- Hematopoietic Stem Cell Transplantation
- Neurogenesis and neuroplasticity mechanisms
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Zebrafish Biomedical Research Applications
Laboratoire de Biologie du Développement
2024
Sorbonne Université
2024
Sorbonne Paris Cité
2024
ABSTRACT The first hematopoietic stem and progenitor cells (HSPCs) emerge in the Aorta-Gonad-Mesonephros (AGM) region of mid-gestation mouse embryo. However, precise nature their supportive mesenchymal microenvironment remains largely unexplored. Here, we profiled transcriptomes laser micro-dissected aortic tissues at three developmental stages individual AGM cells. Computational analyses allowed identification several cell subpopulations within E11.5 mesenchyme, with presence a yet...