A5057385624- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Indoor Air Quality and Microbial Exposure
- Carcinogens and Genotoxicity Assessment
- Chemical Safety and Risk Management
- Hypothalamic control of reproductive hormones
- RNA Research and Splicing
- Air Quality Monitoring and Forecasting
- Steroid Chemistry and Biochemistry
- Health, Environment, Cognitive Aging
- Atmospheric chemistry and aerosols
- RNA and protein synthesis mechanisms
- Environmental Impact and Sustainability
- Ovarian function and disorders
- Estrogen and related hormone effects
- Occupational Health and Performance
- Environmental Justice and Health Disparities
- Per- and polyfluoroalkyl substances research
- TGF-β signaling in diseases
- Receptor Mechanisms and Signaling
- Noise Effects and Management
- Reproductive biology and impacts on aquatic species
- Dye analysis and toxicity
- Vehicle emissions and performance
Silent Spring Institute
2014-2024
New York City Fire Department
2019
Northeastern University
2019
Craft Engineering Associates (United States)
2010-2014
University of Virginia
2012
Columbia University
2010
Southwest Research Institute
2010
Harvard University
2006-2010
University of California, Davis
2006-2007
Massachusetts Department of Public Health
2007
The genome sequences of Chlamydia trachomatis mouse pneumonitis (MoPn) strain Nigg (1 069 412 nt) and pneumoniae AR39 229 853 were determined using a random shotgun strategy. MoPn exhibited general conservation gene order content with the previously sequenced C.trachomatis serovar D. Differences between strains focused on an ~50 kb 'plasticity zone' near termination origins. In this region contained three copies novel encoding >3000 amino acid toxin homologous to predicted from Escherichia...
Background: Bisphenol A (BPA) and bis(2-ethylhexyl) phthalate (DEHP) are high-production-volume chemicals used in plastics resins for food packaging. They have been associated with endocrine disruption animals some human studies. Human exposure sources estimated, but the relative contribution of dietary to total intake has not studied empirically.Objectives: To evaluate packaging exposure, we measured urinary BPA metabolites before, during, after a "fresh foods" intervention.Methods: We...
Higher house dust levels of PBDE flame retardants (FRs) have been reported in California than other parts the world, due to state's furniture flammability standard. However, changing these and FRs not evaluated following 2004 U.S. phase-out PentaBDE OctaBDE. We analyzed collected 16 homes 2006 again 2011 for 62 organohalogens, which represents broadest investigation homes. Fifty-five compounds were detected at least one sample; 41 50% samples. Concentrations chlorinated OPFRs, including two...
Background: Laboratory and human studies raise concerns about endocrine disruption asthma resulting from exposure to chemicals in consumer products. Limited labeling or testing information is available evaluate products as sources.Objectives: We analytically quantified disruptors asthma-related a range of cosmetics, personal care products, cleaners, sunscreens, vinyl also evaluated whether product labels provide that can be used select without these chemicals.Methods: selected 213 commercial...
Interest in the health effects of potential endocrine-disrupting compounds (EDCs) that are high production volume chemicals used consumer products has made exposure assessment and source identification a priority. We collected paired indoor outdoor air samples 40 nonsmoking homes urban, industrial Richmond, CA, 10 rural Bolinas, CA. Samples were analyzed by GC-MS for 104 analytes, including phthalates (11), alkylphenols (3), parabens polybrominated diphenyl ether (PBDE) flame retardants...
Phosphate flame retardants (PFRs) are abundant and found at the highest concentrations relative to other retardant chemicals in house dust; however, little is known about biological levels of PFRs their relationship with dust concentrations. These relationships provide insight into major exposure pathways potential health risks. We analyzed urine samples from 16 California residents 2011 for 6 chlorinated nonchlorinated dialkyl or diaryl phosphates (DAPs), expected metabolites most prominent...
Personal care products are a source of exposure to endocrine disrupting and asthma-associated chemicals. Because use hair differs by race/ethnicity, these may contribute disease disparities. This preliminary study investigates the chemical content used U.S. Black women. We gas chromatography/mass spectrometry (GC/MS) test 18 in 6 categories women: hot oil treatment, anti-frizz/polish, leave-in conditioner, root stimulator, lotion, relaxer. tested for 66 chemicals belonging 10 classes:...
Consumer products are important sources of exposure to harmful chemicals. Product composition is often a mystery users, however, due gaps in the laws governing ingredient disclosure. A unique data set that California Air Resources Board (CARB) uses determine how volatile organic chemicals (VOCs) from consumer affect smog formation holds partial solution. By analyzing CARB on VOCs products, we identified and quantified emissions regulated under Safe Drinking Water Toxic Enforcement Act ("Prop...
