A5041808513- Nanoparticle-Based Drug Delivery
- 3D Printing in Biomedical Research
- Advanced X-ray Imaging Techniques
- Advanced biosensing and bioanalysis techniques
- Surface Modification and Superhydrophobicity
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Electrospun Nanofibers in Biomedical Applications
- Laser-Plasma Interactions and Diagnostics
- Nanoparticles: synthesis and applications
- Lipid Membrane Structure and Behavior
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- DNA and Nucleic Acid Chemistry
- Atomic and Molecular Physics
- Advanced Electron Microscopy Techniques and Applications
- Biosensors and Analytical Detection
- X-ray Spectroscopy and Fluorescence Analysis
- Nanofabrication and Lithography Techniques
- Laser Design and Applications
- Bone Tissue Engineering Materials
- Microfluidic and Bio-sensing Technologies
- Force Microscopy Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
Polytechnic University of Turin
2017-2024
University of Turin
2012-2024
King Abdullah University of Science and Technology
2014-2019
Italian Institute of Technology
2012-2014
University of L'Aquila
1999-2010
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Gran Sasso
2001-2008
Istituto Nazionale di Fisica Nucleare
2008
At present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to techniques involved oncological field, then summarize NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, metal oxide NPs....
This review covers several aspects of microfluidic devices used for culturing and monitoring both adherent non-adherent cells, including a multitude applications. A comparison available platforms with high throughput analysis, automation capability, interface to sensors integration, is reported. Aspects, such as operational versatility the devices, are scrutinized in terms their analytical efficacy. It found that due multi-functionality capability modern microfluidics, there big amount...
The aim of this study was the design a 3D scaffold composed poly(vinyl) alcohol (PVA) for cardiac tissue engineering (CTE) applications. PVA fabricated using combination gas foaming and freeze-drying processes that did not need any cross-linking agents. We obtained biocompatible porous matrix with excellent mechanical properties. measured stress-strain curves scaffolds we showed elastic behavior is similar to extracellular muscles. SEM observations revealed possess micro pores having...
The surface chemistry and charge of zinc oxide nanocrystals influence their behaviour in biological fluids. A novel lipid bilayer assembly is developed to shield ZnO improving stability cell internalization.
Direct imaging becomes important when the knowledge at few/single molecule level is requested and where diffraction does not allow to get structural functional information. Here we report on direct of double stranded (ds) λ-DNA in A conformation, obtained by combining a novel sample preparation method based super hydrophobic DNA molecules self-aggregation process with transmission electron microscopy (TEM). The experimental breakthrough production robust highly ordered paired nanofibers that...
Abstract The generation of 3D networks primary neurons is a big challenge in neuroscience. Here, novel method presented for neuronal culture on superhydrophobic (SH) substrates. How nano‐patterned SH devices stimulate to build investigated. Scanning electron microscopy and confocal imaging show that soon after plating neurites adhere the nanopatterned pillar sidewalls they are subsequently pulled between pillars suspended position. These display an enhanced survival rate compared standard...
Herein we report a novel, easy, fast and reliable microwave-assisted synthesis procedure for the preparation of colloidal zinc oxide nanocrystals (ZnO NCs) optimized biological applications. ZnO NCs are also prepared by conventional solvo-thermal approach properties two families compared discussed. All fully characterized in terms morphological analysis, crystalline structure, chemical composition optical properties, both as pristine nanomaterials or after amino-propyl group...
Novel nanoarray for single molecule detection from peptide mixture.
The structure of DNA was determined in 1953 by x-ray fiber diffraction. Several attempts have been made to obtain a direct image with alternative techniques. is intended allow quantitative evaluation all relevant characteristic lengths present molecule. A DNA, which different from diffraction the reciprocal space, difficult for two main reasons: intrinsic very low contrast elements that form molecule and difficulty preparing sample while preserving its pristine shape size. We show through...
Aim:The effective application of nanoparticles in cancer theranostics is jeopardized by their aggregation biological media, rapid degradation and clearance.The design biomimetic nanoconstructs with enhanced colloidal stability non-immunogenicity therefore essential.We propose naturally stable cell-derived extracellular vesicles to encapsulate zinc oxide (ZnO) nanocrystals as efficacious nanodrugs, obtain highly Trojan nano-horses (TNHs).Materials & methods: Coupling efficiency, biostability,...
In the last years, different nanotools have been developed to fight cancer cells. They could be administered alone, exploiting their intrinsic toxicity, or remotely activated achieve cell death. latter case, ultrasound (US) has recently proposed stimulate some nanomaterials because of US outstanding property deep tissue penetration and possibility focusing. this study, for first time, we report on highly efficient killing capability amino-propyl functionalized ZnO nanocrystals (ZnO NCs) in...
We propose an efficient method to modify B-cell derived EVs by loading them with a nanotherapeutic stimuli-responsive cargo and equipping antibodies for targeting of lymphoma cells.The post-isolation engineering the is accomplished freeze-thaw load therapeutically-active zinc oxide nanocrystals (ZnO NCs), obtaining so-called TrojanNanoHorse (TNH) recall biomimetism cytotoxic potential this novel nanoconstruct. TNHs are further modified at their surface anti-CD20 monoclonal (TNHCD20)...
Cancer is one of the leading causes death worldwide and represents a significant burden on global health systems. Many existing chemotherapy treatments come with severe side effects, ranging from...
The use of lithium fluoride (LiF) crystals and films as imaging detectors for EUV soft-x-ray radiation is discussed. or can generate stable color centers, emitting in the visible spectral range an intense fluorescence from exposed areas. high dynamic response material to received dose atomic scale centers make this detector extremely interesting at a spatial resolution which be much smaller than light wavelength. Experimental results contact microscopy test meshes demonstrate order 400nm....