A5015072505- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Neonatal Health and Biochemistry
- Hemoglobin structure and function
- Heme Oxygenase-1 and Carbon Monoxide
- Antimicrobial Resistance in Staphylococcus
- Biochemical Acid Research Studies
- Herbal Medicine Research Studies
- Microbial metabolism and enzyme function
- Peptidase Inhibition and Analysis
- Enzyme Structure and Function
- Toxin Mechanisms and Immunotoxins
- Protein Structure and Dynamics
- Bacteriophages and microbial interactions
- Alzheimer's disease research and treatments
- Protein Degradation and Inhibitors
- Microbial Metabolites in Food Biotechnology
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Cholinesterase and Neurodegenerative Diseases
- Microbial Metabolism and Applications
Daegu-Gyeongbuk Medical Innovation Foundation
2021-2024
Korea Basic Science Institute
2013-2018
Korea University of Science and Technology
2013-2018
Quorum sensing (QS), a bacterial process that regulates population-scale behavior, is mediated by small signaling molecules, called autoinducers (AIs), are secreted and perceived, modulating "collective" phenotype. Because the autoinducer AI-2 wide variety of species, its "perception" cues behavior. This response
The emergence of immune checkpoint inhibitors, a novel class immunotherapy drugs, represents major breakthrough in cancer immunotherapy, substantially improving patient survival post-treatment. Blocking programmed death-ligand 1 (PD-L1) and death protein-1 (PD-1) has demonstrated promising clinical results various human types. US FDA recently permitted only monoclonal antibody (mAb)-based PD-L1 or PD-1 blockers. Although these antibodies exhibit high antitumor efficacy, their size-...
Quorum sensing (QS) is a cell-to-cell communication system responsible for variety of bacterial phenotypes including virulence and biofilm formation. QS mediated by small molecules, autoinducers (AIs), AI-2 that secreted both Gram-positive -negative microbes. LsrR key transcriptional regulator governs the varied downstream processes perceiving signal, but its activation via autoinducer-binding remains poorly understood. Here, we provide detailed regulatory mechanism from crystal structures...
Biliverdin IXβ reductase B (BLVRB) has recently been proposed as a novel therapeutic target for thrombocytopenia through its reactive oxygen species (ROS)-associated mechanism. Thus, we aim at repurposing drugs new inhibitors of BLVRB. Based on IC50 (<5 μM), have identified 20 compounds out 1496 from the Food and Drug Administration (FDA)-approved library clearly mapped their binding sites to active site. Furthermore, show detailed BLVRB-binding modes thermodynamic properties (ΔH, ΔS, KD)...
Biliverdin IXβ reductase (BLVRB) has emerged as a promising therapeutic target for thrombocytopenia due to its involvement in reactive oxygen species (ROS) mechanisms. During the pursuit of inhibitors targeting BLVRB, olsalazine (OSA) became apparent one most potent candidates. However, direct application OSA BLVRB inhibitor faces challenges, it is prone degradation into 5-aminosalicylic acid through cleavage diazenyl bond by abundant azoreductase (AzoR) enzymes gut microbiota and eukaryotic...
Quorum sensing (QS) is a cell-to-cell communication system and responsible for variety of bacterial phenotypes including virulence biofilm formation. QS mediated by small molecules, autoinducers (AIs), AI-2 that secreted both Gram (+/–) microbes. LsrR key transcriptional regulator governs the varied downstream processes perceiving signal, but its activation via autoinducer-binding remains poorly understood [1]. The ligand-free crystals complex C-LsrR with 5 mM R5P were grown reservoir...