A5038903460- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Dementia and Cognitive Impairment Research
- Mental Health and Patient Involvement
- Biomedical Ethics and Regulation
- Pharmaceutical Economics and Policy
- BRCA gene mutations in cancer
- CRISPR and Genetic Engineering
- Pain Mechanisms and Treatments
- Health Policy Implementation Science
- Plant and Fungal Species Descriptions
- Mental Health and Psychiatry
- Climate Change Communication and Perception
- Palliative Care and End-of-Life Issues
- Patient-Provider Communication in Healthcare
- Health, Environment, Cognitive Aging
- Musculoskeletal pain and rehabilitation
- Streptococcal Infections and Treatments
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Plant Parasitism and Resistance
- Race, Genetics, and Society
- Acupuncture Treatment Research Studies
- Transgenic Plants and Applications
- Genomics and Rare Diseases
University of Cambridge
2016-2025
Wellcome Connecting Science
2018-2025
Wellcome Sanger Institute
2025
Amsterdam Neuroscience
2023
Amsterdam University Medical Centers
2023
University of Exeter
2021-2023
University of Suffolk
2022
University of Edinburgh
2020
Aker BP (Norway)
2020
University of Auckland
1987-2018
The responses of 66 primate spinothalamic neurons to natural stimulation the urinary bladder and testicle were studied with extracellular recording techniques in order elucidate neural basis for referral visceral pain. Thirty-eight out 53 cells located at thoraco-lumbar junction or sacral segments responded noxious cutaneous stimuli, 84% these also exhibited phasic and/or tonic excitatory distension bladder. Seventeen 20 units, all junction, excited by compression ipsilateral testicle....
Analyzing genomic data across populations is central to understanding the role of genetic factors in health and disease. Successful sharing relies on public support, which requires attention whether people around world are willing donate their that then subsequently shared with others for research. However, studies such perceptions geographically limited do not enable comparison. This paper presents results from a very large survey attitudes toward sharing. Data 36,268 individuals 22...
Abstract Trust may be important in shaping public attitudes to genetics and intentions participate genomics research big data initiatives. As such, we examined trust sharing among the general public. A cross-sectional online survey collected responses from representative publics USA, Canada, UK Australia ( n = 8967). Participants were most likely their medical doctor less other entities named. Company researchers least trusted. Low, Variable High classes defined using latent class analysis....
Abstract Background Public trust is central to the collection of genomic and health data sustainability research. To merit trust, those involved in collecting sharing need demonstrate they are trustworthy. However, it unclear what measures most likely this. Methods We analyse ‘Your DNA, Your Say’ online survey public perspectives on including responses from 36,268 individuals across 22 low-, middle- high-income countries, gathered 15 languages. examine how participants perceived relative...
Aim: To estimate acute rheumatic fever (ARF) incidence rates for New Zealand children and youth by ethnicity, socioeconomic deprivation region. Methods: National hospital admissions with a principal diagnosis of ARF (ICD9_AM 390‐392; ICD10‐AM I00‐I02) were obtained from routine statistics stratified age, index (NZDep2006) District Health Board (DHB). Results: The mean rate in 2000–2009 peaked at 9 to 12 years age. Incidence 5 14 age Māori 40.2 (95% confidence interval 36.8, 43.8), Pacific...
Background Low participation in research is one of the key challenges to advancing understanding dementia, and improving care treatment those who live with this condition. Nurses nurse researchers play a vital role recruiting people dementia studies, as several countries including United States Kingdom set national targets develop initiatives encourage more take part research. Aim To highlight identify strategies that nurses, particular, can use for overcoming them. Our focus primarily on...
With the use of genetic technology, researchers have potential to inform medical diagnoses and treatment in actionable ways. Accurate variant interpretation is a necessary condition for utility technology unfold. This relies on ability access large genomic datasets so that comparisons can be made between variants interest. only successful if DNA data are donated by numbers people 'research', including clinical, non-profit for-profit research initiatives, order accessed scientists clinicians...
Recent approvals of amyloid immunotherapy drugs for early Alzheimer's disease (AD) have been highly controversial. In this piece, we consider challenges from the clinical, population health, and health systems perspectives to role that new AD might be expected play, now in future, alleviating morbidity caused by population. Clinically, short-term effects are small, adverse events frequent, treatment regimens burdensome, and, crucially, long-term unknown. At a level, there is always likely...
The importance of date labelling in informing both retailers and consumers how long a food will remain edible, safe sufficient quality makes it prime site for the identification of, intervention in, waste. This paper examines historical spatial evolution system UK. shows reforms to marking have occurred response shifting concerns about quality, safety latterly It distinguishes four periods during which labels moved from an internal stock control mechanism consumer protection mechanism,...
In clinical trials which target pathophysiological mechanisms associated with Alzheimer’s disease, research participants who are recruited based on biomarker test results should be informed about their increased risk of developing dementia. This paper presents the a qualitative focus group study attitudes and concerns toward learning information biomarker-based status among healthy in United Kingdom Spain people dementia supporters/caregivers from countries represented European Working Group...
1. This study examined the relationship between perceived heaviness of a weight and reflexes acting on motoneurones required for contraction. The low (100 g) high (500 reference weights lifted by first dorsal interosseous muscle was estimated using matching task. Weights were also during stimulation digital nerves index finger at two times four sensory threshold (T). Averages force EMG made when isometric forces 100 500 g maintained. 2. Stimuli 4T produced significant increase in each...
Aims: To estimate the annual mortality and cost of hospital admissions for acute rheumatic fever (ARF) heart disease (RHD) New Zealand residents. Methods: Hospital in 2000–2009 with a principal diagnosis ARF or RHD (ICD9_AM 390‐398; ICD10‐AM I00‐I099) deaths 2000–2007 as underlying cause were obtained from routine statistics. The each admission was estimated by multiplying its diagnosis‐related group (DRG) weight national price financial year 2009/2010. Results: There on average 159 mean...
Abstract Biomedical research aimed at the development of therapies for chronic and late‐onset conditions increasingly concentrates on early treatment symptom‐less disease. This broad trend is evidenced in prominent shifts contemporary dementia research. Revised diagnostic criteria new approaches to clinical trials propose a focus earlier stages disease prompt concerns about implications communicating test results associated with risk developing when no effective treatments are available....