A5038842315- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Cellular Mechanics and Interactions
- Micro and Nano Robotics
- Genetic and Kidney Cyst Diseases
- 3D Printing in Biomedical Research
- Microtubule and mitosis dynamics
- Magnetic and Electromagnetic Effects
- Tissue Engineering and Regenerative Medicine
- Lymphatic System and Diseases
- Wound Healing and Treatments
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Characterization and Applications of Magnetic Nanoparticles
- Molecular Junctions and Nanostructures
- Dialysis and Renal Disease Management
- Osteoarthritis Treatment and Mechanisms
- Reproductive Biology and Fertility
- Skin and Cellular Biology Research
- Polymer Surface Interaction Studies
- Total Knee Arthroplasty Outcomes
- Corneal Surgery and Treatments
- Dendrimers and Hyperbranched Polymers
- Cell Adhesion Molecules Research
Washington University in St. Louis
2020-2025
Center for Life Sciences
2019-2022
Tsinghua University
2018-2022
Despite the wide applications, systematic mechanobiological investigation of 3D porous scaffolds has yet to be performed due lack methodologies for decoupling complex interplay between structural and mechanical properties. Here, we discover regulatory effect cryoprotectants on ice crystal growth use this property realize separate control scaffold pore size stiffness. Fibroblasts macrophages are sensitive both properties gelatin scaffolds, particularly sizes. Interestingly, within smaller...
In knee osteoarthritis (OA), there is more pronounced cartilage damage in the medial compartment ("lesion zone") than lateral ("remote zone"). This study fills a gap literature by conducting systematic comparison of and chondrocyte characteristics from these two zones. It also investigates whether chondrocytes different zones respond distinctly to changes physical mechanical microenvironment using three-dimensional porous scaffolds changing stiffness pore size. Cartilage was harvested...
Chronic kidney diseases are widespread and incurable. The biophysical mechanisms underlying them unclear, in part because material systems for reconstituting the microenvironment of relevant cells limited. A critical question is how podocytes (glomerular epithelial cells) regenerate foot processes filtration apparatus following injury. Recently identified sarcomere-like structures (SLSs) with periodically spaced myosin IIA synaptopodin appear injured vivo. We hypothesized that SLSs template...
Biointegration of a keratoprosthesis (KPro) is critical for the device stability and long-term retention. KPro host tissue takes place between surrounding corneal graft central optic (made by poly (methyl methacrylate)). Our previous clinical results showed that auricular cartilage reinforcement able to enhance biointegration. However, non-renewable difficult acquire. In this study, we developed novel type biomaterial using three-dimensional porous polyethylene glycol acrylate scaffold (3D...
Qu, Chengqing; Jiang, Shumeng; Genin, Guy M.; Suleiman, Hani; Miner, Jeffrey H. Author Information
Abstract Chronic kidney diseases are widespread and incurable. The biophysical mechanisms underlying them unclear, in part because material systems for reconstituting the microenvironment of relevant cells limited. A critical question is how podocytes (glomerular epithelial cells) regenerate foot processes filtration apparatus following injury. Recently identified sarcomere-like structures (SLSs) with periodically spaced myosin IIA (a contractile protein) synaptopodin (an actin-associated...