A5002253010- Venous Thromboembolism Diagnosis and Management
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Poisoning and overdose treatments
- Olfactory and Sensory Function Studies
- Opioid Use Disorder Treatment
- Ion Channels and Receptors
- Heparin-Induced Thrombocytopenia and Thrombosis
- Oral microbiology and periodontitis research
- Anesthesia and Sedative Agents
- Biochemical Analysis and Sensing Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Management and Opioid Use
- Essential Oils and Antimicrobial Activity
- Corneal Surgery and Treatments
- Anesthesia and Pain Management
- Potassium and Related Disorders
- Dental Health and Care Utilization
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Corneal surgery and disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Diabetic Foot Ulcer Assessment and Management
- Intensive Care Unit Cognitive Disorders
- Antibiotics Pharmacokinetics and Efficacy
UMass Memorial Medical Center
2016-2024
Memorial Medical Center
2024
Virginia Commonwealth University
2024
UMass Memorial Health Care
2016-2022
University of Connecticut
2011-2015
Columbia University Irving Medical Center
2014
Menthol, the cooling agent in peppermint, is added to almost all commercially available cigarettes. Menthol stimulates olfactory sensations, and interacts with transient receptor potential melastatin 8 (TRPM8) ion channels cold-sensitive sensory neurons, ankyrin 1 (TRPA1), an irritant-sensing channel. It highly controversial whether menthol cigarette smoke exerts pharmacological actions affecting smoking behavior. Using plethysmography, we investigated effects of on respiratory irritation...
Addition of menthol to cigarettes may be associated with increased initiation smoking. The potential mechanisms underlying this association are not known. Menthol, likely due its effects on cold-sensing peripheral sensory neurons, is known inhibit the sensation irritation elicited by respiratory irritants. However, it remains unclear whether modulates cigarette smoke irritancy and nicotine absorption during initial exposures cigarettes, thereby facilitating smoking initiation. Using...
Objective: To report 3 cases in which doses of bivalirudin higher than commonly used clinical practice were required order to achieve therapeutic anticoagulation as monitored by the activated partial thromboplastin time (aPTT). Case Summary: The medical records patients who large remain thoroughly reviewed. In all patients, was initiated at a rate appropriate for patients' renal function and titrated using nurse-driven protocol with recommended dose adjustments based on aPTT. Indications...
Enoxaparin is standard of care for venous thromboembolism (VTE) prophylaxis in adult trauma patients, but fixed-dose protocols are suboptimal. Dosing based on body mass index (BMI) or total weight (TBW) improves target prophylactic anti-Xa level attainment and reduces VTE rates. A novel strategy using estimated blood volume (EBV) may be more effective results a single-center study. This study compared BMI-, TBW-, EBV-based, hybrid enoxaparin dosing strategies at achieving anti-Factor Xa...
Maintaining dental implants and managing peri-implant tissues has become integral to practice. Owing the larger number of placed, lesions is increasing. Periodontal implant maintenance therapy (PIMT) provides a conservative long-term treatment modality monitor maintain implants. This study aims investigate periodontal effects on tissue health add existing evidence. A retrospective analysis included patients with 1-7 years follow-up, assessing peri-implantitis early failure as outcome...
Purpose Previous studies analyzing neuromuscular blocking agents (NMBAs) in acute respiratory distress syndrome (ARDS) have evaluated the benefit of cisatracurium with conflicting results, and data evaluating other NMBAs remains limited. The objective this study was to compare efficacy safety vecuronium ARDS. Materials methods A single-center, retrospective, propensity matched review patients who received or continuous infusions between October 1, 2017 June 30, 2020 for ARDS conducted....
Langenstroer, Elizabeth; Herrmann, David; Carver, Thomas; Gibson, Gabrielle; Ha, Michael; Alexander, Kaitlin; Maynard, Kaylee; Bamberg, Kristen; Chanas, Tyler; Denny, Kailey; O'Keefe, Mary; O'Brien, Marisa; Gonzalez, Mariela Cardona; Rein, Lisa; Chui, Sai Ho; Hobbs, Brandon; Pajoumand, Mehrnaz; Peppard, William Author Information
Copyright © 2016 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
Introduction: Buprenorphine is a partial mu-opioid receptor agonist with high affinity to its receptor, which raises concerns of blocking or displacing full opioid agonists when used during the perioperative period surgical patients. However, buprenorphine itself has analgesic potency. Discontinuing may lead suboptimal pain control and increase risk for use disorder (OUD) relapse. There limited data continuation perioperatively. Methods: This study retrospective cohort adult patients taking...
1Department of Pharmacy, UMass Memorial Medical Center, Worcester, MA 2Department Trauma Surgery,
Introduction: Trauma patients are at an elevated risk for venous thromboembolism (VTE) and the optimal dosing strategy of enoxaparin VTE prophylaxis is unclear. Our institution previously used a peak anti-Xa level guided protocol in trauma patients, but this was changed to trough April 2020. This study aims determine efficacy safety versus patients. Methods: retrospective, observational pre-post included adult admitted ICU or acute care floor >48 hours who received ≥3 consecutive doses....
Critical Care Medicine: January 2022 - Volume 50 Issue 1 p 718 doi: 10.1097/01.ccm.0000812048.87123.cf
Critical Care Medicine: January 2022 - Volume 50 Issue 1 p 461 doi: 10.1097/01.ccm.0000810036.31911.63