- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- dental development and anomalies
- Orthodontics and Dentofacial Orthopedics
- Dental Radiography and Imaging
- Solar and Space Plasma Dynamics
- Endodontics and Root Canal Treatments
- Temporomandibular Joint Disorders
- Stellar, planetary, and galactic studies
- Solar Radiation and Photovoltaics
- Geophysics and Gravity Measurements
- Tracheal and airway disorders
- Anatomy and Medical Technology
- 3D Shape Modeling and Analysis
- Adaptive optics and wavefront sensing
- Medical Image Segmentation Techniques
- Morphological variations and asymmetry
- Prenatal Screening and Diagnostics
- Ocular Disorders and Treatments
- Augmented Reality Applications
- Statistical and numerical algorithms
- Scoliosis diagnosis and treatment
- Shoulder Injury and Treatment
- Facial Trauma and Fracture Management
- Osteoarthritis Treatment and Mechanisms
Technical University of Denmark
2010-2023
Rigshospitalet
2009-2023
Copenhagen University Hospital
2011-2023
University of Copenhagen
2012-2023
National Medical Research Center of Dentistry and Maxillofacial Surgery
2018
Centre for Sight
2018
Capital Region of Denmark
2011
IT University of Copenhagen
2010
Washington University in St. Louis
2006
University of Oxford
2006
The aim of this study was to perform a qualitative analysis the relationship between external and internal macromorphology root complex use fractal dimension determine correlation shape outer surface canal.On basis X-ray computed transaxial microtomography, quantitative in permanent maxillary molars performed using well-defined macromorphological variables analysis. Five were placed microfocus tube with focal spot size 0.07 mm, Thomson-SCF image intensifier, CCD camera compromising detector...
This study examines cellular and microradiographic findings in thin, undemineralized sections of 46 cavitated lesions, that were clinically well–defined with respect to lesion activity estimated age at extraction time. The progressive stages surface breakdown ranged from enamel cavitation larger dentine exposures classified as closed open environments. Measurements the following parameters performed using computerized image processing software: (a) cytoplasm:nucleus ratio primary odontoblast...
Objective: To characterize the craniofacial phenotype of a mouse model for Crouzon syndrome by quantitative analysis skull morphology in mutant and wild-type mice to compare findings with features observed humans syndrome. Methods: MicroCT scans skeletal preparations were obtained on previously described Fgfr2 C342Y/+ at 6 weeks age. Three-dimensional coordinate data from biologically relevant landmarks skulls collected. Euclidean Distance Matrix Analysis was used quantify shapes using these...
Markvart M, Darvann TA, Larsen P, Dalstra Kreiborg S, Bjørndal L. Micro‐CT analyses of apical enlargement and molar root canal complexity. International Endodontic Journal , 45 273–281, 2012. Abstract Aim To compare the effectiveness two rotary hybrid instrumentation techniques with focus on in teeth to quantify visualize spatial details efficacy canals different Methodology Maxillary mandibular were scanned using X‐ray microcomputed tomography. Root prepared either a GT/Profile protocol or...
This study describes cellular and microradiographic findings in thin undemineralized enamel-dentine sections from 36 enamel caries lesions freshly extracted third molars. Lesions activity was determined by clinical examination the estimated age of lesion at extraction time. The reactions to enamel/dentine complex were measured using computerized histomorphometry under following conditions: (a) cytoplasm:nucleus ratio odontoblast cell; (b) cell:dentinal tubule ratio, (c) adjacent predentine...
The echogenicity patterns of ultrasound scans contain information tissue composition in muscles. aim was: (1) to develop a quantitative image analysis characterize terms intensity and structure the images, (2) use method for characterization images supraspinatus muscle, vastus lateralis muscle.Computerized texture analyses employing first-order higher-order grey-scale statistics were developed objectively m. from 9 healthy participants.The mean was higher muscle (p < 0.05) than (average...
Objective Analysis of early postnatal mandibular size and growth velocity in children with untreated isolated cleft palate (ICP), nonsyndromic Robin sequence (RS), a control group unilateral incomplete lip (UICL). Material 114 (66 palate, 7 sequence, 41 lip) drawn from representing all Danish born 1976 through 1981. All were examined at both 2 22 months age. Methods Cephalometric x-rays maxillary plaster casts. Mandibular length height measured (mm/year) was calculated. Cleft width on the...
Background: Restoring craniofacial symmetry is an important objective in the treatment of many conditions. Normal form has been measured using anthropometry, cephalometry, and photography, yet all these modalities have drawbacks. In this study, authors define normal pediatric asymmetry stereophotogrammetric images, which capture a densely sampled set points on form. Methods: After institutional review board approval, normal, healthy children ( n = 533) with no known abnormalities were...
