A5036015097- PARP inhibition in cancer therapy
- Cell death mechanisms and regulation
- interferon and immune responses
- Lipid Membrane Structure and Behavior
University of Cologne
2022-2023
Cell death coordinates repair programs following pathogen attack and tissue injury. However, aberrant cell can interfere with such cause organ failure. Cellular FLICE-like inhibitory protein (cFLIP) is a crucial regulator of substrate Caspase-8. the physiological role cFLIP cleavage by Caspase-8 remains elusive. Here, we found an essential for in restraining different pathophysiological scenarios. Mice expressing cleavage-resistant mutant,
Abstract Cell death coordinates repair programs following pathogen attack and tissue injury. However, aberrant cell can interfere with such cause organ failure. cFLIP is a crucial regulator of substrate Caspase-8. Yet, the physiological role cleavage by Caspase-8 remains elusive. Here, we discovered an essential for in restraining different pathophysiological scenarios. Mice expressing cleavage-resistant mutant, Cflip D377A , exhibited increased sensitivity to SARS-CoV-induced lethality,...