The present study evaluated the effects of curcumin on epithelial cell apoptosis, immunoreactivity phospho–c-Jun N-terminal kinase (JNK) and phospho-p38 mitogen-activated protein kinases (MAPKs) in inflamed colon mucosa, oxidative stress a rat model ulcerative colitis induced by acetic acid. Rats were randomly divided into three groups: control, acid, acid+curcumin. Curcumin (100 mg/kg per day, intragastrically) was administered 10 days before induction continued for two additional days....

We investigated possible effects of proanthocyanidin (PA) and vitamin E on damage to rat kidneys induced by formaldehyde (FA), using biochemical characteristics light electron microscopy. Male rats were divided into control, FA, PA treated groups. Kidney tissue was observed Bcl-2/Bax rate measured immunohistochemistry. Malondialdehyde (MDA) total sialic acid (TSA) levels, superoxide dismutase (SOD), glutathione peroxidase (Gpx), catalase (CAT) myeloperoxidase (MPO) activities measured. found...

Sitagliptin increases the levels of incretin hormones and stimulates a decrease in blood glucose levels, by blocking DPP4 enzyme. We have very limited information about impact sitagliptin on male genital system relationship between sitagliptin/diabetes/ER. Fucoidan can be effective homeostasis. goal to explain effect introduce an approach fucoidan treatment experimental diabetes rats. Fifty-eight Wistar albino rats were divided into C-control group D-diabetes group: 60 mg/kg streptozotocin...

We aimed to investigate of protective role proanthocyanidin (PA) and vitamin E (vit E) against toxic effect formaldehyde (FA). Twenty-eight Wistar albino rats were divided into four groups: control group, treated with FA intraperitoneal (i.p.) (10 mg/kg), + vit intragastric (i.g.) (30 PA i.g. (100 mg/kg). assayed superoxide dismutase (SOD), glutathione peroxidase (Gpx), myeloperoxidase (MPO) activity levels malondialdehyde (MDA) total sialic acid (TSA) in liver. Liver tissue was taken order...

We aimed to evaluate the ultrastructural effect of reversing cellular damage, occurring in rats due ischemia-reperfusion (I/R) intestine, with naringin implementation through biochemical parameters. Rats were divided sham/control, I/R and groups (n = 7). For group, 120 min ischemia reperfusion was applied superior mesenteric artery. In after min, 50 mg/kg implemented, then applied. Morphological evaluation performed via Chiu score electron microscopy. The antioxidant parameters examined. (p...

We investigated the effects of naringin on small intestine, liver, kidney and lung recovery after ischemia/reperfusion (I/R) injury gut. Rats were divided randomly into four groups eight. Group A was sham control; group B ischemic for 2 h; C h re-perfused (I/R); D treated with 50 mg/kg ischemia, then h. Endothelial nitric oxide synthase (eNOS) inducible (iNOS) expressions detected by immunolabeling. also measured arginase activity, amounts (NO) total protein. iNOS increased significantly in...

Background and Objective: An ischemia-reperfusion (I/R) injury of small intestine is a serious common condition that result the blockage Superior Mesenteric Artery (SMA) because significant clinical problems.This study aimed to evaluate effects antioxidant mesna on intestinal nitric oxide (NO) levels arginase activity in I/R at biochemical immunohistochemical determine tissue malondialdehyde (MDA) level as marker oxidative damage.Methodology: In study, 10-12 week-old male Wistar albino rats...

The present study investigated the effect of methyleugenol, a food flavoring and fragrance agent, on livers laboratory rats. Doses 10 30 mg/kg/day methyleugenol (in 0.5% methylcellulose) were administered intragastrically (IG) to 2 dose groups for days alongside control group (n = each group). Gains in body weight not statistically significant either dose. Lactate dehydrogenase (LDH) alkaline phosphatase (ALP) activities decreased (P < 0.05) both groups, but AST (aspartate aminotransferase)...

An ischemia/reperfusion (IR) injury of small intestine is a serious and common condition that result the blockage superior mesenteric artery (SMA) due to some significant clinical problems. In present study, we evaluated effect Mesna on systemic induced by IR in liver, kidney lung rats. Thirty-two Wistar albino female rats were randomly divided into four groups as control, ischemia, (Sham) IR+Mesna. Ischemia period was executed clamping SMA for 2 h after when reperfusion permitted removing...

In the present study, acute toxic effects of endosulfan on thyroid glands were investigated by light and electron microscopy. Endosulfan (LD30 4.16 mg/kg) was injected intraperitoneally into adult male mice. microscopic studes, it observed that some follicles had been damaged joined together. Furthermore, colloidal fluids diffused from dispersed connective tissues. Swelling in endoplasmic reticulum sacs, expansion perinuclear area, pycnotic nuclei accumulation heterochromatin determined

2,2,4,4,5-Pentabromo diphenyl ether (BDE-99), one of the polybrominated ethers (PBDE) species are a commercially available chemical substance used as flame retardant on large scale.The use BDE-99 such scale provides further investigation its effects live mechanism due to this pollutant may be exposed seafood, air, water, household wastes and dust, well most important exposure route is nutrition.Therefore we aim investigate gene expression changes apoptotic acute oxidative enzyme induced by...

Çalışmamızın amacı, diyabetik testis dokularında gözlenen hasarlarda etkili olabilme potansiyeli yüksek bir antioksidan olan fukoidanın, spermatogenez seri hücrelerine proliferasyon, apoptozis ve inflamasyon yönünden olası etkilerini araştırmaktır. Fukoidan; çeşitli amaçlarla tablet formunda tüketici kullanımına sunulmuş olmasına rağmen, diyabetli erkek hastalarda infertiliteye yönelik değerlendirme yapabilmek için yeterli veriler bulunmamaktadır. Bu amaçla, dokusunda prolifere hücre nükleer...

We investigated how proanthocyanidin treatment altered c-Jun N-terminal kinases, transforming growth factor beta 1, serine/threonine-specific protein kinase, interleukin 1 and insulin-like 3 expression in the testis of diabetic rats. used 24 Wistar albino male rats divided into four groups. Group was untreated control. 2 treated with 40 mg/kg streptozotocin (STZ) for 5 days. STZ + 250 once daily six weeks. 4 proanthocyanidin. Superoxide dismutase activity reduced groups compared to group 2....