A5003845584- Urinary Bladder and Prostate Research
- Neuropeptides and Animal Physiology
- Pelvic floor disorders treatments
- Neuroscience of respiration and sleep
- Pain Mechanisms and Treatments
- Urological Disorders and Treatments
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Sexual function and dysfunction studies
- Tissue Engineering and Regenerative Medicine
- Veterinary Pharmacology and Anesthesia
- Electrospun Nanofibers in Biomedical Applications
- Anesthesia and Pain Management
- Urinary Tract Infections Management
- Hormonal and reproductive studies
- Pharmacological Receptor Mechanisms and Effects
- Pregnancy-related medical research
- Spinal Cord Injury Research
- Gastrointestinal motility and disorders
- Anorectal Disease Treatments and Outcomes
- Ion Channels and Receptors
- Neurotransmitter Receptor Influence on Behavior
- Eicosanoids and Hypertension Pharmacology
- Veterinary Equine Medical Research
- Veterinary Medicine and Surgery
Dignify Therapeutics (United States)
2016-2024
Triangle
2016-2023
Durham University
2012-2014
Astellas Pharma (Japan)
2013-2014
Astellas Pharma (United States)
2010-2013
Indiana University – Purdue University Indianapolis
1994-2009
Duke University
2002-2008
Duke University Hospital
1999-2008
Duke Medical Center
1999-2008
Durham VA Medical Center
2000-2006
No AccessJournal of UrologyInvestigative Urology1 Jun 1996Regenerative Urinary Bladder Augmentation Using Small Intestinal Submucosa: Urodynamic and Histopathologic Assessment in Long-term Canine augmentations Bradley P. Kropp, Marian K. Rippy, Stephen F. Badylak, Mark C. Adams, Michael A. Keating, Richard Rink, Karl B. Thor KroppBradley Kropp More articles by this author , RippyMarian Rippy BadylakStephen Badylak AdamsMark Adams KeatingMichael Keating RinkRichard Rink ThorKarl View All...
Because all three components of lower urinary tract control (parasympathetic, sympathetic and somatic) are intimately associated with serotonin (5-hydroxytryptamine [5HT])- norepinephrine (NE)- containing terminals receptors, in the present study, we examined effects increasing extracellular levels 5HT NE duloxetine, a reuptake inhibitor, on function under "normal" or nonirritated conditions (transvesical infusion saline) model bladder irritation (i.e., transvesical 0.5% acetic acid)...
Application of horseradish peroxidase to the pudendal nerve in female cat labelled lumbosacral afferent and efferent neurons their processes. Afferent axons entered spinal cord primarily at S1 S2 segments traveled rostrocaudally Lissauer's tract dorsal columns. A distinctive component column projection was located lamina I-dorsal border as a densely labelled, compact bundle that distributed fibers horn levels near entry axons. terminal labelling marginal zone, intermediate gray matter,...
We characterized small intestinal submucosa regenerated canine bladder.We subjected 15-month bladder strips to in vitro muscle bath compliance, contractility testing and immunohistochemical staining.Compliance studies demonstrated no significant difference between control bladders, which were 30-fold more compliant than native submucosal graft material. Contractility contractile responses innervation similar those of normal bladder. Afferent nerves through techniques.These characteristics...
alpha1-Adrenergic receptor (alpha1AR) antagonists are effective for relieving obstructive and irritative symptoms in patients with bladder outlet obstruction. While the alpha1aAR is responsible prostate smooth muscle relaxation obstruction relief, to our knowledge mechanisms underlying relief of remain be determined. Therefore, we investigated by which alpha1AR subtypes may involved this process.We studied 42 rats, including 6 unoperated controls, 17 sham operated controls 19 obstructed...
No AccessJournal of UrologyInvestigative Urology1 Jan 1996Detrusor Regeneration in the Rat Using Porcine Small Intestinal Submucosal Grafts: Functional Innervation and Receptor Expression J.D. Vaught, B.P. Kropp, B.D. Sawyer, M.K. Rippy, S.F. Badylak, H.E. Shannon, K.B. Thor VaughtJ.D. Vaught , KroppB.P. Kropp SawyerB.D. Sawyer RippyM.K. Rippy BadylakS.F. Badylak ShannonH.E. Shannon ThorK.B. View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66663-1AboutFull TextPDF ToolsAdd to...
1. 5-Hydroxytryptamine (5-HT) is intimately associated with central sympathetic and somatic control of the lower urinary tract. The innervation tract conveyed through efferent axons hypogastric pudendal nerves, respectively. 2. present study examined effects 2,5-dimethoxy-4-iodophenylisopropylamine (DOI), a 5-HT2 receptor subtype-selective agonist, on evoked potentials recorded from ends nerves in response to electrical stimulation afferent fibres pelvic Various spinalization paradigms were...
No AccessJournal of UrologyInvestigative Urology1 Apr 1995Inhibition Central Sympathetic and Somatic Outflow to the Lower Urinary Tract Cat by Alpha sub 1 Adrenergic Receptor Antagonist Prazosin Hansjorg Danuser Karl B. Thor DanuserHansjorg More articles this author ThorKarl Requests for reprints: Division CNS Research, Eli Lilly Co., Indianapolis, Indiana 46285. View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67591-8AboutFull TextPDF ToolsAdd favoritesDownload...
The effects of 3 competitive N‐methyl‐ d ‐aspartate (NMDA) receptor antagonists, LY274614, LY233536 and LY235723, on the micturition reflex external urethral sphincter EMG activity, were examined either under isovolumetric conditions or during continuous filling cystometry in urethane‐anaesthetized (1.2 g kg −1 , s.c.) rats. Intravenous administration LY274614 (3–30 mg ) inhibited a dose‐dependent fashion both bladder activity intact In addition, volume threshold for inducing was increased...