A5008775799- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Photoreceptor and optogenetics research
- Electrolyte and hormonal disorders
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
Universidade Federal de São Paulo
2023
Abstract The hormone ghrelin displays several well-characterized functions, including some with pharmaceutical interest. receptor for ghrelin, the growth secretagogue (GHSR), is expressed in hypothalamic paraventricular nucleus (PVH), a critical hub integration of metabolic, neuroendocrine, autonomic, and behavioral functions. Here, we performed neuroanatomical functional characterization neuronal types mediating actions PVH male mice. We found that fluorescent mainly labels neurons...
The cell bodies of hypothalamic magnocellular neurones are densely packed in the supraoptic nucleus, whereas their axons project to anatomically discrete posterior pituitary gland. We have taken advantage this unique anatomical structure establish proteome and phosphoproteome dynamics neuronal axonal terminals response physiological stimulation. found that responses stimulation very different between somatic compartments, indicating need each domain differentially adapt. In particular,...
Ageing is associated with altered neuroendocrine function. In the context of hypothalamic supraoptic nucleus, which makes antidiuretic hormone vasopressin, ageing alters acute responses to hyperosmotic cues, rendering elderly more susceptible dehydration. Chronically, vasopressin has been numerous diseases old age, including type 2 diabetes and metabolic syndrome. Bulk RNAseq transcriptome analysis used catalogue polyadenylated nucleus transcriptomes adult (3 months) aged (18 rats in basal...