A5002977782- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Resistance in Staphylococcus
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Extracellular vesicles in disease
- Sarcoidosis and Beryllium Toxicity Research
- Long-Term Effects of COVID-19
- Streptococcal Infections and Treatments
- Innovations in Medical Education
- Urological Disorders and Treatments
- Milk Quality and Mastitis in Dairy Cows
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pneumocystis jirovecii pneumonia detection and treatment
- IgG4-Related and Inflammatory Diseases
- Head and Neck Surgical Oncology
- Immune responses and vaccinations
- Problem and Project Based Learning
- Pharmaceutical studies and practices
- Sexual Differentiation and Disorders
- Antifungal resistance and susceptibility
- Biochemical and Structural Characterization
- Respiratory viral infections research
- Dermatological diseases and infestations
- Pneumonia and Respiratory Infections
University College London
2021-2024
St George's Hospital
2024
Moorfields Eye Hospital
2024
University of South Alabama
2001-2006
Louisiana State University Health Sciences Center New Orleans
1995
Louisiana State University
1995
Effective control of SARS-CoV-2 infection on primary exposure may reveal correlates protective immunity to future variants, but we lack insights into immune responses before or at the time virus is first detected. We use blood transcriptomics, multiparameter flow cytometry, and T cell receptor (TCR) sequencing spanning incident non-severe in unvaccinated virus-naive individuals identify rapid type 1 interferon (IFN) common other acute respiratory viruses proliferation that discriminate from...
Background Persistent radiological lung abnormalities are evident in many survivors of acute coronavirus disease 2019 (COVID-19). Consolidation and ground glass opacities interpreted to indicate subacute inflammation whereas reticulation is thought reflect fibrosis. We sought identify differences at molecular cellular level, the local immunopathology post-COVID Methods compared single-cell transcriptomic profiles T cell receptor (TCR) repertoires bronchoalveolar cells obtained from...
Purpose This study reports the experience of pediatric preseptal and orbital cellulitis at a London tertiary centre during 6-year period highlights role surgeons in management subperiosteal abscess (SPA).
Abstract The correlates of natural protective immunity to SARS-CoV-2 in the majority who experience asymptomatic infection or non-severe disease are not fully characterised, and remain important as new variants emerge. We addressed this question using blood transcriptomics, multiparameter flow cytometry T cell receptor (TCR) sequencing spanning time incident infection. identified a type 1 interferon (IFN) response common other acute respiratory viruses, proliferation that discriminated from...
A bstract Background Persistent radiological lung abnormalities are evident in many survivors of acute coronavirus disease 2019 (COVID-19). Consolidation and ground glass opacities interpreted to indicate subacute inflammation whereas reticulation is thought reflect fibrosis. We sought identify differences at molecular cellular level, the local immunopathology post-COVID Methods compared single-cell transcriptomic profiles T cell receptor (TCR) repertoires bronchoalveolar cells obtained from...
We report a case of 16-year-old female patient with sickle-cell disease liver abscess secondary to methicillin-resistant Staphylococcus aureus (MRSA). She had initially presented jaundice and abdominal pain subsequently underwent endoscopic retrograde cholangio-pancreaticography followed by laparoscopic cholecystectomy for removal gallstones. However, post-cholecystectomy she generalized computed tomography scan the abdomen revealed abscess. A pigtail catheter was inserted into culture...
Reasons for the spectrum of severity active tuberculosis (TB) disease are incompletely understood. We sought to identify master regulators host immune responses that determine in pulmonary TB. performed molecular profiling human vivo discover associations with extent radiographic TB a patient cohort. then undertook mechanistic studies test causality observed using zebrafish larval Mycobacterium marinum infection model. Transcriptional recall tuberculin skin (TST) challenge, surrogate lung,...
<h3>Background</h3> Steroid 5-alpha-reductase deficiency (5-ARD) is one of the causes male pseudohermaphroditism. It a rare autosomal recessive disorder due to an enzyme responsible for conversion testosterone dihydrotestosterone (DHT). This results in failure full masculinization genitalia. <h3>Case Report</h3> We are reporting case patient who was evaluated our clinic at age 5 months ambiguous Physical exam revealed presence scrotalized labia as well hypertrophic clitoris and palpable...
<h3>Background</h3> Approximately 10% of patients hospitalised with COVID-19 have residual lung abnormalities (RLAs) at 12 months. In clinical practice, CT scan appearances are often used to guide management. Whether such radiological changes reliably reflect immunopathomechanisms, and can therefore inform the treatment approach, is unclear an important question. <h3>Methods</h3> We compared single cell transcriptomic T receptor (TCR) profiles bronchoalveolar lavage cells from Post-COVID...
<h3>Purpose</h3> An interactive, CD-ROM based educational program which allows medical students to perform virtual pediatric rounds has been developed at the University of South Alabama. This contains three-dimensional characters play role hospital staff. Information about clinical cases and disease processes is provided by these characters. In addition signs procedures are presented utilizing multimedia. The provides questions feedback on diagnosis, treatment related procedures. conditions...
<h3>Purpose</h3> To evaluate the rate of nasal carriage methicillin-resistant Staphylococcus aureus (MRSA) in healthy children and to determine staphylococcal chromosomal cassette mec (SCCmec) type toxin profile these isolates. <h3>Methods</h3> Nasal swabs were obtained from 0-18 years old during their well-child visits at University South Alabama outpatient pediatric clinic. All samples collected April 2004. S. was isolated with selective media antibiotic susceptibilities performed...
<h3>Background</h3> Human metapneumovirus (hMPV) is a recently described respiratory pathogen of children. However, there have been no data available regarding the epidemiology and clinical manifestations hMPV infection in our geographical region. <h3>Methods</h3> A prospective cross-sectional evaluation children 0-18 years old presenting to university hospital clinics with symptoms was conducted during months November-April 2004. Following informed consent, parents were interviewed...