A5030763978- Ion-surface interactions and analysis
- Bone Metabolism and Diseases
- Fusion materials and technologies
- Magnetic confinement fusion research
- Bone health and treatments
- Nuclear Materials and Properties
- Plasma Diagnostics and Applications
- NF-κB Signaling Pathways
- Heavy Metal Exposure and Toxicity
- Nuclear Physics and Applications
- Astro and Planetary Science
- Solar and Space Plasma Dynamics
- Diamond and Carbon-based Materials Research
- Metal and Thin Film Mechanics
- Laser-induced spectroscopy and plasma
- Immune Response and Inflammation
- Selenium in Biological Systems
- dental development and anomalies
- Biochemical effects in animals
- Erythrocyte Function and Pathophysiology
- Diet and metabolism studies
- Bone and Dental Protein Studies
- Muscle Physiology and Disorders
- TGF-β signaling in diseases
- Planetary Science and Exploration
Okayama University of Science
1998-2024
Tokyo Medical and Dental University
1990-2023
Japan Agency for Medical Research and Development
2017-2020
Institute for Environmental Sciences
2019
The University of Tokyo
1970-2019
University of Tokyo Hospital
2012
Nagoya University
1975-2008
Musashi University
2007
Tokyo Metropolitan University
2002
National Institute for Fusion Science
1992-1994
Abstract Immune responses are crucial not only for host defence against pathogens but also tissue maintenance and repair after injury. Lymphocytes involved in the healing process injury, including bone fracture muscle damage. However, specific immune cell subsets mediators of entirely clear. Here we show that γδ T cells produce IL-17A, which promotes formation facilitates healing. Repair is impaired IL-17A-deficient mice due to a defect osteoblastic formation. IL-17A accelerates by...
The Large Helical Device (LHD) now under construction is a heliotron/torsatron device with closed divertor system. edge LHD magnetic structure has been studied in detail. A peculiar feature of the configuration existence surface layers, complicated three dimensional which does not, however, seem to hamper expected functions. Two operational modes are being considered for experiment-high density, cold radiative operation as safe heat removal scheme and high temperature plasma operation. In...
Mastication is an indispensable oral function related to physical, mental, and social health throughout life. The elderly tend have a masticatory dysfunction due tooth loss fragility in the muscles with aging, potentially resulting impaired cognitive function. Masticatory stimulation has influence on development of central nervous system (CNS) as well growth maxillofacial tissue children. Although relationship between mastication important period, cellular molecular mechanisms not been...
The definitive enzymatic difference between a cancer cell and the normal from which it arose is yet to be established in single instance. Recognizing difficulties inherent study of tumor cells without knowing are their progenitors, we set out find hepatoma that would resemble liver so closely detailed comparisons with justifiable. Ten different strains were studied, one was unique extent resembled liver. Morris 5123 grows slowly, but kills host, invasive, metastasizes. It contains about 30...
Orthodontic tooth movement is achieved by the remodeling of alveolar bone surrounding roots teeth. Upon application orthodontic force, osteoclastic resorption occurs on compression side bone, towards which teeth are driven. However, molecular basis for regulatory mechanisms underlying has not been sufficiently elucidated. Osteoclastogenesis regulated receptor activator nuclear factor-κB ligand (RANKL), postulated to be expressed cells roots. Here, we show that osteocytes critical source...
Bone undergoes a constant reconstruction process of resorption and formation called bone remodeling, so that it can endure mechanical loading. During food ingestion, masticatory muscles generate the required force. The magnitude applied force has long been believed to be closely correlated with shape jawbone. However, both mechanism underlying this correlation evidence causation remain largely determined. Here, we established novel mouse model increased mastication in which mice were fed...
Significance Skeletal muscle atrophy occurs as a result of variety conditions including aging, disuse, and cachexia. In this study, we show that the transcription factor KLF5 is transiently up-regulated by metabolic disuse stimulations plays pivotal role in onset vitro vivo. physically interacts with Foxo1, together, they regulate Fbxo32 , key atrophy-inducing ubiquitin ligase. A synthetic retinoid, Am80, attenuates Moreover, publicly available data sets showed humans, expression...
