A5101414525- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Polysaccharides and Plant Cell Walls
- Allergic Rhinitis and Sensitization
- Fungal Biology and Applications
- Mast cells and histamine
- Photodynamic Therapy Research Studies
- Natural product bioactivities and synthesis
- Bioactive natural compounds
- IL-33, ST2, and ILC Pathways
- Phytochemistry and Biological Activities
- Advancements in Transdermal Drug Delivery
- Nanoplatforms for cancer theranostics
- Pharmacological Effects of Natural Compounds
- Nephrotoxicity and Medicinal Plants
- Bone Metabolism and Diseases
- Urticaria and Related Conditions
- Spine and Intervertebral Disc Pathology
- Bone health and osteoporosis research
- Microencapsulation and Drying Processes
- Insect Utilization and Effects
- Bone Tissue Engineering Materials
- Ocular Infections and Treatments
- Immune responses and vaccinations
- Drug Transport and Resistance Mechanisms
Chinese University of Hong Kong
2016-2025
University of Hong Kong
2002-2023
Queen Mary Hospital
2023
University of British Columbia
2016
Prince of Wales Hospital
2001-2011
United States Department of Agriculture
1980-1989
Atopic dermatitis (AD) is a common allergic skin disease, characterized by dryness, itchiness, thickening and inflammation of the skin. Infiltration eosinophils into dermal layer presence edema are typical characteristics in biopsy AD patients. Previous vitro clinical studies showed that Pentaherbs formula (PHF) consisting five traditional Chinese herbal medicines, Flos Lonicerae, Herba Menthae, Cortex Phellodendri, Moutan Rhizoma Atractylodis at w/w ratio 2:1:2:2:2 exhibited therapeutic...
Abstract The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although wide variety complementary therapies have introduced, they fail to combine skin moisturizing and drug supply for AD patients. This study reports development thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions moisture treatment. It was found that presence CMCs can appreciably improve physical...
Abstract Interleukin-38 has recently been shown to have anti-inflammatory properties in lung inflammatory diseases. However, the effects of IL-38 viral pneumonia remains unknown. In present study, we demonstrate that circulating concentrations together with IL-36α increased significantly influenza and COVID-19 patients, level correlated negatively positively disease severity inflammation, respectively. co-cultured human respiratory epithelial cells macrophages mimic microenvironment vitro,...
A polysaccharide (GSP-6B) with a molecular mass of 1.86 × 106 Da was isolated from the fruiting bodies Ganoderma sinense. Chemical composition analysis, methylation infrared spectroscopy, and nuclear magnetic resonance spectroscopy were conducted to elucidate its structure. GSP-6B contains backbone (1→6)-linked-β-d-glucopyranosyl residues, bearing branches at O-3 position every two sugar residues along backbone. The side chains contain (1→4)-linked-β-d-glucopyranosyl...
Pentaherb formula (PHF) has been proven to improve the quality of life children with atopic dermatitis without side effects. The aim this study was elucidate potential anti-inflammatory and anti-allergic activities PHF, Moutan Cortex (Danpi/DP) gallic acid (GA) using human basophils (KU812 cells), which are crucial effector cells in allergic inflammation. DP GA could significantly suppress expression inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, release...
Abstract Objectives The aims of this study were to identify the active ingredients from Portulaca oleracea L. (PO) that could provide synergism with antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) and their possible mechanisms resistance inhibition. Methods High-speed counter-current chromatography (HSCCC) coupled gas chromatography-mass spectrometry a panel laboratory MRSA strains used for checkerboard efflux inhibitory assays. Key findings Linoleic oleic acids...
Eczema is a chronic relapsing atopic dermatitis (AD) associated with pruritus, sleep disturbance and poor quality of life the patient. Treatment eczema includes use emollient, topical systemic antimicrobial agents, corticosteroid or immunomodulating agents. Many patients also seek alternative treatments such as dietary avoidance, supplementation both. This article reviews basic pathophysiology clinical trials involving Chinese medicine in treatment eczema. Research reports on herbal for were...
A polysaccharide named GSP-2 with a molecular size of 32 kDa was isolated from the fruiting bodies Ganoderma sinense. Its structure well elucidated, by combined utilization chemical and spectroscopic techniques, to be β-glucan backbone (1→4)– (1→6)–Glcp, bearing terminal- (1→3)–Glcp side-chains at O-3 position (1→6)–Glcp. Immunological assay exhibited that significantly induced proliferation BALB/c mice splenocytes target on only B cells, enhanced production several cytokines in human...