A5042058079- Lanthanide and Transition Metal Complexes
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Radiopharmaceutical Chemistry and Applications
- Advanced MRI Techniques and Applications
- Radioactive element chemistry and processing
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
Northwestern University
2023-2024
Oakland University
2017
Boron subphthalocyanines (SPcs) are aromatic macrocycles that possess a combination of physical and optical properties make them excellent candidates for application as fluorescent imaging probes. These molecules have intense electronic absorption emission, structural versatility allows specific tuning properties. Herein, we report the synthesis series low-symmetry fluorinated SPcs compare to analogous compounds with varying numbers peripheral fluorine atoms varied aromaticity. Across...
Diagnostic medical imaging utilizes magnetic resonance (MR) to provide anatomical, functional, and molecular information in a single scan. Nanoparticles are often labeled with Gd(III) complexes amplify the MR signal of contrast agents (CAs) large payloads high proton relaxation efficiencies (relaxivity, r1). This study examined performance two structurally unique cages, AaLS-13 OP, Gd(III). The cages have characteristics relevant for development theranostic platforms, including (i)...
F parashift probes with paramagnetically shifted reporter nuclei provide attractive platforms to develop molecular imaging probes. These enable ratiometric detection of disease markers using a direct technique. Here, we describe series trivalent lanthanide (Ln(III)) complexes that are structural analogues the clinically approved MR contrast agent (CA) ProHance obtain