Residential exposure can dominate total for commercial chemicals of health concern; however, despite the importance consumer exposures, methods estimating household exposures remain limited. We collected house dust and indoor air samples in 49 California homes analyzed 76 semivolatile organic compounds (SVOCs)—phthalates, polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), pesticides. Sixty were detected either or here we report...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMICROBIOLOGICAL TRANSFORMATIONS. II. THE MICROBIOLOGICAL AROMATIZATION OF STEROIDSR Dodson and R MuirCite this: J. Am. Chem. Soc. 1958, 80, 18, 5004–5005Publication Date (Print):September 1, 1958Publication History Published online1 May 2002Published inissue 1 September 1958https://pubs.acs.org/doi/10.1021/ja01551a060https://doi.org/10.1021/ja01551a060research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations45LEARN...
Inhibin gene expression in the ovary is stimulated by FSH, which uses cAMP as an intracellular second messenger. To examine further transcriptional regulation of α inhibin FSH and cAMP, we have isolated characterized a genomic clone that contains entire rat gene. Sequence analysis promoter region revealed several potential response elements (CREs) transcription factor AP2-binding sites might mediate regulation. determine functional importance these sequences, fusion genes including 5′...
RNA-binding proteins containing KH domains are widely distributed. One domain protein of unknown function, vigilin (also known as the high density lipoprotein-binding protein), contains 14 and is ubiquitous in vertebrate cells. We previously used RNA gel mobility shift assays to describe an estrogen-inducible which binds specifically a segment 3′-untranslated region (3′-UTR) vitellogenin mRNA, area has been implicated estrogen-mediated stabilization mRNA. Here we show that mRNA-binding...
Administration of a potent gonadotropin-releasing hormone (GnRH) antagonist [Nac-L-Ala1,pCl-D-Phe2,D-Trp3,6]GnRH as single subcutaneous injection to castrated adult male rats reduced, by more than 90 percent, both serum luteinizing concentrations and specific pituitary GnRH receptor binding. This effect persisted for 24 hours. The dissociation rate the from membrane homogenates was fourfold slower agonist. prolonged in vivo inhibition binding secretion may be mediated its site.
Health disparities in low-income communities may be linked to residential exposures chemicals infiltrating from the outdoors and characteristics of sources home. Indoor comprise those introduced by occupant as well releases building materials. To examine impact renovation on indoor pollutants levels classify predominant sources, we collected air surface wipes newly renovated "green" housing units Boston before after occupancy. We targeted nearly 100 semivolatile organic compounds (SVOCs)...
The Life Cycle Initiative, hosted at the United Nations Environment Programme, selected human toxicity impacts from exposure to chemical substances as an impact category that requires global guidance overcome current assessment challenges. initiative leadership established Human Toxicity Task Force develop on assessing and impacts. Based input gathered three workshops addressing main scientific challenges questions, task force built a roadmap for advancing characterization, primarily use in...
Nearly all Americans have detectable concentrations of endocrine disrupting chemicals from consumer products in their bodies, and expert panels recommend reducing exposures. To inform exposure reduction, we investigated whether consumers who are trying to avoid certain lower exposures than those not. We also aimed make biomonitoring more widely available. enrolled 726 participants a crowdsourced study. targeted phenolic compounds—specifically parabens, bisphenol A (BPA) analogs F (BPF) S...
In Xenopus , estrogen induces the stabilization of vitellogenin mRNA and destabilization albumin mRNA. These processes correlate with increased polysomal activity a sequence-selective endonuclease, PMR-1, hnRNP K homology-domain RNA-binding protein, vigilin. Vigilin binds to region 3′-untranslated (3′-UTR) implicated in estrogen-mediated stabilization. The vigilin-binding site B1 3′-UTR contains two consensus PMR-1 cleavage sites. availability purified recombinant vigilin made it possible...
Abstract Background Children in urban public housing are at high risk for asthma, given elevated environmental and social exposures suboptimal medical care. For a multifactorial disease like design of intervention studies can be influenced by the relative prevalence key factors. To better understand factors asthma morbidity context an study, we conducted detailed baseline evaluation 78 children (aged 4–17 years) from three developments Boston. Methods Asthmatic their caregivers were...
The 3' untranslated region (3'-UTR) has been implicated in the estrogen stabilization of hepatic Xenopus laevis vitellogenin mRNA. We used RNA gel mobility shift assays to demonstrate that liver contains a factor which binds with very high specificity segment 3'-UTR B1 and B2 mRNAs. detected single high-affinity binding site mRNA localized 27-nucleotide region. Since was abolished by proteinase K digestion, at least component is protein. Following administration, induced approximately four-...
In the rat, central part of medial preoptic nucleus (MPNc) male is larger in volume and has a greater number neurons than that female. The female, however, can be "sex reversed" by exposing rat to gonadal steroids perinatally. purpose present study was examine development MPNc determine when sex difference first appears whether this occurs due relative accumulation into compact sex-reversed female or loss control Pregnant, Sprague-Dawley rats were given an injection [3H]methyl thymidine on...