A5102725259- Plant Toxicity and Pharmacological Properties
- Sesquiterpenes and Asteraceae Studies
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- Circular RNAs in diseases
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Histone Deacetylase Inhibitors Research
- Ferroptosis and cancer prognosis
- Mechanisms of cancer metastasis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Photoreceptor and optogenetics research
- Advanced Fluorescence Microscopy Techniques
- Plant Diversity and Evolution
- Plant and Fungal Species Descriptions
- Chromatin Remodeling and Cancer
- Sirtuins and Resveratrol in Medicine
- Photochromic and Fluorescence Chemistry
- Liver Disease Diagnosis and Treatment
- Botanical Research and Chemistry
- Metastasis and carcinoma case studies
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
Jiangxi University of Traditional Chinese Medicine
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Weill Cornell Medicine
2016
Cornell University
2016
Peking University
2014
Peking University Cancer Hospital
2014
Shandong University
2008-2014
Jiangsu Cancer Hospital
2010
Abstract Colorectal cancer (CRC), a fatal tumor, has been diagnosed as one of the most prevalent types cancers globally, inducing multiple cancer‐linked deaths. Mounting evidence revealed that circular RNA (circRNA) elicits regulatory impact on initiation and development cancers. Emerged new circRNA, hsa_circ_0000677 (circ‐ABCC1) not studied in progression. This study is first attempt to explore role circ‐ABCC1 CRC. In this study, data from sphere‐forming, transwell, Western blot analyses...
40-50% of colorectal cancer (CRC) patients develop metastatic disease; the presence metastasis hinders effective treatment through surgery, chemotherapy and radiotherapy, which makes 5-year survival rate extremely low; therefore, studying CRC is crucial for disease therapy. In present study, we investigated role rhomboid domain containing 1 (RHBDD1) in tumor CRC.The expression RHBDD1 was analyzed 539 tissues its correlation with lymphatic distal metastasis. Transwell assay vitro pleural...
Bright, long-lasting organic fluorophores enable a broad range of imaging applications. "Self-healing" fluorophores, in which intra-molecularly linked protective agents quench photo-induced reactive species, exhibit both enhanced photostability and biological compatibility. However, the self-healing strategy has yet to achieve its predicted potential, particularly presence ambient oxygen where live-cell studies must often be performed. To identify key bottlenecks this technology that can...
Tribe Theeae, which includes some economically important and widely grown plants, such as beverage tea a number of woody ornamentals, is the largest member Theaceae family. Using five genomic regions (chloroplast: atpI-H, matK, psbA5'R-ALS-11F, rbcL; nuclear: LEAFY) 30 species representing four genera in this tribe (Apterosperma, Camellia, Polyspora, Pyrenaria s.l.), we investigated phylogeny Theeae assessed delimitation tribe. Our results showed that Polyspora was monophyletic sister three...
MicroRNA-150-5p (miR-150-5p) has been implicated in the progression of several cancer types, yet its specific functional role and regulatory mechanisms bladder (BC) remain largely unexplored. Our study revealed significant downregulation miR-150-5p upregulation NEDD4-binding protein 2-like 1 gene (N4BP2L1) BC tissues compared to controls using quantitative real-time polymerase chain reaction western blot analysis, respectively. Reduced expression correlated with advanced tumor stage lymph...
Abstract A new eremophilane dimer, namely fischelactone B, was isolated from the roots of Ligularia fischeri . Its structure established on basis spectroscopic data, including IR, HR‐ESI‐MS, and 1D NMR 2D spectroscopy.
A new eremophilane sesquiterpene was isolated from the roots of Senecio nemorensis. Its structure established as 10α-hydroxy-6β-propionyloxy-1-oxoeremophila-7(11),8-dieno-12,8-lactone on basis spectral analysis.
Abstract Anew farnesene derivative, 7R*,10S*‐epoxy‐3 E ,5 ‐farnesadien‐1,2,11‐triol, along with eight known compounds was isolated from the aerial parts of Senecio cannabifolius . Their structures were established on basis spectroscopic methods.
A new sesquiterpenoid eremophilenolactone and three known compounds were isolated from the MeOH extract of aerial parts Senecio nemorensis L. Their structures elucidated on basis spectroscopic evidence including IR, HR-ESI-MS, 1D 2D NMR techniques. The compound was established as 8α-hydroxy-6β-(isobutanoyloxy)-eremophila-7(11),1(10)-dieno-12,8β-lactone.
Investigation of the aerial parts Senecio ambraceus afforded four eudesmane-type sesquiterpenes (1–4), which 1 was isolated from a natural source for first time. Its structure established on basis spectroscopic methods, including IR, EI–MS, HR–ESI–MS, 1D and 2D NMR spectroscopy.