A5005516123- Gut microbiota and health
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Clostridium difficile and Clostridium perfringens research
- Biochemical and Molecular Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Mycobacterium research and diagnosis
- Reproductive tract infections research
- Nutrition and Health in Aging
- Preterm Birth and Chorioamnionitis
- Obesity and Health Practices
- Probiotics and Fermented Foods
- Renal Transplantation Outcomes and Treatments
- Hematopoietic Stem Cell Transplantation
- Environmental DNA in Biodiversity Studies
- Indigenous Studies and Ecology
- Dietary Effects on Health
- Ethics in Clinical Research
- Urinary Tract Infections Management
- Oral health in cancer treatment
- Urological Disorders and Treatments
- Tryptophan and brain disorders
University of North Carolina at Charlotte
2021-2025
Approximately 10% of all pregnancies in the United States end preterm birth, and over 14% birth among Black women. Knowledge on associations between vaginal microbiome is important for understanding potential cause assessing risk birth.
Cigarette smoke exposure (CSE) increases the risk for a plethora of cancers. Recent evidence indicates that gut microbiome can influence cancer progression by immune system modulation. Since CSE alters microbiome, we hypothesized serves as causative link between smoking and growth. Through combination syngeneic animal models fecal microbiota transplantation studies, established an essential role smoke-induced dysbiosis in 16s rRNA sequencing liquid chromatography-mass spectrometry indicated...
Abstract The gut microbiota plays an important role in human health and disease. Stool, rectal swab mucosal tissue samples have been used individual studies to survey the microbial community but consequences of using these different sample types are not completely understood. In this study, we report differences stool, communities with shotgun metagenome sequencing 1397 from 240 participants. taxonomic composition stool was distinct, less each other than samples. Functional profile between...
Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ transplant rejection and treat autoimmune diseases. MMF usage, however, limited by severe gastrointestinal toxicity that observed in approximately 45% of recipients. The active form the drug, mycophenolic acid (MPA), undergoes extensive enterohepatic recirculation bacterial β-glucuronidase (GUS) enzymes, which reactivate MPA from mycophenolate glucuronide (MPAG) within tract. GUS enzymes...
Abstract Objective Metabolic and bariatric surgery (MBS) is associated with substantial, but variable, weight outcomes. The gut microbiome may be a factor in determining trajectory, examination has been limited by lack of longitudinal studies robust sequencing. This study aimed to describe changes the associations outcomes more than 2 years post surgery. Methods Data were collected at two Midwestern U.S. centers. Adults undergoing primary MBS assessed before 1, 6, 12, 18, 24 months after BMI...
Metabolic and bariatric surgery (MBS) is the most effective long-term treatment for Class III obesity. Reduced dietary intake considered a behavioral driver of post-surgical weight loss, but limited data have examined this association. Therefore, study prospective, longitudinal relationships between loss over 24 months following Roux-en-Y Gastric Bypass Sleeve Gastrectomy. Relationships were using validated 24-hour recall method. Associations total energy/macronutrient outcomes assessed at...
Metabolic and bariatric surgery (MBS) is the most effective treatment for severe obesity; however, a significant subset of patients does not achieve expected weight loss or have substantial recurrence over time. The intestinal energy harvest potential determinant varying outcomes, but with limited exploration. We assess relationships between diet, harvest, outcomes 24 months in individuals who undergone MBS.
Bacterial resistance to antibiotics is a growing global concern, threatening human and environmental health, particularly among urban populations. Wastewater treatment plants (WWTPs) are thought be “hotspots” for antibiotic dissemination. The conditions of WWTPs, in conjunction with the persistence commonly used antibiotics, may favor selection transfer genes bacterial WWTPs provide an important ecological niche examine spread resistance. We heterotrophic plate count methods identify...
Metabolic and bariatric surgery (MBS) is the most effective long-term treatment for Class III obesity. Reduced dietary intake considered a behavioral driver of post-surgical weight loss, but limited data have examined this association. Therefore, study prospective, longitudinal relationships between loss over 24 months following Roux-en-Y Gastric Bypass Sleeve Gastrectomy. Relationships were using validated 24-h recall method. Associations total energy/macronutrient outcomes assessed at 12-,...
Home-based hematopoietic stem cell transplantation (HCT) is a novel approach that has the potential to improve outcomes, however, impact of transplant location on gut microbiome remains uncharacterized. We hypothesized patients randomized undergo home HCT would have higher taxonomic diversity and lower antimicrobial resistance (AMR) gene abundance compared those undergoing standard hospital HCT.
Abstract Mycophenolate Mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ transplant rejection and treat autoimmune diseases. MMF usage, however, limited by severe gastrointestinal toxicity that observed in approximately 45% of recipients. The active form the drug, mycophenolic acid (MPA), undergoes extensive enterohepatic recirculation bacterial β-glucuronidase (GUS) enzymes, which reactivate MPA from mycophenolate glucuronide (MPAG) within tract. GUS...
Bacterial resistance to antibiotics is a growing global concern, threatening human and environ-mental health, particularly among urban populations. Wastewater treatment plants (WWTPs) are thought be “hotspots” for antibiotic dissemination. The conditions of WWTPs, in conjunction with the persistence commonly used antibiotics, may favor selection trans-fer genes bacterial WWTPs provide an important ecological niche examine spread resistance. We heterotrophic plate count...
Abstract The gut microbiota plays an important role in human health and disease. Stool, swab mucosal tissue samples have been used individual studies to survey the microbial community but consequences of using these different sample types are not completely understood. We previously reported differences composition with 16S rRNA amplicon sequencing between stool, samples. Here, we extended previous study a larger cohort performed shotgun metagenome 1,397 from 240 participants. Consistent...
Abstract Previous studies have investigated the associations between vaginal microbiome and preterm birth (PTB), with aim of determining whether differences in community patterns meaningfully alter risk, could therefore be target intervention. We report on microbial analysis a subset Pregnancy, Infection, Nutrition (PIN) Study, prospectively enrolled cohort women central North Carolina 1995-2001. selected nested case-control this cohort, including 464 White (375 term 89 spontaneous PTB,...