A5033760586- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Palliative Care and End-of-Life Issues
- Autism Spectrum Disorder Research
- Psychosomatic Disorders and Their Treatments
- Autoimmune Neurological Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Traumatic Brain Injury Research
- Acute Ischemic Stroke Management
- Child Nutrition and Feeding Issues
- Artificial Intelligence in Healthcare
- Carcinogens and Genotoxicity Assessment
- Agricultural Economics and Practices
- Grief, Bereavement, and Mental Health
- Biochemical Analysis and Sensing Techniques
- Cellular transport and secretion
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Neuropathies and Disorders
- Identity, Memory, and Therapy
- Mental Health via Writing
- Nuclear Receptors and Signaling
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Telemedicine and Telehealth Implementation
- Healthcare Decision-Making and Restraints
Northwestern University
2019-2025
University of California, San Francisco
2023-2025
Scripps Clinic
2025
Scripps Health
2025
University of Cincinnati
2016-2018
University of Cincinnati Medical Center
2017-2018
Objective: Spiritual well-being (SWB) has been shown to delay the onset of cognitive decline among older adults predisposed Alzheimer's disease and related neurodegenerative dementias. It was, however, unknown if SWB is also associated with in manifestation ("phenoconversion") rare, genetic dementias, such as Huntington's (HD). Thus, we sought evaluate association between phenocovnersion people at-risk for HD. Methods: The "Prospective Huntington At Risk Observation Study" (PHAROS), a...
Clinical signs are critical in ascertaining the functional nature of a gait disorder. Four impairment have been documented course examining patients with clinically definite (psychogenic) movement disorders: "huffing and puffing" during standing walking, manipulation-resistance dorsiflexion first toe, fixed plantar flexion inversion, marked discrepancy between ambulation without swivel chair assistance. While large studies needed to ascertain their prevalence, sensitivity, specificity,...
Objective: Death anxiety, represented by the HDQLIFE™ Concern with and Dying (CwDD) patient-reported outcome (PRO) questionnaire, captures a person's worry about death dying process. Previous work suggests that anxiety remains an unremitting burden throughout all stages of Huntington disease (HD). Although palliative interventions have lessened among people advanced cancer, none has yet to undergo testing in HD population. An account how is associated longitudinal changes aspects...
Stroke is a leading cause of disability and mortality worldwide. Recent advances in stroke care now enable patients with severe ischemic owing to large vessel occlusion safely undergo endovascular thrombectomy (EVT) up 24 hours since their time last known well, the goal improving functional outcomes by recanalization occluded reperfusion downstream brain tissue. The objective this analysis highlight clinical ethical challenges related ensuring goal-concordant era unprecedented acute care....
Background: People with Huntington’s disease (HD) often become institutionalized and more frequently die away from the home setting. The reasons behind differences in end-of-life care are poorly understood. Less than 5% of people HD report utilization palliative (PC) or hospice services, regardless lack curative therapies for this neurodegenerative disease. It is unknown what factors associated in-patient specialty PC consultation population how might be related to discharge disposition....
Previous work in Huntington's disease (HD) has shown that a sense of meaning and purpose (M&P) is positively associated with positive affect well-being (PAW); however, it was unknown whether HD-validated patient-reported outcomes (PROs) influence this association how M&P impacts PROs the future. Our study designed to examine if moderate relationship between PAW evaluate baseline predicts 12- 24-month changes PROs.This longitudinal, multicenter develop several (e.g., specific for physical,...
Noncurative surgeries intended to relieve suffering during serious illness or near end of life have been analyzed across palliative settings. Yet sparse guidance is available inform clinical management decisions about whether
Benzi M. Kluger, MD; Janis Miyasaki, Maya Katz, Nicholas Galifianakis, Kirk Hall, MBA; Steven Pantilat, Ryan Khan, MDiv; Cari Friedman, LCSW; Wendy Cernik, BSN; Yuika Goto, Judith Long, MS; Diane Fairclough, DrPH; Stefan Sillau, PhD; Jean S. Kutner, MD
Parkinson disease is a chronic and multifaceted neurodegenerative disorder that necessitates specialized integrated care. By engaging with multidisciplinary team, including movement disorders specialist, physical therapist, speech-language pathologist, occupational dietician social worker, patients may become familiar and, eventually, adept at skills have the potential to improve quality of life. Many feel overwhelmed by plurality providers involved in management their long-term condition....
Most Parkinson's disease (PD) patients present without known family history and a diagnosed prodromal phase, underscoring the difficulty of employing primary (neuroprevention) secondary (neuroprotection) preventions. In cases monogenic forms, however, potential gene-carrying members proband could engage in neuroprevention, such as exercise or diet modifications, to attenuate risk of, delay, development. However, historical lack recognized disease-modifying interventions has limited...
Background: Individuals with life-limiting illnesses experience psychotherapeutic benefits of transmitting their life's history to loved ones; however, the scope and depth what warrants preservation who ought undertake such activity remains less clear. Furthermore, individuals conditions that afflict brain face barriers regarding timing structure interventions. We analyzed data from an online social media forum understand perceptions legacy-making. Methods: This is a qualitative descriptive...
Most people prefer to die at home. Hospice is the standard in end-of-life care for with Huntington disease (HD), a neurodegenerative genetic disorder that affects middle adulthood. Yet, we have little knowledge regarding place of death HD. Therefore, current state limits HD clinicians' ability conduct high-quality goals conversations.
A 30-year-old healthy man presents after a fall with diffuse weakness and pain recent onset left eye ptosis in the setting of three weeks progressive bilateral leg weakness, gait instability, difficulty washing his hair due to upper extremity weakness. He had also developed stiffness neck shoulders uncontrollable muscle spasms. Exam was notable for ptosis, fatiguing extremities, increased tone, hyperreflexia clonus, spastic gait. mediastinal mass found on chest CT (Fig. 1), biopsy confirmed...
Dementia with Lewy bodies (DLB) is characterized by a triad of core features: fluctuating cognition, visual hallucinations, and parkinsonism; other commonly associated features include REM sleep behavior disorder (RBD) dysautonomia (e.g., orthostatic hypotension, urinary incontinence, constipation, impotence).1 Case-control studies have reported higher prevalence rhinorrhea in patients Parkinson disease (PD) compared to healthy controls.2–6 Of interest, 76% PD exacerbation while eating.2...
A 77-year-old-man presents with chorea, parasomnias, dysarthria and dysphagia, cognitive issues. broad workup reveals positive anti-IgLON5 antibody. This case report represents a textbook example of syndrome.
With Huntington disease (HD), a fatal neurodegenerative where the prevalence of suicidal thoughts and behavior (STB) remains elevated as compared to other neurological disorders, it is unknown whether STB health-related quality life (HRQoL) affect plans for end or more broadly, advance care planning (ACP). Conversely, ACP would provoke future changes HRQoL. Therefore, we sought evaluate HRQoL patient-reported outcomes (PROs) contribute relates in at 24 months.HD-validated clinician-...