A5084625871- Veterinary Pharmacology and Anesthesia
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Veterinary Equine Medical Research
- Diet and metabolism studies
- Digestive system and related health
- Pain Mechanisms and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Neuropeptides and Animal Physiology
- Clinical Nutrition and Gastroenterology
- Respiratory Support and Mechanisms
- Pharmacological Effects and Assays
- Airway Management and Intubation Techniques
- Spine and Intervertebral Disc Pathology
- Anesthesia and Neurotoxicity Research
- Veterinary Practice and Education Studies
- Animal testing and alternatives
- Reproductive Biology and Fertility
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac Arrest and Resuscitation
- Nutrition and Health in Aging
- Veterinary Orthopedics and Neurology
- Neonatal Respiratory Health Research
- Effects of Radiation Exposure
- Ovarian function and disorders
Universidad Complutense de Madrid
2016-2025
Universidad de Extremadura
2022
IVI Madrid Clinic
2010-2021
Université de Montréal
2014-2015
Universidade Federal do Rio de Janeiro
2015
Uppsala University Hospital
2013
University of California, Davis
2011-2012
Clinica Rotger
2004-2012
Poznan University of Medical Sciences
2010-2011
Vanderbilt University
2011
Objective—To determine the analgesic, sedative, and cardiopulmonary effects of epidural ketamine in horse. Animal Population—Six healthy horses (three males three females) weighing between 350 450 kg. Methods—Three doses were selected (0.5, 1, 2 mg/kg). Two months before beginning experiments, carotid artery was exteriorized, 1 week experiments began, an catheter placed percutaneously all animals with tip located 12 cm cranially midsacrum. One later, either saline (control) or one injected...
Assessing and alleviating pain in animals involved research is critically important. However, the effective implementation of management depends on knowledge attitudes personnel involved. Following a Federation European Laboratory Animal Science Associations ‘Pain Mice’ working group initiative, questionnaire to survey current practices concerning analgesic use laboratory mice was distributed several professional groups field animal science. Besides demographic data, analgesia sources...
Summary Veterinary professionals working in partnership with other competent persons are essential for a successful animal care and use programme. A veterinarian's primary responsibilities defined by their own professional regulatory bodies, but this area of work there further opportunities contribution, which will assist safeguarding the health welfare animals used research. These guidelines aimed not only at veterinarians to explain duties, outline improve under care, also employers...
Alfaxalone is a neuroactive steroid used as general anaesthetic in several species including dogs, cats, rabbits and ferrets. It has wide margin of safety similar profile to propofol. To increase its aqueous solubility, new formulation with cyclodextrins been marketed recently. The objective this study was evaluate the effect doses alfaxalone alone, considering differences between sexes, combined dexmedetomidine fentanyl rat administered by intraperitoneal route. A total 40 Sprague Dawley...
Summary Reasons for performing study: Lidocaine and ketamine are administered to horses as a constant rate infusion (CRI) during inhalation anaesthesia reduce anaesthetic requirements. Morphine decreases the minimum alveolar concentration (MAC) in some domestic animals; when CRI horses, morphine does not promote haemodynamic ventilatory changes exerts positive effect on recovery. Isoflurane‐sparing of lidocaine, coadministration has been evaluated small animals but horses. Objectives: To...
Alfaxalone is a neurosteroid with anaesthetic effects and it has been used successfully in several animal species. However, there are no data, to our knowledge, about its efficacy safety ferrets ( Mustela putorius furo). We evaluated variety of regimens ferrets, namely, alfaxalone at 20, 10 5 mg/kg n = 1, 9, respectively; intravenously); medetomidine 20 µg/kg 3; intramuscularly); (20 µg/kg, intramuscularly) plus (2.5 mg/kg, intravenously; 7); tramadol (5 2). Two animals treated respectively,...
Abstract Background: Opioid antagonists at ultra-low doses have been used with opioid agonists to prevent or limit tolerance. The aim of this study was evaluate whether an dose naloxone combined remifentanil could block opioid-induced hyperalgesia and tolerance under sevoflurane anesthesia in rats. Methods: Male adult Wistar rats were allocated into one four treatment groups (n = 7), receiving (4 µg·kg−1·min−1) (0.17 ng·kg−1·min−1), alone, saline. Animals evaluated for mechanical nociceptive...
Used since the 1970s as an avian anesthetic, neurosteroid alfaxalone has been reformulated to avoid side effects from its castor oil excipient. This case report describes clinical use of a new formulation (Alfaxan) intravenous anesthetic induction agent in wild isoflurane-anesthetized rose flamingos (Phoenicopterus roseus). Twenty-five male and female underwent orthopedic surgery using isoflurane anesthesia. The animals were induced following one two protocols: inhaled by facemask (ISO; n =...
This study aimed to estimate the reduction in minimum alveolar concentration (MAC) of sevoflurane induced by low and high doses methadone (5 10 mg/kg), tramadol (25 50 butorphanol mg/kg) or morphine rat. A control group received normal saline. Sixty-three adult male Sprague-Dawley rats were anaesthetized with ( n = 7 per group). Sevoflurane MAC was then determined before after intraperitoneal administration opioids The duration basic cardiovascular respiratory measurements also recorded....
Ultralow doses of naloxone, an opioid and toll-like receptor 4 antagonist, blocked remifentanil-induced hyperalgesia the associated increase in minimum alveolar concentration (MAC), but not tolerance. The aim was to determine effects ibudilast, on MAC rat how it might prevent remifentanil.Male Wistar rats were randomly allocated 5 treatment groups (n = 7 per group): 10 mg/kg ibudilast intraperitoneally, 240 µg/kg/h remifentanil IV, plus remifentanil, naloxone or saline. sevoflurane...
Background Acute opioid tolerance is a known entity leading to reduced analgesic efficacy of these drugs in the postoperative period. However, development acute very short term, i.e., during intraoperative period when opioids are being administered, has not been reported. Therefore, aim this study was determine if could develop and limit opioid-induced reduction minimum alveolar concentration (MAC) for inhalant anesthetics. Methods Male Wistar rats were randomly allocated receive two doses...
Recruitment manoeuvres aim at reversing atelectasis during general anaesthesia but are associated with potential risks such as barotrauma.To explore the range of pressures that can be used safely to fully recruit lung without causing barotrauma in an ex-vivo healthy rabbit model.Prospective, randomised, experimental study.Experimental Unit, La Paz University Hospital, Madrid, Spain.Fourteen young New Zealand rabbits 12 weeks age.Animals were euthanised, thorax and both pleural spaces opened...
Preoperative analgesics are being increasingly used to provide analgesia in the intraoperative and postoperative period. Opioids reduce anaesthetic requirements, although effect varies with different drug species. The aim of this work was determine whether buprenorphine reduces minimum alveolar concentration (MAC) isoflurane a dose-related fashion, is similar morphine when clinical doses both drugs rat. Thirty-six male Wistar rats were anaesthetized isoflurane, MAC determined before after...