A5059371770- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Urticaria and Related Conditions
- Immune Response and Inflammation
- Macrophage Migration Inhibitory Factor
- GDF15 and Related Biomarkers
- Pediatric health and respiratory diseases
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory mediators and NSAID effects
- Cytokine Signaling Pathways and Interactions
- Axon Guidance and Neuronal Signaling
- Influenza Virus Research Studies
- Food Allergy and Anaphylaxis Research
- Immunodeficiency and Autoimmune Disorders
- Angiogenesis and VEGF in Cancer
- Inhalation and Respiratory Drug Delivery
- Parasites and Host Interactions
- Blood groups and transfusion
- Herpesvirus Infections and Treatments
- Eosinophilic Esophagitis
- Respiratory and Cough-Related Research
McGill University Health Centre
2012-2021
Montreal Children's Hospital
2021
Boston Children's Hospital
2016-2021
Harvard University Press
2020
Harvard University
2014-2019
Université de Montréal
2011-2017
Boston Children's Museum
2015
McGill University
2010-2014
Christie (Canada)
2009-2014
Boston University
2014
Aspirin gained tremendous popularity during the 1918 Spanish Influenza virus pandemic, 50 years prior to demonstration of their inhibitory action on prostaglandins. Here, we show that influenza A (IAV) infection, prostaglandin E2 (PGE2) was upregulated, which led inhibition type I interferon (IFN) production and apoptosis in macrophages, thereby causing an increase replication. This role PGE2 not limited innate immunity, because both antigen presentation T cell mediated immunity were also...
Allergic diseases are chronic inflammatory disorders in which there is failure to mount effective tolerogenic immune responses inciting allergens. The alarming rise the prevalence of allergic recent decades has spurred investigations elucidate mechanisms breakdown tolerance these and means restoring it. Tolerance allergens critically dependent on generation allergen-specific regulatory T (Treg) cells, mediate a state sustained non-responsiveness offending allergen. In this review, we...
Tregitopes (T regulatory epitopes) are IgG-derived peptides with high affinity to major histocompatibility complex class II (MHCII), that known promote tolerance by activating T cell (Treg) activity. Here we characterized the effect of IgG in a well-established murine model allergic asthma, demonstrating vivo antigen-specific via adoptive transfer Tregitope-and-allergen-activated Tregs. Asthma is heterogeneous chronic inflammatory condition affecting airways and impacting over 300 million...
Summary Background Intravenous immunoglobulin (IVIG) has potent anti‐inflammatory and immune‐modulating properties. IVIG been utilized as a steroid‐sparing agent in severe asthma, but the results of clinical trials have conflicting. Objective To determine whether is able to attenuate bronchial reactivity, pulmonary inflammation T cell function using murine model allergic airways disease. Methods BALB/c or C57BL/6 mice were sensitized ovalbumin (OVA) phosphate‐buffered saline control local...
The regulatory properties of B cells have been studied in autoimmune diseases; however, their role allergic diseases is poorly understood. We demonstrate that Semaphorin 4C (Sema4C), an axonal guidance molecule, plays a crucial cell function. Mice deficient Sema4C exhibited increased airway inflammation after allergen exposure, with massive eosinophilic lung infiltrates and Th2 cytokines. This phenotype was reproduced by mixed bone marrow chimeric mice only cells, indicating lymphocytes were...
Abstract IVIg is widely used as an immunomodulatory therapy. We have recently demonstrated that protects against airway hyperresponsiveness (AHR) and inflammation in mouse models of allergic airways disease (AAD), associated with induction Foxp3+ regulatory T cells (Treg). Using mice carrying a DTR/EGFP transgene under the control Foxp3 promoter (DEREG mice), we demonstrate this study generates de novo population peripheral Treg (pTreg) absence endogenous Treg. IVIg-generated pTreg were...
Lymphocyte subpopulations ("active' T cells, total and B cells), leukocyte migration, lymphocyte transformation, complements (CH50, C3, C4), immune complexes in serum cerebrospinal fluid were studied 23 patients with subacute sclerosing panencephalitis. The percentage of active cells was normal. number positive migration inhibitory response to phytoyhemagglutinin lower than controls, corresponding the diminished patients. C1q binding (immune complex formation) found sera 10
The Interleukin-4 receptor alpha chain variant R576 (IL-4Ra-R576) is associated with severe asthma characterized by a mixed TH2-TH17 response. Past research demonstrated that treatment of Il4raR576 mice anti-IL-6 antibody protected against airway inflammation. We analyzed the response two patients persistent IL4RR576allelic treated tocilizumab. Patient 1: 6-year-old persistent, non-atopic homozygous IL4RR576 variant. He had ongoing exacerbations despite ICS/LABA, montelukast, prednisolone,...
Abstract We have shown that induced regulatory T cells (iTreg) are necessary and sufficient to rescue antigen-challenged mice in a murine model of allergic airways disease (AAD). Intravenous immunoglobulin (IVIg) treatment wild-type sensitized challenged antigen induces Treg dendritic-cell (DC) dependent mechanism. In the present study, DEREG (which co-express diphtheria toxin (DT) receptor with Foxp3, allowing for selective transient depletion Treg) were treated IVIg after all endogenous...