A5063653940- Parasites and Host Interactions
- Helminth infection and control
- Parasite Biology and Host Interactions
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Protein Structure and Dynamics
- Advanced MRI Techniques and Applications
- Parasitic Diseases Research and Treatment
- Synthesis of heterocyclic compounds
- Biosensors and Analytical Detection
- Enzyme Structure and Function
- HIV Research and Treatment
- Chemical Synthesis and Reactions
- Respiratory viral infections research
- Nanoparticle-Based Drug Delivery
- Biochemical and Structural Characterization
- Porphyrin Metabolism and Disorders
- Biotin and Related Studies
- Force Microscopy Techniques and Applications
- Metal complexes synthesis and properties
- Microbial Natural Products and Biosynthesis
- bioluminescence and chemiluminescence research
- RNA and protein synthesis mechanisms
- Malaria Research and Control
- Iron Metabolism and Disorders
University Hospital of Basel
2024
University of Basel
1964-2024
Swiss Tropical and Public Health Institute
2020-2024
ETH Zurich
2014-2023
University of Würzburg
2014-2022
Max Delbrück Center
2015
ABSTRACT Dengue fever is a severe, widespread, and neglected disease with more than 2 million diagnosed infections per year. The dengue virus NS2B/NS3 protease (PR) represents prime target for rational drug design. At the moment, there are no clinical PR inhibitors (PIs) available. We have identified diaryl (thio)ethers as candidates novel class of PIs. Here, we report selective noncompetitive inhibition serotype 3 in vitro cells by benzothiazole derivatives exhibiting 50% inhibitory...
The purpose of this study was to evaluate the feasibility an eight-channel dual-tuned transceiver surface RF coil array for combined (1)H/(19)F MR human knee at 7.0 T following application (19)F-containing drugs. includes a posterior module with two (1)H loop elements and anterior modules, each consisting one (19)F elements. decoupling neighbor is achieved by shared capacitor. Electromagnetic field simulations were performed afford uniform transmission fields be in accordance safety...
Trichuriasis caused by the human whipworm Trichuris trichiura poses a significant public health concern. Albendazole-ivermectin co-medication is currently most effective treatment. Studies conducted in Tanzania and Côte d'Ivoire unveiled differences efficacy for albendazole-ivermectin combination therapy both countries. A pharmacometrics approach was used to assess study population effects on pharmacokinetics of two main metabolites albendazole. An exploratory exposure-efficacy analysis also...
We investigated the inhibition of protein–protein interactions by nanoESI-MS to monitor extent and binding mechanism.
Background HIV-disease progression correlates with immune activation. Here we investigated whether corticosteroid treatment can attenuate HIV disease in antiretroviral-untreated patients. Methods Double-blind, placebo-controlled randomized clinical trial including 326 HIV-patients a resource-limited setting Tanzania (clinicaltrials.gov NCT01299948). Inclusion criteria were CD4 count above 300 cells/μl, the absence of AIDS-defining symptoms and an ART-naïve therapy status. Study participants...
Moxidectin is a frontrunner drug candidate in the treatment of strongyloidiasis. A dose 8 mg recommended to treat this indication, which shows reasonably good efficacy and tolerability profile. Yet, owing unique life cycle Strongyloides stercoralis (S. stercoralis) that entails internal autoinfection, curative would be desirable. Population-based pharmacometric modeling help identify an ideal dosing strategy are yet lacking. The aims study were (i) explore exposure-efficacy response...
Strongyloides stercoralis is a soil-transmitted helminth affecting an estimated 30–100 million people. Since the infection may be severe and life-threatening, accessible effective treatment pivotal. Currently, ivermectin drug of choice but has limitations. Moxidectin, veterinary anthelminthic approved for use in human onchocerciasis, promising alternative against strongyloidiasis. In this study, we evaluated vitro activity moxidectin on ratti larvae (L3) adult females as well...
Infections with hookworms affect about half a billion people worldwide. Recommended therapy includes 400 mg of albendazole, which is moderately efficacious. Higher doses have been rarely assessed.
Diagnostic medical imaging utilizes magnetic resonance (MR) to provide anatomical, functional, and molecular information in a single scan. Nanoparticles are often labeled with Gd(III) complexes amplify the MR signal of contrast agents (CAs) large payloads high proton relaxation efficiencies (relaxivity, r1). This study examined performance two structurally unique cages, AaLS-13 OP, Gd(III). The cages have characteristics relevant for development theranostic platforms, including (i)...
Moxidectin has recently attracted attention as a novel candidate for the treatment of helminth infections, including Strongyloides stercoralis. This study aims to characterize population pharmacokinetics (PPK) moxidectin in S. stercoralis-infected adults using pharmacometric approach, and perform model-based simulations explore different drug dosing strategies. A PPK embedded dose-escalation phase IIa trial was conducted NamBak, Laos. Eight micro blood samples were collected from each 96...
The homotrimeric ligand tumor necrosis factor α (TNFα) is a key cytokine and immune regulator; however, when deregulated, it leads to several major chronic inflammatory diseases. Perturbation of the protein–protein interface has proven be an efficient strategy inactivate TNFα, but atomic-resolution mechanism its inactivation remains poorly understood. Here, we probe solution structure dynamics active inactive TNFα using NMR spectroscopy. data reveal that undergoes motions on different time...
<ns4:p><ns4:bold>Background: </ns4:bold>Infections with soil-transmitted helminths (STHs) predominantly affect impoverished populations in tropical environments. The periodic administration of single dose benzimidazoles (i.e., albendazole, mebendazole) to at-risk individuals endemic regions is at the center STH control strategies. Given low efficacy these drugs against trichuriasis, investigation drug combinations including moxidectin and ivermectin has recently been initiated, yet...
Albendazole is the most commonly used drug in preventive chemotherapy programmes against soil-transmitted helminth (STH) infections, with standard dose of 400 mg resulting suboptimal clinical outcomes. Population pharmacokinetic (PK) models that could inform dosing strategies are not yet available.A population model was developed based on micro-blood samples collected from 252 patients aged 2 to 65 years, infected either hookworm or Trichuris trichiura and treated albendazole doses ranging...
Abstract The efficacy of the combination therapy albendazole and ivermectin against Trichuris trichiura infection is higher in Tanzania than Côte d'Ivoire. This study therefore aimed to investigate difference between population pharmacokinetics (PK) at these sites determine if an exposure‐response analysis could explain low Twenty‐four participants (aged 12‐19 years) receiving single doses (200 µg/kg) (400 mg) were included PK modeling. A regression was performed relationship reduction fecal...
Abstract: Six years ago 4 patients suffering from myasthenia gravis (MG) types C and E according to Compston with failed drug therapy were initially treated 3 times (1 patient, a total of 11 times) by protein A immunoadsorption (Immunosorba, Excorim AB, Lund, Sweden). No further treatments have been carried out. In addition, given thymectomy. The present status the was checked. We could see beneficial effect in all MG patients. are fit for work; each has an improved Besinger index. used as...