A5073605542- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Pancreatic function and diabetes
- Hypothalamic control of reproductive hormones
- Eating Disorders and Behaviors
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Diet and metabolism studies
- SARS-CoV-2 and COVID-19 Research
- Cardiac electrophysiology and arrhythmias
- COVID-19 Clinical Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Sleep and Wakefulness Research
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Dietary Effects on Health
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2024
Instituto Multidisciplinario de Biología Celular
2015-2024
Comisión de Investigaciones Científicas
2017-2024
Universidad Nacional de La Plata
2016-2023
Institute of Cell Biology
2021-2023
Centre National de la Recherche Scientifique
2021
Ghrelin is a stomach-derived octanoylated peptide hormone that plays variety of well-established biological roles acting via its specific receptor known as growth secretagogue (GHSR). In plasma, des-octanoylated form ghrelin, named des-acyl ghrelin (DAG), also exists. DAG suggested to be signalling molecule has targets, including the brain, and regulates some physiological functions. However, no for been reported until now, and, consequently, potential role remained matter debate. present...
Ghrelin is known to act on the area postrema (AP), a sensory circumventricular organ located in medulla oblongata that regulates variety of important physiological functions. However, neuronal targets ghrelin AP and their potential role are currently unknown. In this study, we used wild-type genetically modified mice gain insights into neurons expressing receptor [growth hormone secretagogue (GHSR)] role. We show circulating mainly accesses but not adjacent nucleus solitary tract. Also, both...
The growth hormone secretagogue receptor (GHSR) is a G protein-coupled that highly expressed in the central nervous system. GHSR acts as for ghrelin and liver-expressed antimicrobial peptide 2 (LEAP2), which blocks ghrelin-evoked activity. also displays ligand-independent activity, including high constitutive activity signals absence of reduced by LEAP2. modulates variety food intake-related behaviours, binge eating. Previously, we reported GHSR-deficient mice daily time-limited exposed to...
Binding of ghrelin to its receptor, growth hormone secretagogue receptor (GHSR), stimulates GH release, induces eating, and increases blood glucose. These processes may also be influenced by constitutive (ghrelin-independent) GHSR activity, as suggested findings in short people with naturally occurring GHSR-A204E mutations reduced food intake glucose rodents administered inverse agonists, both which impair activity. In this study, we aimed more fully determine the physiologic relevance We...
The stomach-derived hormone ghrelin regulates essential physiological functions. receptor (GHSR) has ligand-independent actions; therefore, GHSR gene deletion may be a reasonable approach to investigate the role of this system in feeding behaviors and diet-induced obesity (DIO). Here, we effects long-term (12-month) high-fat (HFD) versus regular diet on obesity-related measures global GHSR-KO wild-type (WT) Wistar male female rats. Our main findings are that protects against DIO decreases...
Abstract The hormone ghrelin displays several well-characterized functions, including some with pharmaceutical interest. receptor for ghrelin, the growth secretagogue (GHSR), is expressed in hypothalamic paraventricular nucleus (PVH), a critical hub integration of metabolic, neuroendocrine, autonomic, and behavioral functions. Here, we performed neuroanatomical functional characterization neuronal types mediating actions PVH male mice. We found that fluorescent mainly labels neurons...
Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that display a different tendency consume high fat (HF) diet. For this purpose, used compilation of HF intake data from an experimental protocol in which satiated were exposed pellet every morning 2-h over 4 consecutive days. We found displayed large degree intake. day 1 significantly correlated with successive days, applied hierarchical clustering algorithm on...
Abstract The growth hormone secretagogue receptor (GHSR), primarily known as the for hunger ghrelin, potently controls food intake, yet specific Ghsr-expressing cells mediating orexigenic effects of this remain incompletely characterized. Since Ghsr is expressed in gamma-aminobutyric acid (GABA)–producing neurons, we sought to investigate whether selective expression a subset GABA neurons sufficient mediate GHSR's on feeding. First, crossed mice that express tamoxifen-dependent Cre...
<title>Abstract</title> The stomach-derived hormone ghrelin regulates essential physiological functions. receptor (GHSR) has ligand-independent actions, therefore, <italic>GHSR</italic> gene deletion may be a reasonable approach to investigate the role of this system in feeding behaviors and diet-induced obesity (DIO). Here we investigated effects long-term (12 month) high-fat (HFD) <italic>versus</italic> regular diet on obesity-related measures global GHSR-KO wild type (WT) Wistar male...