A5035619186- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Autism Spectrum Disorder Research
- Language Development and Disorders
- Child and Animal Learning Development
- Neural dynamics and brain function
- Infant Health and Development
- Genomic variations and chromosomal abnormalities
- Memory and Neural Mechanisms
- Epilepsy research and treatment
- Neonatal and fetal brain pathology
- Genomics and Rare Diseases
- Effects of Vibration on Health
- Scoliosis diagnosis and treatment
- EEG and Brain-Computer Interfaces
- Neuroscience and Music Perception
- Sleep and related disorders
- Neuroscience and Neuropharmacology Research
- Tactile and Sensory Interactions
- Stress Responses and Cortisol
- Balance, Gait, and Falls Prevention
- Motor Control and Adaptation
- Hearing Loss and Rehabilitation
- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
Université de Montréal
2012-2025
Centre Hospitalier Universitaire Sainte-Justine
2012-2025
Cégep Marie-Victorin
2025
Central Institute of Mental Health
2011-2012
Fragile X Syndrome (FXS) is the most common monogenic form of intellectual disability and one few known causes autism. It caused by a trinucleotide repeat expansion in FMR1 ('Fragile Mental Retardation 1') gene, which prevents expression 'Fragile Protein' (FMRP). In FXS, absence FMRP leads to altered structural functional development synapse, while preventing activity-based synapse maturation synaptic pruning, are essential for normal brain cognitive development. Possible impairments...
Abstract Quantifying cognitive potential relies on psychometric measures that do not directly reflect cortical activity. While the relationship between ability and resting state EEG signal dynamics has been extensively studied in children with below-average performances, there remains a paucity of research focusing individuals normal to above-average functioning. This study aimed elucidate aged four 12 years across potential. Our findings indicate complexity, as measured by Multiscale...
<title>Abstract</title> Snijders Blok-Campeau syndrome (SNIBCPS), a neurodevelopmental disorder first described in 2018, is caused by heterozygous pathogenic variants CHD3. Its encoded protein plays crucial role the development of nervous system embryos. While phenotypic traits have been broadly defined (i.e. global delays such as intellectual disabilities and delayed speech acquisition, physical features characteristic facial macrocephaly), spectrum has not further assessed. We present...
<title>Abstract</title> <bold>Background. </bold>Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders defined by stereotyped behavior and challenges in social communication interaction. ASD associated with various comorbidities, including anxiety, gastrointestinal (GI) symptoms sleep disorders. Evidence supports an association between intestinal dysbiosis the severity ASD-related symptoms. Probiotic intake was suggested to restore microbial homeostasis decrease...
Abstract Research has shown that many copy number variations (CNVs) increase the risk of neurodevelopmental disorders (e.g., autism, ADHD, schizophrenia). However, little is known about effects CNVs on brain development and function. Resting-state electroencephalography (EEG) a suitable method to study disturbances neuronal functioning in CNVs. We aimed determine whether there are resting-state EEG signatures characteristic children with pathogenic activity 109 CNV carriers (66 deletion...
This study investigated the impact of auditory and visual deprivation on speech processing by analyzing evoked potentials (MMN, P3a, P2, N2b) in congenitally blind individuals, cochlear implant (CI) users, normal-hearing controls. Using a passive oddball paradigm with /u/ as standard stimulus /i/ /y/ deviants, we recorded analyzed fronto-central centro-parietal regions. Blind participants exhibited significantly faster MMN N2b latencies than controls CI reflecting enhanced temporal...
Fragile X Syndrome (FXS) is the most common form of X-linked intellectual disability, associated with a wide range cognitive and behavioural impairments. FXS caused by trinucleotide repeat expansion in FMR1 gene located on X-chromosome. expected to prevent expression "fragile mental retardation protein (FMRP)", which results altered structural functional development synapse, including loss synaptic plasticity. This review aims unveil contribution electrophysiological signal studies for...
Fragile X syndrome (FXS) is a neurodevelopmental genetic disorder causing cognitive and behavioural deficits. Repetition suppression (RS), learning phenomenon in which stimulus repetitions result diminished brain activity, has been found to be impaired FXS. Alterations RS have associated with problems FXS; however, relations between intellectual functioning not yet elucidated. EEG was recorded 14 FXS participants 25 neurotypical controls during an auditory habituation paradigm using...
Fragile X Syndrome (FXS) is a neurodevelopmental genetic disorder associated with cognitive and behavioural deficits. In particular, neuronal habituation processes have been shown to be altered in FXS patients. Yet, while such deficits primarily explored using auditory stimuli, less known the visual modality. Here, we investigated putative alteration of repetition suppression faces patients compared controls that had same age distribution. Electroencephalographic (EEG) signals were acquired...
Introduction: Fragile X syndrome (FXS) is a genetic disorder caused by mutation of the fragile mental retardation 1 gene ( FMR1 ). FXS associated with neurophysiological abnormalities, including cortical hyperexcitability. Alterations in electroencephalogram (EEG) resting-state power spectral density (PSD) are well-defined and were found to be linked neurodevelopmental delays. Whether non-linear dynamics brain signal also altered remains studied. Methods: In this study, EEG power, alpha peak...
Neurofibromatosis type 1 (NF1) is a genetic disorder often associated with cognitive dysfunctions, including high occurrence of deficits in visuoperceptual skills. The neural underpinnings these are not fully understood. We used steady-state visual evoked potentials (SSVEPs) to investigate possible alterations the synchronization activity occipital cortex children NF1. SSVEPs were measured using electroencephalography and compared between NF1 (n = 28) neurotypical controls aged 4 13 years...
For newborns and neonates, ultrasound (US) is the most common imaging modality used for examinations due to its accessibility ease of use. However, precise volume measurements remain limited in 2D, while MRI typically avoided because immobilization issues which may require sedation. The objective this study assess validate lateral ventricular total brain volumes obtained with an automatic segmentation method using cerebral trans-fontanelle 3D US. Infants aged between 2 8.5 months old were...
Abstract Neurodevelopmental disorders (NDDs) are mostly diagnosed around the age of 4–5 years, which is too late considering that brain most susceptive to interventions during first two years life. Currently, diagnosis NDDs based on observed behaviors and symptoms, but identification objective biomarkers would allow for earlier screening. In this longitudinal study, we investigated relationship between repetition change detection responses measured using an EEG oddball task year life at age,...
Repetition effects and change detection response have been proposed as neuro-electrophysiological correlates of fundamental learning processes. As such, they could be a good predictor brain maturation cognitive development. We recorded high density EEG in 71 healthy infants (32 females) aged between 3 9 months, while listened to vowel sequences (standard /a/a/a/i/ [80%] deviant /a/a/a/a/ [20%]). Adaptive skills, surrogate development, were measured via the parent form Behavior Assessment...