A5102983562- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Phytochemical Studies and Bioactivities
- Garlic and Onion Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Bioactive natural compounds
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Toxin Mechanisms and Immunotoxins
- Herbal Medicine Research Studies
- Phytochemistry and biological activity of medicinal plants
- Immune Cell Function and Interaction
- Biological Activity of Diterpenoids and Biflavonoids
- Food Quality and Safety Studies
- Organic and Inorganic Chemical Reactions
- Eicosanoids and Hypertension Pharmacology
- Medicinal Plants and Neuroprotection
- Cancer Treatment and Pharmacology
- Heme Oxygenase-1 and Carbon Monoxide
- Skin Protection and Aging
- Genomics, phytochemicals, and oxidative stress
- Silymarin and Mushroom Poisoning
- Medicinal plant effects and applications
- Chemical synthesis and alkaloids
- Sesquiterpenes and Asteraceae Studies
National Development Institute of Korean Medicine
2016-2024
Sungkyunkwan University
2011-2017
Kwangshin University
2013-2014
University of Minnesota
1974
The emergence of immune checkpoint inhibitors, a novel class immunotherapy drugs, represents major breakthrough in cancer immunotherapy, substantially improving patient survival post-treatment. Blocking programmed death-ligand 1 (PD-L1) and death protein-1 (PD-1) has demonstrated promising clinical results various human types. US FDA recently permitted only monoclonal antibody (mAb)-based PD-L1 or PD-1 blockers. Although these antibodies exhibit high antitumor efficacy, their size-...
Achillea alpina is widely distributed in Korea and often used as a folk medicine for stomach disorders. Although previous study isolated antioxidant compounds (flavonoid O-glucoside, sesquiterpene) from this plant, no systematic of its chemical constituents had been reported. The present aimed to identify the phytochemicals methanol extract A. alpina, assess their potential activities vitro, determine effects on melanogenesis B16F10 melanoma cells. Column chromatographic separation aqueous...
Eleven compounds (1–11) were isolated from the rhizomes of Osmunda japonica, and their structures elucidated based on1H,13C-NMR LC-IT-TOF MS data. Of these compounds, all (1 – 11) have been previously reported, although five (6 9, not this plant. The antioxidant activities measured by DPPH ABTS assays, compound 10 showed high activity.
Stachys sieboldii MIQ. (Labiatae) is native to Northern China and widely distributed in North America, Asia, Europe. S. has been used Chinese folk medicine for the treatment of ischemic stroke, senile dementia, various gastrointestinal problems. Previous phytochemical pharmacological studies on this plant reported isolation terpenes, flavonoids, phenolic compounds, it having antimicrobial, antioxidant, antitumor activities. In our continuing efforts study secondary metabolites natural...
A Hyeon Kim, Ji Hun Jang, Kyeong Wan Woo, Jong Eel Park, Ki Ho Lee, Kyung Jung, Byeongkwan An, Won Seok Seong Ham, and Hyun Woo Cho. JABC 2018;61:39-46. https://doi.org/10.3839/jabc.2018.006
Nelumbo nucifera Gaertn. (lotus) is an important medicinal plant, and many parts of the plant have been investigated for their therapeutic effects. However, effect receptacles lotuses on pathological cardiomyocyte hypertrophy has not yet. Therefore, current study aimed to determine protective lotus against angiotensin II (Ang II)-induced in vitro. Ang was used induce H9c2 cells. The receptacle powder (MeOH extract receptaculum Nelumbinis; MRN) experiments prepared by MeOH extraction...
Phytochemical investigation of the methanol extract aerial parts Iris minutiaurea (Iridaceae) using column chromatography led to isolation a new xanthone glycoside, 1-hydroxy-3,5-dimethoxy-xanthone-6-O-β-D-glucoside (1), together with one known flavonoid glycoside (2). The structure this compound was elucidated by analysis spectroscopic, including 1D (1H, 13C), 2D NMR (COSY, HMQC, HMBC), and high resolution fast atom bombardment mass spectrometric (HR-FAB-MS) data enzyme hydrolysis. We found...
This study examined the effects of intrathecal areca nut on spinal nerve-ligated and chemotherapy-induced neuropathic pain (NP), investigated relevance 5-hydroxytryptamine (5-HT) α2-adrenergic receptors to those effects. For drug administration, catheters were inserted into subarachnoid space male Sprague-Dawley rats. NP was induced either by nerve ligation (left nerves L5 L6) or chemotherapeutic injection (intraperitoneal cisplatin, 2 mg/kg/day, once daily for 4 days). Paw withdrawal...
Department of Korean Medicine, Dongguk University, Gyeongju-si, Gyeongbuk 780-714, KoreaReceived December 13, 2012, Accepted February 27, 2013Key Words : Fritillaria thunbergii , Liliaceae, ent-kaurane diterpenoidFritillaria (Liliaceae) is a perennial herb that iswidely distributed in mountainous regions northeastAsia.
Abstract [isolation, structure determination and antineuroinflammatory activities of new Stavonoid glycosides, i.
Abstract isolation and structure elucidation of a new triterpene saponin, Sieboldii saponin A (I), along with five known compounds