A5047585736- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Orthopedic Surgery and Rehabilitation
- Total Knee Arthroplasty Outcomes
- Sarcoma Diagnosis and Treatment
- Elbow and Forearm Trauma Treatment
- Bone Tumor Diagnosis and Treatments
- Organ and Tissue Transplantation Research
- Bacterial Identification and Susceptibility Testing
- Blood transfusion and management
- Dental Implant Techniques and Outcomes
- Cardiac tumors and thrombi
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Infective Endocarditis Diagnosis and Management
- Shoulder Injury and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Medical Malpractice and Liability Issues
- Dental Trauma and Treatments
- Bone fractures and treatments
- Transplantation: Methods and Outcomes
- Surgical site infection prevention
- Anatomy and Medical Technology
- T-cell and B-cell Immunology
- Spine and Intervertebral Disc Pathology
Haga Hospital
2015-2022
Reinier de Graaf Hospital
2002-2005
Leiden University Medical Center
1999-2005
Leiden University
1997
We analysed the bacterial contamination of 1999 bone allografts retrieved from 200 cadaver donors under sterile operating conditions. The effect various factors on relative risk was estimated using a multiple logistic regression model. Organisms low pathogenicity were cultured 50% grafts and high 3%. with pathogenic organisms (mainly skin commensals) increased by factor 1.6 for each member added to procurement team. contaminants gastrointestinal tract) 3.4 times higher in traumatic cause...
In suspected scaphoid fractures with normal initial radiographs, the usual care is casting, but only 10% of patients have fractures. To reduce overtreatment, we evaluated whether bandaging, instead resulted in noninferior functional outcomes. We included adults and radiographs at emergency department our multicenter randomized controlled trial. Patients were to 3-day bandaging or 2-week casting. Questionnaires, physical examination, performed 2 weeks 1 year. Additional questionnaires sent...
Epidiaphyseal intercalary reconstruction has become possible for bone tumors that extend into the epiphysis because advances in magnetic resonance imaging and chemotherapy allow close resection while sparing juxtaarticular joint. In a retrospective study, we questioned whether epidiaphyseal reconstructions around knee had clinical outcome (measured as long-term survival, complication rate, functional score) comparable with metadiaphyseal diaphyseal reconstructions. Between 1988 1999, 14...
We analysed the bacterial contamination of 1999 bone allografts retrieved from 200 cadaver donors under sterile operating conditions. The effect various factors on relative risk was estimated using a multiple logistic regression model. Organisms low pathogenicity were cultured 50% grafts and high 3%. with pathogenic organisms (mainly skin commensals) increased by factor 1.6 for each member added to procurement team. contaminants gastrointestinal tract) 3.4 times higher in traumatic cause...
Low-grade surface tumours of bone may theoretically be treated by hemicortical resection, retaining part the circumference cortex. An inlay allograft used to reconstruct defect. Since 1988 we have performed 22 procedures in selected patients with low-grade parosteal osteosarcoma (6), peripheral chondrosarcoma (6) and adamantinoma (10). Restricted medullary involvement was not a contraindication for this procedure. There no evidence local recurrence or distant metastasis at mean follow-up 64...
We analyzed factors influencing the contamination rate of allografts and blood samples obtained from postmortem bone donors. 5,710 were harvested, 550 donors which 3,164 (55%) swab culture negative. Blood cultures positive in 140 (26%). The risk graft increased with each extra team member (Odds Ratio 1.9). It was also higher organisms greater virulence a (OR 3.5). per hour 1.1) same increase seen high virulence. In multiple trauma, 8.2), but smaller preceding organ procurement 0.1). To...
We analyzed factors influencing the contamination rate of allografts and blood samples obtained from postmortem bone donors. 5,710 were harvested, 550 donors which 3,164 (55%) swab culture negative. Blood cultures positive in 140 (26%). The risk graft increased with each extra team member (Odds Ratio 1.9). It was also higher organisms greater virulence a (OR 3.5).The per hour 1.1) same increase seen high virulence. In multiple trauma, 8.2), but smaller preceding organ procurement 0.1). To...
