A5086828679- Computational Drug Discovery Methods
- Telomeres, Telomerase, and Senescence
- Neurogenesis and neuroplasticity mechanisms
- Melanoma and MAPK Pathways
- Advanced Proteomics Techniques and Applications
- Zebrafish Biomedical Research Applications
- Toxoplasma gondii Research Studies
- Hematopoietic Stem Cell Transplantation
- Autophagy in Disease and Therapy
- Enzyme Structure and Function
- Ubiquitin and proteasome pathways
Sorbonne Paris Cité
2024
Laboratoire de Biologie du Développement
2024
Sorbonne Université
2024
Institute for Research in Biomedicine
2019-2023
Abstract Apoptosis and senescence are two mutually exclusive cell fate programs that can be activated by stress. The factors instruct cells to enter into or apoptosis not fully understood, but both regulated the stress kinase p38α. Using an inducible system specifically activates this pathway, we show sustained p38α activation suffices trigger massive autophagosome formation enhance basal autophagic flux. This requires concurrent effect of increased mitochondrial reactive oxygen species...
ABSTRACT The first hematopoietic stem and progenitor cells (HSPCs) emerge in the Aorta-Gonad-Mesonephros (AGM) region of mid-gestation mouse embryo. However, precise nature their supportive mesenchymal microenvironment remains largely unexplored. Here, we profiled transcriptomes laser micro-dissected aortic tissues at three developmental stages individual AGM cells. Computational analyses allowed identification several cell subpopulations within E11.5 mesenchyme, with presence a yet...
p38α (encoded by MAPK14) is a protein kinase that regulates cellular responses to almost all types of environmental and intracellular stresses. Upon activation, phosphorylates many substrates both in the cytoplasm nucleus, allowing this pathway regulate wide variety processes. While role stress response has been widely investigated, its implication cell homeostasis less understood. To investigate signaling networks regulated proliferating cancer cells, we performed quantitative proteomic...
Abstract p38α (encoded by MAPK14 ) is a protein kinase that regulates cellular responses to almost all types of environmental and intracellular stresses. Upon activation, phosphorylates many substrates both in the cytoplasm nucleus, allowing this pathway regulate wide variety processes. While role stress response has been widely investigated, its implication cell homeostasis less understood. To investigate signaling networks regulated normally proliferating cancer cells, we performed...