A5008023296- Gut microbiota and health
- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- Mast cells and histamine
- Cell death mechanisms and regulation
- IL-33, ST2, and ILC Pathways
- Nerve injury and regeneration
- Natural Compounds in Disease Treatment
- Intestinal Malrotation and Obstruction Disorders
- Congenital Anomalies and Fetal Surgery
- Histiocytic Disorders and Treatments
- Tryptophan and brain disorders
- Vascular Malformations and Hemangiomas
- Immune cells in cancer
- Hematopoietic Stem Cell Transplantation
- Restless Legs Syndrome Research
- Asthma and respiratory diseases
- Cancer Cells and Metastasis
- Polyomavirus and related diseases
- Maternal and fetal healthcare
- Chronic Myeloid Leukemia Treatments
- Vascular Malformations Diagnosis and Treatment
- RNA regulation and disease
- Obstructive Sleep Apnea Research
- Poverty, Education, and Child Welfare
University of Nebraska Medical Center
2022-2025
Sylvester Comprehensive Cancer Center
2019-2025
University of Miami
2019-2025
Pediatrics and Genetics
2025
Mayo Clinic in Arizona
2022-2023
Harlem Hospital Center
2022-2023
Mayo Clinic
2022
Dhaka Medical College and Hospital
2022
Mayo Clinic in Florida
2022
Tilka Manjhi Bhagalpur University
2020
Cigarette smoke exposure (CSE) increases the risk for a plethora of cancers. Recent evidence indicates that gut microbiome can influence cancer progression by immune system modulation. Since CSE alters microbiome, we hypothesized serves as causative link between smoking and growth. Through combination syngeneic animal models fecal microbiota transplantation studies, established an essential role smoke-induced dysbiosis in 16s rRNA sequencing liquid chromatography-mass spectrometry indicated...
Decellularized nerve hydrogels (dNHs) containing bioactive molecules are promising biomaterials for peripheral injury (PNI) treatment and have been extensively applied in clinical preclinical practice. However, most previous research projects studied their influences on nerve-related cellular behaviors two dimensions (2D) without taking hydrogel biomechanics into consideration. The molecular mechanisms underlying the beneficial microenvironment provided by dNHs also remain unclear. In this...
There is an urgent need for novel and effective treatment options acute myeloid leukemia (AML). Triptolide, a diterpenoid tri-epoxide compound isolated from the herb Tripterygium wilfordii its water-soluble pro-drug-Minnelide have shown promising anti-cancer activity. A recent clinical trial patients with solid tumors confirmed safety efficacy at biologically equivalent doses of 0.2 mg/kg/day lower.Cell viability multiple AML cell lines as well patient apheresis samples were evaluated by...
Purpose of review This evaluates the known mechanisms regulating erythroid regeneration via sterile alpha motif protein-14 ( Samd14 ) enhancer, Samd14's role in stem cell factor/Kit and erythropoietin (Epo) signaling, possible SAMD14 functions beyond erythropoiesis, extrapolation to other anemia-response pathways. Recent findings expression is controlled by an anemia-activated E-box-GATA transcriptional enhancer required for regeneration, protein needed acute anemia recovery. interacts with...
Wallenberg's syndrome, also known as posterior inferior cerebellar artery syndrome (lateral medullary syndrome), is to be a common cause of ischemic stroke syndromes in men their 60s and may present with varied symptoms devoid focal neurological signs making it easily missed differential strokes. It involves the vertebral or brainstem. In this case report, we critically examine 66-year-old man newly diagnosed diabetes whose main presentation was dysphagia unsteady gait. There no motor...
A 30-years-old post-cesarean lady presented with a secondary post-partum hemorrhage for aweek, complicated by anemia, which required blood transfusion. Despite conservative medicalmanagement, the bleeding persisted and ultrasonography demonstrated ruptured left uterineartery pseudoaneurysm. Computed Tomography angiogram was performed confirmation andplanning embolization. Transcatheter directed uterine artery pseudoaneurysm embolizationwas performed. Her controlled an uneventful...
Septo-optic dysplasia (SOD) is a rare congenital disorder occurring in only 1 10,000 live births. Initially it was described 1941 by Reeves and further discussed the French-Swiss neurologist de Morsier (1956) as disease addressed his name. SOD combination of triads hypoplasia optic nerve, agenesis midline brain structures, hypothalamic-pituitary axis. The pathophysiology this anomaly yet to be understood, with some hypotheses order establish diagnosis. management modality depends on...
Human herpesvirus 8 (HHV-8) or Kaposi sarcoma is the cause of (KS), most prevalent cancer related to acquired immune deficiency syndrome. About 90% time, KS accompanied by cutaneous lesions; however, systemic illness can develop without involvement. Today's highly active antiretroviral therapy (HAART) era has seen a decrease in prevalence KS. In immunocompromised individuals, it may be challenging differentiate between pneumonia and clinical characteristics pulmonary KS, which might make...
Annular pancreas is an uncommon congenital anomaly which a rare cause of duodenal obstruction. It normally identified during the neonatal period, but may also be in adolescence or adulthood. This diagnosis often overlooked adult patients who present with symptoms suggestive We case AP detected 23-year-old man, complaints continuous vomiting and abdominal discomfort over last 6 months. An upper gastrointestinal study revealed constricted second part duodenum. A computed tomography scan...
Background:Mental health of orphan children is important since they are exposed to additional stressors due lack proper care, separation from family, death parents etc. All these make them more vulnerable psychological disorders like low esteem. Aim this study was assess the self-esteem girls staying in an orphanage home and find out relation age. Materials Methods: The conducted Aurangabad city after taking permission concerned authorities. Cross sectional Study design used. 240 age group 9...
The mammalian cochlea is composed of sensory hair cells as well multiple different types non-sensory supporting cells. Pillar are one type cell that form the tunnel Corti and include two morphologically functionally distinct subtypes: inner pillar (IPCs) outer (OPCs). processes specification differentiation versus still unclear. Here, we show β-Catenin required for establishing IPC identity in cochlea. To differentiate transcriptional adhesion roles identity, examined models deletion;...