A5100718098- Fluorine in Organic Chemistry
- Synthesis of Organic Compounds
- Natural product bioactivities and synthesis
- Cyclopropane Reaction Mechanisms
- Synthesis and biological activity
- Inorganic Fluorides and Related Compounds
- Flavonoids in Medical Research
- Biological Activity of Diterpenoids and Biflavonoids
- Oxidative Organic Chemistry Reactions
- Phytoestrogen effects and research
- Synthesis and Reactions of Organic Compounds
- Asymmetric Synthesis and Catalysis
- Click Chemistry and Applications
- Molecular Sensors and Ion Detection
- Chromatography in Natural Products
- Carbohydrate Chemistry and Synthesis
- Catalytic Cross-Coupling Reactions
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Analysis
- Bioactive natural compounds
- Phytochemistry and Bioactive Compounds
- Phytochemistry and Biological Activities
- Sulfur Compounds in Biology
- Luminescence and Fluorescent Materials
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
Minzu University of China
2025
Macao Polytechnic University
2023-2025
Changzhou University
2023-2025
University of South China
2015-2024
Fudan University Shanghai Cancer Center
2024
Shanghai Institute of Nutrition and Health
2024
Shanghai Institutes for Biological Sciences
2024
Hohai University
2024
Hunan Vocational Institute of Technology
2023-2024
Hunan Institute of Technology
2024
Cross-coupling between difluorocarbene and carbene-derived intermediates generated from diazocompounds was developed to give gem-difluoroolefins, which constitutes a fast practical pathway achieve hindered gem-difluoroolefins. The cross-coupling aryl diazoacetates proceeded smoothly in the presence of copper source, whereas its coupling with diaryl diazomethanes occurred well under metal-free conditions. A mechanism involving copper–difluorocarbene complex proposed.
Abstract The decarboxylation of potassium 2‐pyridinyl sulfonyldifluoroacetate and its subsequent reaction with aldehydes was found to be an efficient approach for the Julia–Kocienski under mild conditions give gem ‐difluoro olefins in moderate excellent yields. Owing high stability pure state easy polar solvents, is expected ‐difluoro‐olefination reagent.
A series of chrysin benzimidazole derivatives were synthesised and evaluated for their anticancer activity in the search potential agents. Among them, compound 18 displayed most potent anti-proliferative against MFC cells with IC50 values 25.72 ± 3.95 μM. The flow cytometry results that induced apoptosis a dose-dependent manner caused cell cycle to be arrested G0/G1 phase. Furthermore, preliminary vivo was also studied tumour-bearing mice, exerted good inhibition effect on tumour growth....
A nickel-catalyzed tandem reaction of <italic>N</italic>-vinylamides with arylboronic acids and bromodifluoroacetate has been developed. The efficiently furnishes a series protected α,α-difluoro-γ-amino acid esters.
Pincer and related metal complexes containing tunable tridentate ligand frameworks display promising antitumor activity.
Described herein is an efficient visible light mediated trifluoromethylation of (hetero)arenes using TFSP as a CF 3 source. Various aromatic (hetero)cycles could undergo this protocol to give the corresponding products.
Volumetric muscle loss (VML) results in the impediment of skeletal function. Tissue engineering scaffolds have been widely developed and used regeneration. However, scaffold implantation causes an immune response that endogenously regulates implant integration tissue Moreover, vascularization is thought to be a principal obstacle reconstruction defects. Thus, creating pro-regenerative microenvironment facilitates regeneration supports angiogenesis represents promising strategy for repair...
In the wake of accelerated advancement Internet Things(IoT) technology, a significant volume multimedia information is emerging as dominant component IoT applications. However, this also led to big security risks. Therefore, secure and reliable image encryption scheme based on non-degenerate hyper chaos dynamic bidirectional permutation proposed for characteristic digital images which primary carrier in communication environment. The uses discrete generate pseudo-random sequences applies...
Metabolic dysregulation is prominent in triple-negative breast cancer (TNBC), yet therapeutic strategies targeting metabolism are limited. Here, utilizing multiomics data from our TNBC cohort (n = 465), we demonstrated widespread splicing deregulation and increased spliceosome abundance the glycolytic subtype. We identified SNRNP200 as a crucial mediator of glucose-driven metabolic reprogramming. Mechanistically, glucose induces acetylation at K1610, preventing its proteasomal degradation....
Abstract This review describes the research progress of N ‐formylsaccharin as a newly efficient and environmentally friendly carbon monoxide (CO) surrogate in carbonylation reactions including synthesis aldehydes, esters, ketones, acyl fluorides or other reactions. Besides, its advantages term inexpensive, ease handling stable on storage significantly enhance practicality approach laboratory scale.
A series of trifluoromethylated aurone derivatives were synthesized, and the structure 6‐hydroxy‐4‐trifluoromethylated was determined by single crystal X‐ray analysis. Their anticancer activities against leucocythemia (HL‐60) colorectal adenocarcinoma (HT‐29) evaluated standard MTT method in vitro with 5‐fluorouracil as a positive contrast drug. The results showed that all ( Z )‐trifluoromethylated had potential activities.
Bromotrifluoromethane (CF3Br) is a simple, inexpensive and abundant industrial material employed as trifluoromethylating reagent. However, only limited strategies using CF3Br fluorine source are reported. Herein, we describe visible-light-induced hydrotrifluoromethylation of alkenes alkynes with CF3Br. The reaction proceeds under mild conditions good functional group tolerance, providing new route for the application BrCF3 in organic synthesis.
A near-infrared (NIR) “off–on” fluorescent probe was developed for the detection of H<sub>2</sub>S. The new possesses a highly selective and sensitive response to has low toxicity successfully used detect H<sub>2</sub>S in biological serum samples living cells.