A5063846820- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune cells in cancer
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Multiple Myeloma Research and Treatments
- Cell Adhesion Molecules Research
- Protein Degradation and Inhibitors
- Cytomegalovirus and herpesvirus research
- Chemokine receptors and signaling
- CAR-T cell therapy research
- Reproductive System and Pregnancy
- Mental Health Research Topics
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- Bipolar Disorder and Treatment
- Platelet Disorders and Treatments
- Histone Deacetylase Inhibitors Research
- Treatment of Major Depression
- Cancer Immunotherapy and Biomarkers
- Eosinophilic Esophagitis
- Synthesis and biological activity
- interferon and immune responses
- Endometriosis Research and Treatment
- IL-33, ST2, and ILC Pathways
Istituto Pasteur
2015-2024
Sapienza University of Rome
2015-2024
Università di Camerino
2015
Instituto Pasteur
2013
I.R.C.C.S. Oasi Maria SS
2012
Otto-von-Guericke University Magdeburg
2009
Vita-Salute San Raffaele University
2009
Med-Storm Innovation (Norway)
2009
Scripps Research Institute
2004-2006
University of California, San Diego
2004-2006
Abstract Cancer progression is continuously controlled by the immune system which can identify and destroy nascent tumor cells or inhibit metastatic spreading. However, its deregulated activity in microenvironment also promote favoring outgrowth of cancers capable escaping control, a process termed cancer immunoediting. This process, has been classified into three phases, i.e. “elimination”, “equilibrium” “escape”, influenced several cancer- microenvironment-dependent factors. Senescence...
New arylthioindole derivatives having different cyclic substituents at position 2 of the indole were synthesized as anticancer agents. Several compounds inhibited tubulin polymerization submicromolar concentration and cell growth low nanomolar concentrations. Compounds 18 57 superior to previously 5. Compound was exceptionally potent an inhibitor growth: it showed IC50 = 1.0 nM in MCF-7 cells, uniformly active whole panel cancer cells colchicine combretastatin A-4. 18, 20, 55, notably more...
Exosomes are a class of nanovesicles formed and released through the late endosomal compartment represent an important mode intercellular communication. The ability anticancer chemotherapy to enhance immunogenic potential malignant cells mainly relies on establishment cell death (ICD) release damage-associated molecular patterns (DAMPs). Here, we investigated whether genotoxic stress could promote exosomes from multiple myeloma (MM) studied immunomodulatory properties they exert NK cells,...
Abstract Natural killer (NK) cells are innate cytotoxic lymphocytes that play a key role in cancer immunosurveillance thanks to their ability recognize and kill cells. NKG2D is an activating receptor binds MIC ULBP molecules typically induced on damaged, transformed or infected The release of ligands (NKG2DLs) the extracellular milieu through protease‐mediated cleavage by vesicle (EV) secretion allows evade NKG2D‐mediated immunosurveillance. In this work, we investigated immunomodulatory...
We report on the utility of a new instrument to identify subtypes major depressive episodes with special reference pseudo-unipolar conditions. By incorporating reliable measures and hyperthymic temperamental characteristics in subtype definitions, we achieve sharpest possible demarcation between unipolar bipolar disorders. The procedures also reveal that 1 out 3 primary depressives consecutive series 405 patients belong spectrum. Furthermore, among bipolars, II disorder (redefined as...
Studies with inhibitors have implicated protein kinase C (PKC) in the adhesive functions of integrin αIIbβ3 platelets, but responsible PKC isoforms and mechanisms are unknown. interacts directly tyrosine kinases c-Src Syk. Therefore, we asked whether might also interact PKC. Of several expressed only PKCβ co-immunoprecipitated response to interaction platelets soluble or immobilized fibrinogen. recruitment was accompanied by a 9-fold increase activity immunoprecipitates. RACK1, an...
Genotoxic stress can promote antitumor NK cell responses by upregulating the surface expression of activating ligands on cancer cells. Moreover, a number studies suggested role for soluble group 2D in impairment tumor recognition and killing. We investigated whether genotoxic could release (MHC class I-related chain [MIC]A MICB), as well molecular mechanisms underlying this event human multiple myeloma (MM) Our results show that agents used therapy MM (i.e., doxorubicin melphalan)...
Increasing evidence indicates that cancer cell stress induced by chemotherapeutic agents promote antitumor immune responses and contribute to their full clinical efficacy. In this article, we identify the signaling events underlying chemotherapy-induced NKG2D DNAM-1 ligand expression on multiple myeloma (MM) cells. Our findings indicate sublethal doses of doxorubicin melphalan initiate a DNA damage response (DDR) controlling upregulation MM lines patient-derived malignant plasma cells in...
Although decidual natural killer (NK) cell accumulation and vascular remodeling are critical steps to ensure successful pregnancy, the molecular mechanisms controlling these events poorly defined.Herein we analyzed whether chemerin, a recently identified chemoattractant involved in many pathophysiological processes, could be expressed uterine compartment regulate relevant for good outcome of pregnancy.Chemerin expression human primary culture stromal (ST) cells, extravillous trophoblast...
// Cinzia Fionda 1 , Maria Pia Abruzzese Alessandra Zingoni Francesca Cecere Elisabetta Vulpis Giovanna Peruzzi 2 Soriani Rosa Molfetta Rossella Paolini Rosaria Ricciardi 3 Teresa Petrucci Angela Santoni 1,4,* and Marco Cippitelli 1,* Department of Molecular Medicine, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University Rome, Italy Italiano di Tecnologia, CLNS@Sapienza, Division Hematology, Cellular Biotechnologies 4 Mediterraneo Neuroscienze Neuromed, Pozzilli, * These authors...
Anti-cancer immune responses may contribute to the control of tumors after conventional chemotherapy, and different observations have indicated that chemotherapeutic agents can induce resulting in cancer cell death immune-stimulatory side effects. Increasing experimental clinical evidence highlight importance natural killer (NK) cells toward multiple myeloma (MM), combination therapies able enhance activity NK against MM are showing promise treating this hematologic cancer. The epigenetic...
// Massimo Nabissi 1, * , Maria Beatrice Morelli 2, Offidani 3 Consuelo Amantini 4 Silvia Gentili Alessandra Soriani 2 Claudio Cardinali Pietro Leoni Giorgio Santoni 1 School of Pharmacy, Experimental Medicine Section, University Camerino, Italy Department Molecular Medicine, Sapienza University, Rome, Clinica di Ematologia, Azienda Ospedaliero Universitaria Ospedali Riuniti Ancona, Biosciences and Veterinary These authors have contributed equally to this work Correspondence to: Nabissi,...
Abstract Treatment of multiple myeloma (MM) cells with sublethal doses genotoxic drugs leads to senescence and results in increased NK cell recognition effector functions. Herein, we demonstrated that doxorubicin- melphalan-treated senescent display expression IL15, a cytokine involved activation, proliferation, maturation. IL15 upregulation was evident at the mRNA protein level, both MM lines malignant plasma from patients’ bone marrow (BM) aspirates. However, detectable as soluble only...