A5008652865- Essential Oils and Antimicrobial Activity
- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Insect Pest Control Strategies
- X-ray Diffraction in Crystallography
- Phytochemicals and Antioxidant Activities
- Thermal and Kinetic Analysis
- Synthesis and Biological Evaluation
- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Analytical Methods in Pharmaceuticals
- Sesquiterpenes and Asteraceae Studies
- Bacterial Identification and Susceptibility Testing
- Phytochemistry Medicinal Plant Applications
- Traditional and Medicinal Uses of Annonaceae
- Allelopathy and phytotoxic interactions
- Mechanical Engineering and Vibrations Research
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Microplastics and Plastic Pollution
- Plant Toxicity and Pharmacological Properties
- Microencapsulation and Drying Processes
- Crystallography and molecular interactions
- Chemical Thermodynamics and Molecular Structure
Universidade Federal do Paraná
2017-2021
Instituto de Pesquisas Jardim Botânico do Rio de Janeiro
2017-2018
Sitagliptin is an inhibitor of the enzyme dipeptidyl peptidase-4, used for treatment type 2 diabetes mellitus. The crystal structure active pharmaceutical solids determines their physical and chemical properties. polymorphism, solvates hydrates can influence free energy, thermodynamic parameters, solubility, solid-state stability, processability dissolution rate, besides directly affecting bioavailability. Thus, physicochemical characterization ingredient required to guarantee rational...
The aim of this study was to evaluate the chemical, antioxidant, and antimicrobial activity essential oils as well anatomy aerial parts from Baccharis aracatubaensis, burchellii, organensis owing therapeutic potential Baccharis. volatile constituents were analyzed using GC/MS, antioxidant evaluated by oxygen radical absorbance capacity (ORACFL ) DPPH assays, a microdilution technique. Of 56 compounds identified, only seven (β-caryophyllene, γ-muurolene, bicyclogermacrene, β-germacrene,...
Background: Orodispersible Tablets (ODTs) are an option to facilitate the intake of pharmaceutical solid dosage forms, which dissolve in mouth within 30 seconds releasing drug immediately with no need for water or chewing. Objective: The main goal our study is technological development lactose-free orodispersible tablets that contain ketoprofen. Methods: We assessed different variables during ODTs: compression techniques conducted after a wet granulation process, aiming optimize flow...
The antimicrobial activities of crude extracts and fractions from three Baccharis L. species were tested against Staphylococcus aureus (ATCC 6538), Escherichia coli 8738), Pseudomonas aeruginosa 9027), Candida albicans 10231) using the microdilution plate method. results showed that extract female B. burchellii Baker had moderate activity S. (minimum inhibitory concentration [MIC], 0.9 mg.mL-1). Among obtained this extract, dichloromethane fraction highest (MIC, 0.4 ethyl acetate 0.6 mg.mL-1...
O mercado de cosméticos destaca-se no Brasil por apresentar crescimento mesmo diante da crise econômica. Devido ao constante aumento na utilização desses produtos é necessário avaliar a segurança microbiológica, especialmente para uso coletivo e, portanto, com maior risco contaminação. objetivo do presente trabalho foi qualidade microbiológica amostras maquiagem, coletivo, cidade Curitiba, Paraná. Foram analisadas quinze (15) coletadas durante o período janeiro agosto 2015. As análises...
Natural products, especially plants, have been investigated as sources of new substances with antimicrobial properties. In this context, the Myrcia genus is extensively researched for presenting such activities. This work aims to evaluate antifungal, antibacterial, and antioxidant properties extracts fractions stems hatschbachii, also characterize two phenolic compounds. The antibacterial antifungal activities were assessed by using broth microdilution method. ethyl acetate fraction (FGA)...
The growing interest in the discovery of new compounds from medicinal plants justifies study phytochemical components these and their biological activities. genus Ocotea exhibits a variety pharmacological, antimicrobial antioxidant effects. aim present was to evaluate potential properties ethyl acetate fraction paranaensis leaves. Isolation identification phenolic also carried out. isolated were characterized by one two-dimensional nuclear magnetic resonance analysis identified as (-)...
The chemical composition of the essential oil obtained from branches Ocotea paranaensis was studied by gas chromatography/mass spectrometry (GC/MS).Twenty-seven compounds, comprising 94.82% total components, were identified.The showed relatively high concentration sesquiterpenes (62.96%), oxygenated (33.33%), and diterpene (3.70%).Regarding major Z-nerolidol (19.16%), germacrene D (12.92%) α-bulnesene (8.47%) could be highlighted, which corresponded to 40.55% substances that found.The has...
Plants have been seen as alternatives for researching natural antimicrobials and herbicides. The aim of this work was to evaluate the antibacterial, antifungal, allelopathic properties leaves extracts Myrcia hatschbachii. crude extract fractions were obtained by Soxhlet apparatus. Antimicrobial activity determined minimum inhibitory concentration (MIC) using broth microdilution method. ethyl acetate fraction showed against Candida albicans (MIC: 62.5 µg/mL), Staphylococcus aureus 500...