A5020002036- Cellular Mechanics and Interactions
- Wound Healing and Treatments
- 3D Printing in Biomedical Research
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Electrospun Nanofibers in Biomedical Applications
- Cancer Cells and Metastasis
- Tendon Structure and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Collagen: Extraction and Characterization
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Cardiac Imaging and Diagnostics
- Advanced Materials and Mechanics
- Cardiac Ischemia and Reperfusion
- Automotive and Human Injury Biomechanics
- Traumatic Brain Injury Research
Washington University in St. Louis
2017-2025
Johns Hopkins University
2024-2025
Johns Hopkins Medicine
2025
UCLouvain Saint-Louis Brussels
2022
Golestan University of Medical Sciences
2012-2017
Golestan University
2012-2014
Fibroblasts undergo a critical transformation from an initially inactive state to morphologically different and contractile after several hours of being embedded within physiologically relevant three-dimensional (3D) fibrous collagen-based extracellular matrix (ECM). However, little is known about the mechanisms by which fibroblasts adapt themselves their microenvironment in earliest stage cell–matrix interaction. Here, we identified interact with 3D collagen matrices early stages...
Mechanical stretch can activate long-lived changes in fibroblasts, increasing their contractility and initiating phenotypic transformations. This activation, critical to wound healing procedures such as skin grafting, increases with mechanical stimulus for cells cultured two-dimensional but is highly variable three-dimensional (3D) tissue. Here, we show that static of 3D tissues either increase or decrease fibroblast activation depending upon recursive cell–extracellular matrix (ECM)...
Abstract Mechanical factors such as stress in the extracellular environment are known to affect phenotypic commitment of cells. However, fields experienced by cells tissues multiaxial, and ways that integrate this multiaxial information largely unknown. Here, we report anisotropy these is a critical factor triggering transition fibroblast cells, outweighing previously reported role amplitude. Using combined experimental computational approach, discovered self-reinforcing mechanism which...
Simvastatin (SV) leads to reduction of ventricular rhythm during atrial fibrillation on rabbit atrioventricular (AV) nodes. The aim our study was (i) determine the frequency-dependent effects SV in a functional model, and (ii) assess suppress experimental AV nodal reentrant tachycardia (AVNRT). Selective stimulation protocols were used with two different pacing protocols, His atrial, (AA). An AVNRT model various cycle lengths created three groups perfused preparations (n = 24) including: 3...
Abstract Mechanical stretching of living tissues can activate long-lived changes in tissue cells such as fibroblasts, increasing their contractility and initiating phenotypic transformations. Increased mechanical stimulus typically leads to monotonically activation fibroblasts cultured 2D, but levels are difficult predict for 3D fibrous tissues, leading variable outcomes procedures skin grafting. Here we report that the source this variation is cell-extracellular matrix (ECM) interactions...