A5056493219- Protein Tyrosine Phosphatases
- ATP Synthase and ATPases Research
- Galectins and Cancer Biology
- Peptidase Inhibition and Analysis
- Microbial Natural Products and Biosynthesis
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Organic Electronics and Photovoltaics
- Crystallization and Solubility Studies
- Seaweed-derived Bioactive Compounds
- Herpesvirus Infections and Treatments
- Neonatal Health and Biochemistry
- Heme Oxygenase-1 and Carbon Monoxide
- Radiomics and Machine Learning in Medical Imaging
- Enzyme Production and Characterization
- Pharmaceutical and Antibiotic Environmental Impacts
- X-ray Diffraction in Crystallography
- Chemical Analysis and Environmental Impact
- Molecular Junctions and Nanostructures
- Virus-based gene therapy research
- Chemical Reactions and Isotopes
- Computational Drug Discovery Methods
- Hemoglobin structure and function
- Polysaccharides Composition and Applications
- Synthesis and Properties of Aromatic Compounds
University of Louisville
2018-2024
Georgia Southern University
2023-2024
Ateneo de Manila University
2022
Institute of Chemistry, Academia Sinica
2016
Abstract Protein tyrosine phosphatase 4A3 (PTP4A3 or PRL-3) is highly expressed in a variety of cancers, where it promotes tumor cell migration and metastasis leading to poor prognosis. Despite its clinical significance, small molecule inhibitors PRL-3 are lacking. Here, we screened 1443 FDA-approved drugs for their ability inhibit the activity PRL family. We identified five specific as well one selective inhibitor PRL-2. Additionally, found nine that broadly significantly suppressed...
2,3,9,10-Substituted pentacene tetraesters and diester-dinitriles were synthesized. These derivatives underwent an unusual solid state [4 + 4] thermal dimerization with good efficiency complete stereoselectivity. This observation indicates this series of adopt π–π stacking geometry large mutual overlap in state. notion was confirmed by molecualr dynamic simulation.
Protein tyrosine phosphatases (PTP) have emerged as targets in diseases characterized by aberrant phosphorylations such cancers. The activity of the phosphatase regenerating liver 3, PRL3, has been linked to several oncogenic and metastatic pathways, particularly breast, ovarian, colorectal, blood Development small molecules that directly target however, challenging. This is partly due lack structural information on how PRL3 interacts with its inhibitors. Here, computational methods are used...
Biliverdin IXβ reductase (BLVRB) has emerged as a promising therapeutic target for thrombocytopenia due to its involvement in reactive oxygen species (ROS) mechanisms. During the pursuit of inhibitors targeting BLVRB, olsalazine (OSA) became apparent one most potent candidates. However, direct application OSA BLVRB inhibitor faces challenges, it is prone degradation into 5-aminosalicylic acid through cleavage diazenyl bond by abundant azoreductase (AzoR) enzymes gut microbiota and eukaryotic...
ABSTRACT Protein tyrosine phosphatase 4A3 (PTP4A3 or PRL-3) is highly expressed in a variety of cancers, where it promotes tumor cell migration and metastasis leading to poor prognosis. Despite its clinical significance, there are currently no viable options target PRL-3 vivo . Here, we screened 1,443 FDA-approved drugs for their ability inhibit the activity PRL family. We identified five specific inhibitors as well one selective inhibitor PRL-2. Additionally, found nine that broadly...
Abstract Due to their active roles in regulating phosphorylations, protein tyrosine phosphatases (PTP) have emerged as attractive targets diseases characterized by aberrant phosphorylations such cancers. The activity of the phosphatase regenerating liver 3, PRL3, has been linked several oncogenic and metastatic pathways, particularly breast, ovarian, colorectal, blood Development small molecules that directly target however, challenging. This is partly due lack structural information on how...
Carrageenan gelation is characterized by a coil-to-helix transition. The conformation the polymer adopts in solution, however, not yet fully understood at molecular level. Here, dynamics (MD) simulations were carried out on two possible conformations of ι-carrageenan hexamers – single helix and double helix. All-atom using Carbohydrate Solution Force Field (CSFF) explicit water (SPC). Dihedral angle distributions from individual chains compared revealing similarity between these...