A5021188750- PARP inhibition in cancer therapy
- Cell death mechanisms and regulation
- Enzyme-mediated dye degradation
- Tannin, Tannase and Anticancer Activities
- interferon and immune responses
- Lipid Membrane Structure and Behavior
- Fungal Biology and Applications
- Biochemical and biochemical processes
- Lignin and Wood Chemistry
- Minerals Flotation and Separation Techniques
- SARS-CoV-2 and COVID-19 Research
University of Cologne
2022-2024
BOKU University
2021
Cell death coordinates repair programs following pathogen attack and tissue injury. However, aberrant cell can interfere with such cause organ failure. Cellular FLICE-like inhibitory protein (cFLIP) is a crucial regulator of substrate Caspase-8. the physiological role cFLIP cleavage by Caspase-8 remains elusive. Here, we found an essential for in restraining different pathophysiological scenarios. Mice expressing cleavage-resistant mutant,
Abstract Necroptosis is a caspase-independent modality of cell death implicated in many inflammatory pathologies. The execution this pathway requires the formation cytosolic platform that comprises RIPK1 and RIPK3 which, turn, mediates phosphorylation pseudokinase MLKL (S345 mouse). activation executioner followed by its oligomerisation accumulation at plasma-membrane where it leads to via destabilisation consequent permeabilisation. While biochemical cellular characterisation these events...
In the secretome of Phanerochaete chrysosporium, a white-rot fungus serving as model organism to elucidate lignocellulose deconstruction, copper containing metalloprotein glyoxal oxidase (GLOX) is potentially involved in crucial production hydrogen peroxide fuel and initiate oxidative biomass degradation by lignin-degrading peroxidases. Its ability oxidize variety aldehydes α-hydroxy carbonyls with concomitant reduction dioxygen has attracted attention for its application green biocatalyst...
Abstract Cell death coordinates repair programs following pathogen attack and tissue injury. However, aberrant cell can interfere with such cause organ failure. cFLIP is a crucial regulator of substrate Caspase-8. Yet, the physiological role cleavage by Caspase-8 remains elusive. Here, we discovered an essential for in restraining different pathophysiological scenarios. Mice expressing cleavage-resistant mutant, Cflip D377A , exhibited increased sensitivity to SARS-CoV-induced lethality,...