A5074307769- Platelet Disorders and Treatments
- Blood groups and transfusion
- Cardiac Valve Diseases and Treatments
- Immunodeficiency and Autoimmune Disorders
- Electrospun Nanofibers in Biomedical Applications
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Additive Manufacturing and 3D Printing Technologies
- Hemophilia Treatment and Research
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing Materials and Processes
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Elasticity and Material Modeling
- Chronic Lymphocytic Leukemia Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Biomedical and Engineering Education
- Engineering Education and Pedagogy
- Parental Involvement in Education
- Atrial Fibrillation Management and Outcomes
- Pharmacological Effects and Toxicity Studies
- Engineering Education and Curriculum Development
- Cardiac, Anesthesia and Surgical Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
University of Pittsburgh
2007-2023
Karolinska University Hospital
2015-2023
Karolinska Institutet
2015-2023
Sanquin
2017-2023
University of Amsterdam
2017-2023
Amsterdam University Medical Centers
2018-2023
University of North Carolina at Charlotte
2020
Clarkson University
2020
Swanson Center
2018
University Medical Center Utrecht
2014-2017
To provide evidence of whether seizure clustering is associated with drug resistance and increased mortality in childhood-onset epilepsy, a prospective, long-term population-based study was performed. One hundred twenty patients who had been followed since disease onset (average age 37.0 years, SD 7.1, median 40.0, range 11–42; incident cases) were included. At the end follow-up period, 26 (11 boys) these (22%) recorded clusters seizures. Fourteen pre-treatment clusters, including 10 as...
IgG antibodies are important mediators of vaccine-induced immunity through complement- and Fc receptor-dependent effector functions. Both influenced by the composition conserved N-linked glycan located in domain. Here, we compared anti-Spike (S) IgG1 glycosylation profiles response to mRNA, adenoviral, protein-based COVID-19 vaccines mass spectrometry (MS). All induced a transient increase antigen-specific galactosylation sialylation. An initial, afucosylated was membrane-encoding S protein...
Introduction Rotational thromboelastometry ( ROTEM ® ) and thromboelastography TEG are increasingly used in the perioperative emergency assessment of bleeding tendencies. The diagnostic value for von Willebrand disease VWD remains to be established. Aim To investigate whether can discriminate patients with from healthy controls. Methods whole blood coagulation profiles were compared between n = 100) controls 89). Measures accuracy calculated, including sensitivity, specificity receiver...
The urinary bladder wall (UBW), which is composed of smooth muscle, collagen, and elastin, undergoes profound remodeling in response to changes mechanical loading resulting from various pathologies. In our laboratory, we have observed the production fibrillar elastin extracellular matrix (ECM), makes UBW a particularly attractive tissue investigate muscle remodeling. present study, explored role that de novo fibers play altering ECM behavior using structural constitutive modeling approach....
High titers of HLA antibodies are associated with platelet refractoriness, causing poor increments after transfusions in a subset patients antibodies. Currently, we do not know the biological mechanisms that explain variability clinical responses alloimmunized receiving transfusions. Previously showed anti-HLA IgG-antibodies induces FcγRIIa-dependent activation and enhanced phagocytosis. Here, investigated whether IgG can induce complement on platelets. We found induced via classical...
Essentials There is a need for improved tools to predict persistent and chronic immune thrombocytopenia (ITP). We developed validated clinical prediction model recovery from newly diagnosed ITP. The Childhood ITP Recovery Score predicts transient vs. response intravenous immunoglobulins. score may serve as useful tool clinicians individualize patient care. ABSTRACT: Background (ITP) an autoimmune bleeding disorder. prognosis (transient, persistent, or ITP) remains difficult predict....
MyChart is one of the new, innovative features Kaiser Permanente (KP) HealthConnect—the comprehensive, integrated, organizational, and personal electronic health medical record. MyChart, an Epic Systems Corporation (Verona, WI) product, a secure member Web site where registered patients can view portions their record, exchange messages with primary care physician (PCP) other recently visited clinicians. The KP Northwest (KPNW) Region, in Portland, Oregon, was first Region to implement...
In childhood immune thrombocytopenia (ITP), anti-platelet autoantibodies mediate platelet clearance through Fc-γ receptor (FcγR)-bearing phagocytes. 75% to 90% of patients, the disease has a transient, self-limiting character. Here we characterized how polymorphisms FcγR genes affect susceptibility, response intravenous immunoglobulin (IVIg) treatment, and long-term recovery from ITP. Genotyping FCGR2/3 locus was performed in 180 children with newly diagnosed ITP, 22 chronic healthy control...
Abstract The interactions of antibodies with myeloid Fcγ receptors and the complement system are regulated by an Asn297-linked glycan in Fc portion IgG. Alterations serum IgG-Fc glycosylation have been reported various autoimmune diseases, correlate treatment response disease activity. We hypothesized that is altered immune thrombocytopenia (ITP) associates to anti-CD20 monoclonal antibody (rituximab). was analyzed liquid chromatography-mass spectrometry. found identical between refractory...
Summary Von Willebrand disease (VWD) is the most common bleeding disorder, but no bedside tests specific for factor are available. The objective of this study was to evaluate diagnostic accuracy whole blood ristocetin-induced platelet aggregometry (WB-RIPA) in VWD. WB-RIPA performed VWD patients (n=100) and healthy controls (n=17) using Multiplate® impedance platform. properties test were described as sensitivity/specificity, positive negative predictive value, ROC area under curve (AUC)....
CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 linked the extent of artery disease (CAD) prognostic for primary events follow-up.We measured serum concentrations 712 patients chest discomfort referred cardiac CT angiography. Obstructive CAD was defined as ≥50 % stenosis. The by calcium score segment (number segments any CAD, range 0-16)....
Background Anti-platelet antibody testing may be useful for the diagnosis and management of childhood immune thrombocytopenia (ITP). Objectives Here we aimed to assess prevalence prognostic significance anti-platelet glycoprotein-specific IgM IgG antibodies. Methods Children with newly diagnosed ITP were included at randomized an intravenous immunoglobulins (IVIg) or careful observation group (TIKI trial). In this well-defined longitudinally followed cohort (N = 179), antibodies determined...
Patients with type 3 von Willebrand disease (VWD-3) have no measurable levels of VW factor (VWF) and usually require treatment VWF-FVIII concentrate to prevent and/or stop bleeding. Even though the patients are treated prophylactically, they may experience bleeding symptoms. The aim this study was evaluate effect in VWD-3 Total Thrombus Analysis System (T-TAS®), which measures thrombus formation under flow conditions. Coagulation profiles 10 were analysed using T-TAS before 30 minutes after...