Low-grade surface tumours of bone may theoretically be treated by hemicortical resection, retaining part the circumference cortex. An inlay allograft used to reconstruct defect. Since 1988 we have performed 22 procedures in selected patients with low-grade parosteal osteosarcoma (6), peripheral chondrosarcoma (6) and adamantinoma (10). Restricted medullary involvement was not a contraindication for this procedure. There no evidence local recurrence or distant metastasis at mean follow-up 64...
Periprosthetic joint infection (PJI) is a devastating complication following total hip replacement. The direct anterior approach for replacement becoming increasingly popular. However, little known about the success rate of treatment with debridement, antibiotics, and implant retention (DAIR) using approach. aim this study was to analyze effectiveness DAIR identify patient surgical factors that influence results.Seventy-four patients (75 hips) in whom had been performed were identified from...
Abstract Background Isolated trapezium fractures are rare and account for only 1 to 5% of all carpal but still the third most common fracture. Trapezium hard detect easily missed on standard radiographs. can be treated conservatively, as well operatively, best treatment is debatable. Damage joint surface between base first metacarpal or scaphoid could cause pain restriction movements. Therefore, it important diagnose treat fracture at early stage, so that articular congruence guaranteed....
The primary aim of this clinical and radiostereometric study was to the migration pattern surface replacement trapeziometacarpal joint prosthesis (SRTMTMC, Avanta®, San Diego, CA). secondary aims were assess patient-related outcomes survival 5 years after surgery. Ten patients received prosthesis. Radiostereometric radiographs obtained 6 weeks, months, 1 year post-operatively analysed using model-based software. All completed DASH Nelson Hospital scores at these follow-ups. Mean translations...
We analysed the cellular immune response in ten transplantations of different massive bone allografts, which five had a poor clinical outcome. Cytotoxic T lymphocytes (CTL) and helper (TH) against mismatched donor antigens were found all patients. More importantly, CTL with high affinity for cases. High-affinity need no CD8 molecule to stabilise antigen binding are strongly associated rejection heart corneal transplants. Even after removal most bone-marrow cells, we high-affinity TH...
We analysed the cellular immune response in ten transplantations of different massive bone allografts, which five had a poor clinical outcome. Cytotoxic T lymphocytes (CTL) and helper (TH) against mismatched donor antigens were found all patients. More importantly, CTL with high affinity for cases. High-affinity need no CD8 molecule to stabilise antigen binding are strongly associated rejection heart corneal transplants. Even after removal most bone-marrow cells, we high-affinity TH...
Background and purpose — Proton-pump inhibitors (PPI) have previously been associated with an increased risk of infections such as community-acquired pneumonia, gastrointestinal central nervous system infection. Therefore, we evaluated a possible association between proton-pump inhibitor use prosthetic joint infection (PJI) in patients total hip arthroplasty (THA), because they can be stopped perioperatively or switched to less harmful alternative. Patients methods A cohort 5,512 primary...
The purpose of this study was to determine the feasibility Roentgen Stereophotogrammetric Analysis (RSA) in total joint arthroplasty trapeziometacarpal (TMC) thumb.In five cadaveric hands TMC-joint replaced by Surface Replacement Trapeziometacarpal prosthesis (SR™ TMC prosthesis; Avanta, San Diego, CA) and tantalum beads 0.8 mm were implanted for RSA. RSA radiographs two directions made ten positions calculate measurement error. Migration values from zero are indicative number detected...
The perioperative use of certain medication may influence the risk developing a periprosthetic joint infection (PJI). Inhaled corticosteroids (ICSs) and cardiovascular drugs are widely used against pulmonary diseases. While oral anticoagulants have been shown to increase PJI, this is not clear for ICSs. In contrast, some drugs, such as amlodipine, nifedipine statins, documented show an antimicrobial effect, suggesting synergistic effect with antibiotics in treatment (multi-resistant)...