Chemicals identified as endocrine-disrupting compounds (EDCs) have widespread consumer uses, yet little is known about indoor exposure. We sampled air and dust in 120 homes, analyzing for 89 organic chemicals EDCs. Fifty-two were detected 66 dust. These are the first reported measures residential environments over 30 of compounds, including several at highest concentrations. The number per home ranged from 13 to 28 6 42 most abundant included phthalates (plasticizers, emulsifiers),...

Background: Bisphenol A (BPA) and bis(2-ethylhexyl) phthalate (DEHP) are high-production-volume chemicals used in plastics resins for food packaging. They have been associated with endocrine disruption animals some human studies. Human exposure sources estimated, but the relative contribution of dietary to total intake has not studied empirically.Objectives: To evaluate packaging exposure, we measured urinary BPA metabolites before, during, after a "fresh foods" intervention.Methods: We...

Higher house dust levels of PBDE flame retardants (FRs) have been reported in California than other parts the world, due to state's furniture flammability standard. However, changing these and FRs not evaluated following 2004 U.S. phase-out PentaBDE OctaBDE. We analyzed collected 16 homes 2006 again 2011 for 62 organohalogens, which represents broadest investigation homes. Fifty-five compounds were detected at least one sample; 41 50% samples. Concentrations chlorinated OPFRs, including two...

Background: Laboratory and human studies raise concerns about endocrine disruption asthma resulting from exposure to chemicals in consumer products. Limited labeling or testing information is available evaluate products as sources.Objectives: We analytically quantified disruptors asthma-related a range of cosmetics, personal care products, cleaners, sunscreens, vinyl also evaluated whether product labels provide that can be used select without these chemicals.Methods: selected 213 commercial...

Approximately 40% of U.S. residents rely on groundwater as a source drinking water. Groundwater, especially unconfined sand and gravel aquifers, is vulnerable to contamination from septic systems infiltration wastewater treatment plant effluent. In this study, we characterized concentrations pharmaceuticals, perfluorosurfactants, other organic compounds (OWCs) in the aquifer Cape Cod, Massachusetts, USA, where are prevalent. Raw water samples 20 public supply wells Cod were tested for 92...

Chemicals that induce mammary tumors in rodents or activate estrogen progesterone signaling are likely to increase breast cancer (BC) risk. Identifying chemicals with these activities can prompt steps protect human health.

As part of a larger effort to characterize the impacts Cape Cod drinking water supplies from on-site wastewater disposal, we developed two analytical methods using HPLC and GC/MS for range compounds identified as endocrine-disrupting chemicals (EDCs), including nonionic surfactants alkylphenol polyethoxylates (APEOs) their degradation products. We analyzed samples nonylphenol, octylphenol, ethoxylates up hexaethoxylate an method, with detection limits ranging 2 6 μg/L. A set phenolic...

Studies show higher house dust and body burden levels of PBDE flame retardants in North America than Europe; but little is known about exposure variation within America, where California's furniture flammability standard affects use. We compared samples from 49 homes two California communities with 120 Massachusetts other published studies. Dust concentrations [median (range) ng/g] BDE-47, -99, -100 were 2700 (112-107 000), 3800 (102-170 684 (<MRL-30 900), respectively, 4−10 times previously...

Interest in the health effects of potential endocrine-disrupting compounds (EDCs) that are high production volume chemicals used consumer products has made exposure assessment and source identification a priority. We collected paired indoor outdoor air samples 40 nonsmoking homes urban, industrial Richmond, CA, 10 rural Bolinas, CA. Samples were analyzed by GC-MS for 104 analytes, including phthalates (11), alkylphenols (3), parabens polybrominated diphenyl ether (PBDE) flame retardants...

Phosphate flame retardants (PFRs) are abundant and found at the highest concentrations relative to other retardant chemicals in house dust; however, little is known about biological levels of PFRs their relationship with dust concentrations. These relationships provide insight into major exposure pathways potential health risks. We analyzed urine samples from 16 California residents 2011 for 6 chlorinated nonchlorinated dialkyl or diaryl phosphates (DAPs), expected metabolites most prominent...

Personal care products are a source of exposure to endocrine disrupting and asthma-associated chemicals. Because use hair differs by race/ethnicity, these may contribute disease disparities. This preliminary study investigates the chemical content used U.S. Black women. We gas chromatography/mass spectrometry (GC/MS) test 18 in 6 categories women: hot oil treatment, anti-frizz/polish, leave-in conditioner, root stimulator, lotion, relaxer. tested for 66 chemicals belonging 10 classes:...

Per- and polyfluoroalkyl substances (PFASs) are used in a wide range of consumer products for their water- grease-resistant properties, but few studies have explored this exposure route. We multiple regression to investigate associations between six self-reported behaviors hypothesized influence PFAS serum concentrations chemicals 178 middle-aged women enrolled the Child Health Development Studies, about half whom African American. Blood samples were collected 2010-2013, participants...

In order to characterize typical indoor exposures chemicals of interest for research on breast cancer and other hormonally mediated health outcomes, methods were developed analyze air dust target compounds that have been identified as animal mammary carcinogens or active agents are used in commercial consumer products building materials. These applied a small number residential environments begin the extent exposure these classes compounds. Phenolic compounds, including nonylphenol,...

The recent flood of research concerning pollutants in personal environmental and biological samples-blood, urine, breastmilk, household dust air, umbilical cord blood, other media-raises questions about whether how to report results individual study participants. Clinical medicine provides an expert-driven framework, whereas community-based participatory emphasizes participants' right know the potential inform action even when health effects are uncertain. Activist efforts offer models. We...

We report on interviews conducted with participants in a novel study about environmental chemicals body fluids and household air dust. Interviews reveal how personal collective history influence the interpretation of exposure data, fashion an emergent understanding health problems from articulation science experience. To illness experience literature, we contribute framework for analyzing new category embodied narratives--"exposure experience"--that examines mediating role science. update...

Polychlorinated biphenyls (PCBs) are persistent pollutants identified worldwide as human blood and breast milk contaminants. Because they bioaccumulate, consumption of meat, fish, dairy products predicts concentrations. PCBs were also used widely in building materials, including caulks paints, but few studies have evaluated the contribution these exposures to body burden.In an earlier study, we detected indoor air 31% 120 homes on Cape Cod, MA. Two had much higher concentrations than rest,...