A5061423493- Dermatological diseases and infestations
- Immune cells in cancer
- Plant and animal studies
- Insect and Arachnid Ecology and Behavior
- Sulfur Compounds in Biology
- Study of Mite Species
- Hemiptera Insect Studies
- Fossil Insects in Amber
- Insect-Plant Interactions and Control
- Insects and Parasite Interactions
- Neurobiology and Insect Physiology Research
- Amphibian and Reptile Biology
- Animal Ecology and Behavior Studies
- Yersinia bacterium, plague, ectoparasites research
- Animal Behavior and Reproduction
- Fire effects on ecosystems
- Forest Insect Ecology and Management
- Mollusks and Parasites Studies
- Vector-borne infectious diseases
- Forest Ecology and Biodiversity Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Fatty Acid Research and Health
- Wildlife Ecology and Conservation
- Adipose Tissue and Metabolism
- Folate and B Vitamins Research
University Hospital Heidelberg
2024
Heidelberg University
1990-2024
University of Bergen
2009-2023
Saxon Academy of Sciences and Humanities in Leipzig
2003-2008
Friedrich Schiller University Jena
2003-2007
Trinity College Dublin
1998
German Cancer Research Center
1987-1994
DKFZ-ZMBH Alliance
1987-1994
Institute of Immunology
1990-1991
Even a moderate increase in the cellular cysteine supply elevates intracellular glutathione (GSH) and disulfide (GSSG) levels potentiates immunological functions of lymphocytes vitro. At low GSSG levels, T cells cannot optimally activate immunologically important transcription factor NF kappa B, whereas high inhibit DNA binding activity B. The effects are antagonized by reduced thioredoxin (TRX). As protein tyrosine kinase activities p56lck p59fyn activated intact hydrogen peroxide, they...
HIV-infected individuals and SIV-infected rhesus macaques have, on the average, decreased plasma cysteine cystine concentrations intracellular glutathione levels. We show that supply levels have a strong influence T cell system, A study of healthy human subjects revealed persons with 20-30 nmol/mg protein had significantly higher numbers CD4+ cells than either lower or Persons who moved during 4-weck observation period from optimal to suboptimal range (10-20 nmol/mg) experienced, 30%...
Abstract Wolbachia bacteria, vertically transmitted intracellular endosymbionts, are associated with two major host taxa in which they show strikingly different symbiotic modes. In some of filarial nematodes, where strictly obligately beneficial to the host, complete within- and among-species prevalence as well co-phylogeny their hosts. arthropods, usually parasitic; if effects occurs, can be facultative or obligate, related reproduction. varies within among taxa, no co-speciation events...
Abstract Background Neuropeptide ligands have to fit exactly into their respective receptors and thus the evolution of coding regions genes is constrained may be strongly conserved. As such, they suitable for reconstruction phylogenetic relationships within higher taxa. CAPA peptides major lineages cockroaches (Blaberidae, Blattellidae, Blattidae, Polyphagidae, Cryptocercidae) termite Mastotermes darwiniensis were chosen test above hypothesis. The various groups taxon Dictyoptera (praying...
The insect order Mantophasmatodea was described in 2002. Prior to that time, several generations of entomologists had assumed all major taxa were known; thus, its description a sensation for zoologists. Since then, surprising abundance and species diversity this taxon have been found, particularly the winter rainfall region South Africa. To learn more about evolutionary lineages, speciation, biogeography Mantophasmatodea, we applied an unusual peptidomics approach. We collected specimens...
FMRFamides belong to the most extensively studied neuropeptides in invertebrates and exhibit diverse physiological effects on different target organs, such as muscles, intestine nervous system. This study American cockroach confirms for first time that extended occur non-dipteran insects. By means of tandem mass spectrometry, these were structurally elucidated, sequence information was used subsequent cloning FMRFamide gene. precursor gene encodes 24 putative peptides shows sufficient...
