A5046678630- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Diet and metabolism studies
- Cancer, Stress, Anesthesia, and Immune Response
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Cancer Genomics and Diagnostics
- Natural Compounds in Disease Treatment
- Cancer Cells and Metastasis
- Organ Transplantation Techniques and Outcomes
- Heat shock proteins research
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Histone Deacetylase Inhibitors Research
- Hedgehog Signaling Pathway Studies
- Acute Myeloid Leukemia Research
- Alcohol Consumption and Health Effects
- Pancreatic function and diabetes
- Immune cells in cancer
- Phagocytosis and Immune Regulation
University of Alabama at Birmingham
2021-2025
University of Pittsburgh Medical Center
2022-2025
University of Miami
2016-2022
Sylvester Comprehensive Cancer Center
2017-2022
O'Neal Comprehensive Cancer Center
2022
Jackson Memorial Hospital
2020
Creative Commons
2020
University of Minnesota
2017
All India Institute of Medical Sciences
2013
Cigarette smoke exposure (CSE) increases the risk for a plethora of cancers. Recent evidence indicates that gut microbiome can influence cancer progression by immune system modulation. Since CSE alters microbiome, we hypothesized serves as causative link between smoking and growth. Through combination syngeneic animal models fecal microbiota transplantation studies, established an essential role smoke-induced dysbiosis in 16s rRNA sequencing liquid chromatography-mass spectrometry indicated...
Introduction: Liver transplantation (LT) provides significant survival benefits to patients with unresectable HCC. In the United States, organ allocation policies for HCCs within Network Organ Sharing criteria do not prioritize based on their differences in oncological characteristics. This study assessed whether transplant-associated (TASBs) vary among different tumor burden scores (TBS) measured at time of listing. Methods: We analyzed data from adults applying HCC MELD exception points...
There is an urgent need for novel and effective treatment options acute myeloid leukemia (AML). Triptolide, a diterpenoid tri-epoxide compound isolated from the herb Tripterygium wilfordii its water-soluble pro-drug-Minnelide have shown promising anti-cancer activity. A recent clinical trial patients with solid tumors confirmed safety efficacy at biologically equivalent doses of 0.2 mg/kg/day lower.Cell viability multiple AML cell lines as well patient apheresis samples were evaluated by...
Despite decades of research, there is no specific therapy for acute pancreatitis (AP). In the current study, we have evaluated efficacy pirfenidone, an antiinflammatory and antifibrotic agent that approved by FDA treatment idiopathic pulmonary fibrosis (IPF), in ameliorating local systemic injury AP. Our results suggest with pirfenidone therapeutic settings (e.g., after initiation injury), even when administered at peak injury, reduces severity inflammation multiple models vitro evaluation...
Purpose: Laparoscopic adrenalectomy is well established for treatment of adrenal lesions. However, bilateral Cushing syndrome a challenging and time-consuming operation. We report our experience laparoscopic this disease in 19 patients. Materials Methods: From September 2009 to August 2012, we have operated patients with performed using the transperitoneal approach; synchronous 15 staged 4 In patients, surgery was carried out sequentially on both sides lateral position intraoperative change...
This study investigates trends in hospitalization and liver transplant rates the US from 2005 to 2021 associated with alcohol-induced disease.
Heat shock protein 70 (Hsp70), a chaperone, is known to promote cell survival and tumor progression. However, its role in the microenvironment (TME) largely unknown. We specifically evaluated Hsp70 TME by implanting tumors wild-type (WT) controls or Hsp70−/- animals, thus creating with without Hsp70. Loss of led significantly smaller tumors; there were no differences stromal markers, but interestingly, depletion CD8 + T-cells abrogated this suppressive effect, indicating that loss affects...
Pancreatic cancer (PDAC) continues to be a dreadful disease with 5-year overall survival surpassing single digits recently [[1]Atlanta G.A. American Cancer SocietyCancer facts and figures 2020. Society, 2020Google Scholar]. With the lack of early diagnosis continued failure treatment options in PDAC, it is imperative that we comprehensively understand its evolving immune landscape, as our system only defence heterogeneous this itself. Although immunotherapy has not worked better...
Abstract The fascinating hypothesis that microbes lead to cancer has long been dwelled upon but only recently investigated in cancers other than those of stomach and colon. Microbes can affect cells directly through toxins or metabolites. They also play a significant role the development maturation immune system indirectly system. Reliable mouse models affordable sequencing technologies, have made it possible current times, delineate undermining surveillance promoting oncogenesis. In this...