A5023341440- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Health, Environment, Cognitive Aging
- Indoor Air Quality and Microbial Exposure
- Carcinogens and Genotoxicity Assessment
- Receptor Mechanisms and Signaling
- Occupational and environmental lung diseases
- Chemistry and Chemical Engineering
- Nicotinic Acetylcholine Receptors Study
- Climate Change Communication and Perception
- Pharmacological Receptor Mechanisms and Effects
- Animal testing and alternatives
- Ethics in Clinical Research
Silent Spring Institute
2017-2020
Columbia University
2005
Health disparities in low-income communities may be linked to residential exposures chemicals infiltrating from the outdoors and characteristics of sources home. Indoor comprise those introduced by occupant as well releases building materials. To examine impact renovation on indoor pollutants levels classify predominant sources, we collected air surface wipes newly renovated "green" housing units Boston before after occupancy. We targeted nearly 100 semivolatile organic compounds (SVOCs)...
Nearly all Americans have detectable concentrations of endocrine disrupting chemicals from consumer products in their bodies, and expert panels recommend reducing exposures. To inform exposure reduction, we investigated whether consumers who are trying to avoid certain lower exposures than those not. We also aimed make biomonitoring more widely available. enrolled 726 participants a crowdsourced study. targeted phenolic compounds—specifically parabens, bisphenol A (BPA) analogs F (BPF) S...
In Brief Several anesthetic drugs are nicotinic antagonists at or below levels used for anesthesia, including ketamine and volatile anesthetics. contrast, propofol does not inhibit receptors. To determine the potential behavioral ramifications of inhibition by ketamine, we determined doses required to induce immobility, impair righting reflex, cause analgesia in absence presence several ligands. Propofol was as a control similar experiments. When sole drug, 383 ± 22 mg/kg intraperitoneally...
Little is known about the willingness of prospective study participants to share environmental health data. To fill this gap, we conducted a hypothetical vignette survey among 1,575 women who have volunteered be contacted breast cancer studies. Eighty-three percent were interested in participating studies, with little difference whether data restricted research team, shared approved researchers, or publicly accessible. However, somewhat preferred controlled access for children’s Respondents...
Environmental health and exposure researchers can improve the quality interpretation of their chemical measurement data, avoid spurious results, analytical protocols for new chemicals by closely examining lab field control (QC) data. Reporting QC data along with measurements in biological environmental samples allows readers to evaluate appropriate uses (e.g., comparison other studies, association outcomes, use regulatory decision-making). However many studies do not adequately describe or...
Abstract Common environmental chemicals have plausible links to breast cancer because they are mammary gland carcinogens in animal studies or known activate relevant hormonal pathways enhance susceptibility of the carcinogenesis. An institute Medicine report prioritized human these exposures. Yet long latency and multifactorial etiology make evaluation humans challenging, adding importance study designs that well-suited capture hypothesized breast-cancer mechanisms. With this mind, we...