A5014597054- Cancer-related molecular mechanisms research
- Retinal Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- TGF-β signaling in diseases
- Circular RNAs in diseases
- Corneal Surgery and Treatments
- Autophagy in Disease and Therapy
- Hedgehog Signaling Pathway Studies
- Protein Degradation and Inhibitors
- Angiogenesis and VEGF in Cancer
- Inhalation and Respiratory Drug Delivery
- Salivary Gland Tumors Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Retinal and Optic Conditions
- Uterine Myomas and Treatments
- Stress Responses and Cortisol
- Endometrial and Cervical Cancer Treatments
- Sirtuins and Resveratrol in Medicine
- Proteoglycans and glycosaminoglycans research
- Pancreatic and Hepatic Oncology Research
- ATP Synthase and ATPases Research
- Metabolism, Diabetes, and Cancer
- Microbial Community Ecology and Physiology
- Vibrio bacteria research studies
Shantou University
2023
Shantou University Medical College
2023
Tokyo Medical and Dental University
2021-2022
Nippon Medical School
2021
Union Hospital
2021
Jilin University
2021
Hebei Medical University
2021
Second Hospital of Hebei Medical University
2021
Yangtze River Pharmaceutical Group (China)
2020
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2019
Asthma is a chronic disease related to airway hyperresponsiveness and remodeling. Airway remodeling the important reason of refractory asthma associated with differentiation epithelia into myofibroblasts via epithelial-mesenchymal transition (EMT) increase process subepithelial fibrosis. There growing evidence that autophagy modulates However, underlying molecular mechanisms these effects are still unclear. In this study, we hypothesized Follistatin-like 1 (FSTL1) promotes EMT by...
Significance Skeletal muscle atrophy occurs as a result of variety conditions including aging, disuse, and cachexia. In this study, we show that the transcription factor KLF5 is transiently up-regulated by metabolic disuse stimulations plays pivotal role in onset vitro vivo. physically interacts with Foxo1, together, they regulate Fbxo32 , key atrophy-inducing ubiquitin ligase. A synthetic retinoid, Am80, attenuates Moreover, publicly available data sets showed humans, expression...
Depression is a common psychiatric disorder that affects almost 10% of children and adolescents worldwide. Numerous synthetic chemical antidepressants used to treat depression have adverse side effects. Therefore, new therapeutic approaches for treatment are urgently needed. Leonurus cardiaca has recently been shown be effective the nervous system diseases such as depression, but its mechanism not clear. In this study, we aimed reveal underlying leonurine's antidepressant activity. Leonurine...
Objective: Multiple mechanisms including vascular endothelial cell damage have a critical role in the formation and development of atherosclerosis (AS), but specific molecular are not exactly clarified. This study aims to determine possible roles proline-rich tyrosine kinase 2 (Pyk2)/mitochondrial calcium uniporter (MCU) pathway AS mouse model H O -induced explore its mechanisms. Approach Results: The was established using apolipoprotein E-knockout (ApoE –/– ) mice that were fed with...
To study the involvement and interrelationship of epithelial cell adhesion molecule (EpCAM) epithelial-mesenchymal transition (EMT) in endometriosis.Samples from 114 patients undergoing endometrial biopsy or operation for endometriosis 23 premenopausal women non-endometriotic benign disease. Immunohistochemistry was used to detect expression level EpCAM, E-cadherin N-cadherin endometrium with (n = 24) without 23), lesions bowel 46), peritoneal 20) ovarian endometriosis.There no significant...
The growth rate of bacteria increases under simulated microgravity (SMG) with low-shear force. next-generation microbial chassis Vibrio natriegens (V. ) is a fast-growing gram-negative, non-pathogenic bacterium generation time less than 10 minutes. Screening V. strain faster was attempted by two-week continuous long-term culturing SMG. However, the rapid this made it difficult to obtain desired mutant even more growth. Thus, slower emerged. Multi-omics integration analysis conducted explore...
In the development of oxidative stress-relevant diseases, reactive oxygen species (ROS) removal obstacle or excess production results in damage body tissues and organs. Recent studies have demonstrated that nuclear factor E2-related 2/heme oxygenase-1 (Nrf2/HO-1) axis played a significant role anti-oxidative stress. The Nrf2/HO-1 counteracts stress injury by its resistance to inflammation, oxidation, mitochondrial calcium influx, apoptosis, pyroptosis, ferroptosis autophagy, which provides...
To search for certain signature proteins and the expression profiles in lacrimal passage stenosis,rabbit models of stenosis were treated by 125I seed brachytherapy.All separated two-dimensional electrophoresis,and identified mass spectrometry.The results show that up-regulated are peptidyl-prolyl cis-trans isomerase A(PPIase A),and epidermal fatty acid-binding protein(E-FABP),while down-regulated myosin light chain 1(isomer skeletal muscle),myosin polypeptide 6(isomer 1 smooth muscle...
Background Recent research showed that stromal cell-derived factor-1 (SDF-1) plays critical role in mediating inflammation,metastasis of tumour and neovascularization tumour.However,There is still no report about the effects SDF-1 on alkali-burn-induced corneal (CNV).Objective The aim this study attempts to investigate chemokine receptor CXCR4 alkali-induced mice.Methods Alkali-induced-corneal animal models were constructed 15 eyes clean C57/BL mice by placing filter paper with 1 mol/L NaOH...
Lung alveolar type II cells (AT2) are involved in synthesis, storage and secretion of lung surfactant. Lipid rafts provide unique platforms to organize regulate diverse cellular protein machinery. We have previously shown that lipid essential for surfactant secretion. hence studied the proteomic profile AT2 cell identify proteins were isolated following ice-cold 1% Triton X-100 solubilization sucrose gradient centrifugation. The purified raft fractions separated by 2-dimensional gel...