The spectacular discovery of the new insect order Mantophasmatodea in 2002 was immediately followed by detailed studies on morphology and scattered information different aspects its behavior general biology. A distinct feature these predatory insects is development large arolia, which are typically held upright; hence, their common name heelwalkers. first mantophasmatodean species were described based two museum specimens originally collected Tanzania Namibia. To date, have been observed at...
Abstract The concentration of L‐lactate in the blood plasma higher vertebrates is about 1 mM but can be as high 30 under certain physiological and pathological conditions or vicinity glycolytically active cells including macrophages. Here we report that physiologically relevant concentrations lactate increase expression interleukin 2 (IL 2)‐specific mRNA production IL2 activity cultures mitogenically stimulated T cells. Lactate supports IL most effectively if added 0–8 h after cell...
Tachykinins and tachykinin‐related peptides (TKRPs) play major roles in signaling the nervous system intestine of both invertebrates vertebrates. Here we have identified cDNAs encoding precursors multiple TKRPs from cockroaches Leucophaea maderae Periplaneta americana . All nine LemTKRPs that had been chemically isolated earlier experiments could be on precursor L. Four previously unidentified were found addition precursor. The P. cDNA displayed an open reading frame very similar to with 13...
Abstract The genera Cimex Linnaeus and Oeciacus Stål (Heteroptera: Cimicidae) are common haematophagous ectoparasites of bats or birds in the Holarctic region. Both their phylogenetic relationship systematics entire family previously were based on data from morphology host relationships. Relationships among nine species genus three analysed here using two mitochondrial nuclear genes. was shown to be paraphyletic with respect . is thus proposed as a synonym characteristic phenotype results...
The present distribution of the invasive slug Arion vulgaris Moquin-Tandon was studied in Norway. This important pest species has spread to many parts Europe during last decades, inflicting damage agriculture and domestic gardens. It first recorded Norway 1988, since country is now 192 municipalities. We surveyed current by sampling gathering records cooperation with garden societies local authorities. Based on these records, we distributional data as well relative predictions future...
(1) We document the invertebrate fauna collected from 24 oak canopies in east and west Norway as a contribution to Norwegian Biodiversity Information Centre’s ‘The Taxonomy Initiative’. (2) A snap-shot inventory of was recorded by means emitting mist natural pyrethrum into at night using petrol-driven fogger collecting specimens butterfly nets spread on ground under canopy. (3) Almost entire catch more than 6800 identified 722 species. Out 92 species new fauna, 21 were science and,...
Abstract Rapid genitalia evolution is believed to be mainly driven by sexual selection. Recently, noncopulatory genital functions have been suggested exert stronger selection pressure on female than copulatory functions. In bedbugs (Cimicidae), the impact of function can isolated from impact. Unlike in other taxa, organs no egg-laying or waste-product expulsion. Males perform traumatic mating piercing integument, thereby imposing antagonistic females and suspending morphologically match...
We investigated sperm storage by females of a predatory bug, Nabis rugosus, before and after hibernation with regard to nutritional status. In the field, had more available than hibernation. Food-deprived maintained fewer fed but not However, food-deprived suppressed egg production rather decreasing sperm-storage efficiency. Because mated did exhibit increased overwinter survival relative virgin there is low likelihood direct benefits in form ejaculate-derived nutrients. If...
Arion vulgaris Moquin-Tandon 1855 is one of the most important invasive species in Europe, affecting both biodiversity and agriculture. The spreading many parts inflicting severe damage to horticultural plants cultivated crops partly due a lack satisfactory effective management solutions. Molluscicides have traditionally been used manage slug densities, although effects are variable some side-effects on other biota. Thus, there need explore potential alternatives such as biological control....
The last decades have shown a surge in studies focusing on the interplay between fragmented habitats, genetic variation, and conservation. In present study, we consider case of temperate pond-breeding anuran (the common toad Bufo bufo) inhabiting naturally strongly habitat at Northern fringe species' range: islands offshore Norwegian coast. A total 475 individuals from 19 populations (three mainland 16 seven adjacent islands) were genetically characterized using nine microsatellite markers....