Objective Analysis of craniofacial morphology and growth in children with untreated isolated cleft palate (ICP) (cleft the secondary only) at 2 22 months age comparison to that a control group unilateral incomplete lip (UICL). Material Methods A total 98 (53 ICP 45 UICL) drawn from larger representing all Danish born period 1976 1981 were included study. Craniofacial analyzed using three-projection infant cephalometry. Results The differed significantly UICL group. most striking findings...
Analysis of craniofacial morphology and growth in children with bilateral complete cleft lip palate (BCCLP), compared a control group unilateral incomplete (UICL), before any treatment as well 20 months after closure.The were drawn from representing all Danish born 1976 to 1981. Sixty-four included the study (19 BCCLP 45 UICL). The ages 2 22 at examinations 1 2, respectively.The method investigation was infant cephalometry three projections. analyzed using linear, angular, area variables....
Abstract OBJECTIVE Crouzon syndrome is caused by mutations in FGFR2 leading to constitutive activation of receptors the absence ligand binding. The characterized premature fusion cranial sutures that leads abnormal skull shape, restricted brain growth, and increased intracranial pressure. Surgical remodeling vault currently used treat affected infants. purpose this study was develop a pharmacologic strategy using tyrosine kinase inhibition as novel treatment for craniosynostotic syndromes...
High-fidelity computer-based modeling, simulation and visualization systems for the study of temporal bone anatomy training middle ear surgery are based on a sequence digital anatomical images, which must cover large tissue volume yet display details in high resolution with fidelity. However, use existing image libraries by independent developers virtual models is limited copyright protection low resolution. A fresh frozen human was CT-scanned serially sectioned at 25 µm images block surface...
Comparison of early craniofacial morphology and growth in children with nonsyndromic Robin Sequence (RS), isolated cleft palate (ICP), unilateral complete lip (UCCLP).One hundred eight cleft: 7 RS, 53 ICP, 48 UCCLP were included the study. The drawn from group all Danish born 1976 through 1981.Three-projection infant cephalometry.The groups had some common characteristics: a wide maxilla decreased length posterior height, nasal cavity, short mandible, bimaxillary retrognathia, reduced...
Quantitatively assess 3D spatially detailed soft-tissue facial asymmetry in children who had undergone craniofacial reconstruction for Unicoronal Synostosis (UCS), and compare the to control patients. It was hypothesized that there would be no significant differences between groups.Clinical, retrospective follow-up study. Methodological study.Primary care center.Twenty-two with UCS were selected after review of records.isolated UCS; surgically treated within first 19 months life, without...
Abstract Purpose: Craniofacial morphology and growth comparisons in children with untreated nonsyndromic Robin Sequence (RS) a control group unilateral incomplete cleft lip (UICL) which the was surgically closed at 2 months of age. Material: The 52 (7 RS 45 UICL) included study were drawn from representing all Danish born 1976 through 1981. ages 22 time examination 1 2, respectively. Method: method investigation three-projection cephalometry. analyzed by means linear, angular, area...
Objective. To investigate and compare facial asymmetry in subjects with JIA unilateral, bilateral or no TM joint (TMJ) involvement. Methods. Eighty-one JIA: 22 unilateral TMJ involvement (Group 1), 15 2) 44 3). Panoramic X-rays three-dimensional (3D) photographs (surface scans) were obtained for all subjects. rated severity of For each individual, a spatially detailed map was created from the 3D photograph. Mean variability calculated three groups compared. Results. Distinct patterns found...
Abstract Crouzon syndrome is characterized by premature fusion of sutures and synchondroses. Recently, the first mouse model was generated, having mutation Cys342Tyr in Fgfr2c , equivalent to most common human Crouzon/Pfeiffer mutation. In this study, a set micro‐computed tomography (CT) scannings skulls wild‐type mice were analysed with respect dysmorphology caused syndrome. A computational craniofacial atlas built automatically from micro‐CT volumes using (1) affine (2) non‐rigid image...
To investigate parental age in relation to the severity of cleft diagnosis a population-based consecutive sample individuals with clefts.Retrospective, consecutive.The comprised 545 cases nonsyndromic clefts (437 lip with/without palate [CL ± P] and 106 isolated [CP]) ages recorded. The groups were subdivided according extent/severity cleft. Unilateral divided left/right sidedness. Logistic regression was used analyse association between risk severe separately for CL P CP, as well...