Orthodontic tooth movement (OTM) is accomplished by controlling the mechanical loading onto bone around roots of target teeth. The precise orthodontic force induces osteoclastic resorption on compression side and osteoblastic formation tension alveolar bone. intervention causes inflammation in periodontal ligament (PDL), which manifests as acute pain. Because deeply connected to remodeling, it has been indicated that after affects both teeth generation However, mechanisms underlying immune...
A rapid polarization control in paraelectric materials is important for an ultrafast optical switching useful the future communication. In this study, we applied terahertz-pump second-harmonic-generation-probe and optical-reflectivity-probe spectroscopies to neutral phase of organic molecular dielectric, tetrathiafulvalene-p-chloranil revealed that a terahertz pulse with electric-field amplitude ∼400 kV/cm produces subpicosecond time scale large macroscopic whose magnitude reaches ∼20%...
Coupling of charge and spin degrees freedom is a critical feature correlated electron oxides, as represented by the spin-related mechanism Cooper pair under high-T c superconductivity. A doublon-holon generated on an antiferromagnetic background also predicted to attract each other via spin-spin interaction J, similar pair, while its evidence difficult obtain experimentally. Here, we investigate such excitonic effect electroreflectance spectroscopy using terahertz electric field pulses in...
The supplementation of royal jelly (RJ) is known to provide a variety health benefits, including anti-inflammatory and anti-obesity effects. RJ treatment also reportedly protects against bone loss, but no single factor in has yet been identified as an anti-osteoporosis agent. Here we fractionated 10-hydroxy-2-decenoic acid (10H2DA) key component involved inhibiting osteoclastogenesis based on mass spectrometric analysis. We further demonstrated free fatty receptor 4 (FFAR4) directly...
Abstract Background Regeneration of injured tissue is dependent on stem/progenitor cells, which can undergo proliferation and maturation processes to replace the lost cells extracellular matrix (ECM). Bone has a higher regenerative capacity than other tissues, with abundant mesenchymal progenitor in bone marrow, periosteum, surrounding muscle. However, treatment fractures not always successful; marked number clinical case reports have described nonunion or delayed healing for various...
Impaired locomotion has been extensively studied worldwide because those afflicted with it have a potential risk of becoming bedridden. Physical exercise at times can be an effective remedy for frailty, but therapy cannot applied in all clinical cases. Medication is safer than exercise, there are no drugs that reinforce both muscle and bone when administered alone. Multiple medications increase the adverse events; thus, need individual targeting tissues. To this end, we established novel...
Measurements on stratospheric aerosols at Syowa Station (69°00′S, 39°35′E) in 1983, 1984 and 1985 are described. The year‐to‐year changes aerosol content were influenced by volcanic eruption of Mt. El Chichon (spring 1982, Mexico) variations temperature. load winter 1983 was about five times larger than the 1985. particle spring that even though effect more severe 1983. This may be a result decrease average temperature spring. If heterogeneous reactions including particles indeed important...
Abstract Henoch–Schönlein purpura (HSP) is a disease that involves palpable on the skin, joint pain, and gastrointestinal problems. An acute bacterial infection one of causes HSP. Odontogenic infectious diseases have also been implicated in causing However, there are only few reports describing correlation between HSP odontogenic diseases. The present study describes case which patient was cured following dental treatment.
Exposure of adipocytes rats to CdCl2 caused acceleration [3-3H]glucose incorporation into lipid maximally at 500 microM in Krebs-Ringer bicarbonate buffer, pH 7.4, containing 0.2% albumin. T.l.c. the lipids extracted from showed that Cd2+ increased labelling di- and tri-[14C]acylglycerols predominantly. With increasing concentrations glucose apparent Km value was not affected by Cd2+, but V increased, similarly effect insulin. In presence insulin, (5 microM) exerted a consistent additive...