailing...
Due to the lack of proper biomarkers, in vivo diagnosis Alzheimer's disease (AD) pathology patients is still not possible. Major hallmarks AD comprising extracellular plaque deposits β-amyloid peptide (Aβ), Tau neurofibrillary tangles and neuroinflammation are concomitantly occurring only brain, but also other sensory systems such as retina. Interestingly, a promising clinical study supervised by Dr. Koronyo-Hamaoui was published 2017 providing opportunity detect track Aβ retina living...
Alzheimer's disease (AD) brains are diagnosed under the concomitant expression of two main pathological hallmarks: (2) Neurofibrillary tangles (NFT) composed hyperphosphorylated Tau aggregates, and senile plaques comprising insoluble β-amyloid (Aβ). Mentioned events do not develop in same brain region; while NFTs production starts entorhinal transentorhinal cortex, Aβ plaque aggregation begins neocortex. Moreover, onset both pathologies is triggered at time. Unfortunately, current use...
Alzheimer's disease (AD) is the most common form of neurodegenerative dementia. Major hallmarks are: (1) extracellular plaque deposits β-amyloid peptide (Aβ) and (2) intracellular neurofibrillary tangles phosphorylated tau. Published research suggests an association between AD functional impairments sensory systems. In fact, occurrence tau-mediated glaucoma has been reported, as well protein-associated neuropathology in To explore mechanisms investigate features AD-related pathological...